RKI-1447

Name: RKI-1447
SKU: A13067

目录号: A13067

ROCK1/ROCK2 抑制剂

RKI-1447 Chemical Structure

CAS NO. 1342278-01-6

RKI-1447是Rho相关ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。

库存：现货

规格	价格	数量
5 mg	￥ 540.00
10 mg	￥ 920.00
25 mg	￥ 2,400.00
50 mg	￥ 4,000.00
10mM * 1mL in DMSO	￥ 1,110.00

或

添加到收藏

产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

RKI-1447是Rho相关ROCK激酶的有效抑制剂，在乳腺癌中具有抗侵袭和抗肿瘤活性。

靶点信息

ROCK2	ROCK1
6.2 nM	14.5 nM

溶解度 *

In vitro (25°C)	DMSO	62 mg/mL (189.97 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	15% Captisol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.64 mL	153.2 mL	306.4 mL
0.5 mM	6.13 mL	30.64 mL	61.28 mL
1 mM	3.06 mL	15.32 mL	30.64 mL
5 mM	0.61 mL	3.06 mL	6.13 mL

*The above data is based on the productmolecular weight 326.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13067
作用机制	Inhibitor (抑制剂)
M. Wt	326.37
Formula	C16H14N4O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1342278-01-6
Synonyms	RKI1447; RKI 1447. ROCK Inhibitor XIII
SMILES	C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3