RO4929097

Name: RO4929097
SKU: A10802

目录号: A10802

Gamma-secretase 抑制剂

Product Citations (1)

RO4929097 Chemical Structure

CAS NO. 847925-91-1

RO4929097是一种γ secretase抑制剂，无细胞试验中IC50为4 nM。抑制Aβ40和Notch的细胞加工，EC50分别为14 nM和5 nM。

库存：现货

规格	价格	数量
5 mg	￥ 1,000.00
10 mg	￥ 1,800.00
50 mg	￥ 5,600.00
200 mg	￥ 13,800.00
10mM * 1mL in DMSO	￥ 1,530.00

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生物活性

RO4929097是一种γ secretase抑制剂，无细胞试验中IC50为4 nM。抑制Aβ40和Notch的细胞加工，EC50分别为14 nM和5 nM。

靶点信息

γ secretase (Cell-free assay)	γ secretase(ICN) (Cell-free assay)	Aβ40 (Cell-free assay)
4 nM	5 nM	14 nM

溶解度 *

In vitro (25°C)	DMSO	92 mg/mL (195.99 mM)
	Water	Insoluble
	Ethanol	16 mg/mL
In vivo	2% DMSO+30% PEG 300+5% Tween+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.3 mL	106.52 mL	213.04 mL
0.5 mM	4.26 mL	21.3 mL	42.61 mL
1 mM	2.13 mL	10.65 mL	21.3 mL
5 mM	0.43 mL	2.13 mL	4.26 mL

*The above data is based on the productmolecular weight 469.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10802
作用机制	Inhibitor (抑制剂)
M. Wt	469.4
Formula	C22H20F5N3O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	847925-91-1
SMILES	CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O