RO5126766 (CH5126766)

目录号: A14019

Raf/MEK dual 抑制剂

RO5126766 (CH5126766)

RO5126766 (CH5126766) Chemical Structure

CAS NO. 946128-88-7

RO5126766 (CH5126766)是对Raf和MEK丝裂原激活的蛋白激酶(MAPK)具有特异性的蛋白激酶抑制剂,具有潜在的抗肿瘤活性。

库存: 现货

规格 价格 数量
5 mg
¥ 1,400.00
10 mg
¥ 2,200.00
25 mg
¥ 4,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

RO5126766 (CH5126766)是对Raf和MEK丝裂原激活的蛋白激酶(MAPK)具有特异性的蛋白激酶抑制剂,具有潜在的抗肿瘤活性。
靶点信息
BRAF V600E BRAF CRAF MEK1
8.2 nM19 nM56 nM160 nM
In vitro (25°C) DMSO 93 mg/mL (197.26 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+ddH2O 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.21 mL 106.04 mL 212.09 mL
0.5 mM 4.24 mL 21.21 mL 42.42 mL
1 mM 2.12 mL 10.6 mL 21.21 mL
5 mM 0.42 mL 2.12 mL 4.24 mL

*The above data is based on the productmolecular weight 471.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14019
作用机制 Inhibitor (抑制剂)
M. Wt 471.5
Formula C21H18FN5O5S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 946128-88-7
Synonyms RO 5126766, RO-5126766, CH5126766, CH-5126766, CH 5126766.
SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F

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