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SB265610是CXCR2 (Kd = 2.51 nM)的非肽变构反向激动剂，通过与不同于激动剂结合位点的区域结合来防止受体活化。它不与相关CXCR1受体结合。在体外和高氧诱导肺损伤的大鼠模型中，它已被证明能防止中性粒细胞趋化性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28 mL | 139.99 mL | 279.99 mL |
| 0.5 mM | 5.6 mL | 28 mL | 56 mL |
| 1 mM | 2.8 mL | 14 mL | 28 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.6 mL |
*The above data is based on the productmolecular weight 357.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14195 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 357.16 |
| Formula | C14H9BrN6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 211096-49-0 |
| Synonyms | SB 265610,SB-265610 |
| SMILES | C1=CC=C(C(=C1)NC(=O)NC2=CC=C(C3=NNN=C23)C#N)Br |
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