产品详情
SB590885是B-Raf激酶的选择性小分子抑制剂,B-Raf和c-Raf的Ki app值分别为0.16和1.72 nM。
靶点信息
B-Raf (Cell-free assay) | ||||
0.16 nM(Ki) |
In vitro (25°C) | DMSO | 5 mg/mL (11.02 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.05 mL | 110.25 mL | 220.51 mL |
0.5 mM | 4.41 mL | 22.05 mL | 44.1 mL |
1 mM | 2.21 mL | 11.03 mL | 22.05 mL |
5 mM | 0.44 mL | 2.21 mL | 4.41 mL |
*The above data is based on the productmolecular weight 453.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A10829 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 453.5 |
Formula | C27H27N5O2 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 405554-55-4 |
Synonyms | SB-590885 |
SMILES | CN(C)CCOC1=CC=C(C=C1)C2=N/C(=C\3/C=CC4=C(CCC4=C3)N=O)/C(=C5C=CNC=C5)N2 |
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