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Sivelestat sodium salt是一种选择性白细胞弹性蛋白酶抑制剂（IC50 = 44 nM），在一系列其他蛋白酶中均无活性。它在体外抑制NF-κB活化和LTB4诱导的中性粒细胞转运。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.91 mL | 109.54 mL | 219.09 mL |
| 0.5 mM | 4.38 mL | 21.91 mL | 43.82 mL |
| 1 mM | 2.19 mL | 10.95 mL | 21.91 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
*The above data is based on the productmolecular weight 456.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14073 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 456.44 |
| Formula | C20H21N2NaO7S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 150374-95-1 |
| Synonyms | ONO-5046 |
| SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+] |
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