产品详情
SL-327是MEK1和MEK2的选择性抑制剂(IC50值分别为0.18和0.22μM);在体外阻断海马LTP。全身性给药后,体内的脑渗透剂会阻止大鼠的恐惧条件和学习,并在小鼠中产生神经保护作用。
Targets
Target | Value |
---|---|
MEK1 | IC50: 0.18μM |
MEK2 | IC50: 0.22μM |
AP-1 | IC50: 2.03μM |
PKC | IC50: >10μM |
MKK3/p38MAPK | IC50: 21μM |
ERK1 | IC50: >50μM |
MKK4 | IC50: >100μM |
JNK | IC50: >100μM |
In vitro (25°C) | DMSO | 66 mg/mL (196.81 mM) | |
Water | Insoluble | ||
Ethanol | 7 mg/mL (20.87 mM) | ||
In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 29.82 mL | 149.08 mL | 298.15 mL |
0.5 mM | 5.96 mL | 29.82 mL | 59.63 mL |
1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
5 mM | 0.6 mL | 2.98 mL | 5.96 mL |
*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A14137 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 335.4 |
Formula | C16H12F3N3S |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 305350-87-2 |
Synonyms | SL 327, SL327 |
SMILES | C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
AZD6244 (Selumetinib)
Selumetinib (AZD6244)是一种有效,高选择性的MEK抑制剂,ARRY142886,AZD-6244和ARRY-142886是MEK 1/2抑制剂,GI50值在14…
GDC-0973 (Cobimetinib)
GDC-0973 (Cobimetinib,RG7420)是一种有效且高度选择性的MEK1抑制剂,IC50为4.2 nM,对MEK1的选择性选择性是对MEK2的10…
Keywords:购买 SL-327 | SL-327 供应商 | 订购 SL-327 | SL-327 价格 | SL-327 生产商 | 订单 SL-327 | SL-327 代理商 | 购买 305350-87-2| 305350-87-2 供应商 | 订购 305350-87-2 | 305350-87-2 价格 | 305350-87-2 生产商 | 订单 305350-87-2 | 305350-87-2 代理商|buy SL-327 | SL-327 Supplier | purchase SL-327 | SL-327 cost | SL-327 manufacturer | order SL-327 | SL-327 distributor | buy 305350-87-2| 305350-87-2 Supplier | purchase 305350-87-2 | 305350-87-2 cost | 305350-87-2 manufacturer | order 305350-87-2 | 305350-87-2 distributor