SL-327

目录号: A14137

MKK/MEK 抑制剂

SL-327

SL-327 Chemical Structure

CAS NO. 305350-87-2

SL-327是MEK1和MEK2的选择性抑制剂(IC50值分别为0.18和0.22μM);在体外阻断海马LTP。全身性给药后,体内的脑渗透剂会阻止大鼠的恐惧条件和学习,并在小鼠中产生神经保护作用。

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
25 mg
¥ 800.00
50 mg
¥ 2,400.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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SL-327是MEK1和MEK2的选择性抑制剂(IC50值分别为0.18和0.22μM);在体外阻断海马LTP。全身性给药后,体内的脑渗透剂会阻止大鼠的恐惧条件和学习,并在小鼠中产生神经保护作用。
Targets
Target Value
MEK1IC50: 0.18μM
MEK2IC50: 0.22μM
AP-1IC50: 2.03μM
PKCIC50: >10μM
MKK3/p38MAPKIC50: 21μM
ERK1IC50: >50μM
MKK4IC50: >100μM
JNKIC50: >100μM
In vitro (25°C) DMSO 66 mg/mL (196.81 mM)
Water Insoluble
Ethanol 7 mg/mL (20.87 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.82 mL 149.08 mL 298.15 mL
0.5 mM 5.96 mL 29.82 mL 59.63 mL
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL

*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A14137
作用机制 Inhibitor (抑制剂)
M. Wt 335.4
Formula C16H12F3N3S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 305350-87-2
Synonyms SL 327, SL327
SMILES C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

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