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SNS-314

Aurora 抑制剂

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产品目录号: A10851

库存状态:中国现货中国现货

产品名 目录号 价格 数量
SNS-314 5mg A10851-5
¥ 700.00
SNS-314 10mg A10851-10
¥ 1,200.00
SNS-314 50mg A10851-50
¥ 3,800.00
SNS-314 100mg A10851-100
¥ 6,800.00
SNS-314 10mM * 1mL in DMSO A10851-10mM-D
¥ 1,330.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.

SNS-314

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Chemical Information

目录号 A10851
Mechanism of action Inhibitor
分子量 527.0
化学分子式 C18H15ClN6OS2.CH4O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1146618-41-8
Synonyms SNS314
SMILES code CS(=O)(=O)O.C1=CC(=CC(=C1)Cl)NC(=O)NC2=NC=C(S2)CCNC3=NC=NC4=C3SC=C4
化学名称 N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea

Biological Activity

Description
SNS-314 Mesylate is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
Targets
Aurora C Aurora A Aurora B
3 nM9 nM31 nM

Solubility

Solubility (25°C) * In vitro DMSO 105 mg/mL (199.22 mM)
Water 6 mg/mL (11.38 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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