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STA-21是一种有前途的STAT-3抑制剂，可在类风湿关节炎的实验模型中相互调节Th17和Treg细胞，抑制小鼠和人类的破骨细胞生成并减轻自身免疫炎症。
靶点信息
| STAT3 | ||||
| In vitro | DMSO | 21 mg/mL (68.55 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (6.52 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.65 mL | 163.23 mL | 326.47 mL |
| 0.5 mM | 6.53 mL | 32.65 mL | 65.29 mL |
| 1 mM | 3.26 mL | 16.32 mL | 32.65 mL |
| 5 mM | 0.65 mL | 3.26 mL | 6.53 mL |
*The above data is based on the productmolecular weight 306.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15885 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 306.31 |
| Formula | C19H14O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 111540-00-2 |
| Synonyms | Ochromycinone |
| SMILES | O=C1CC(C)CC2=CC=C3C(C(C4=CC=CC(O)=C4C3=O)=O)=C12 |
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