TAK-715

TAK-715 Chemical Structure

CAS NO. 303162-79-0

TAK 715是p38 MAPK抑制剂(p38MAPKα的IC50 = 7.1 nM),Wnt /β-catenin信号传导抑制剂,并抑制22种激酶(包括CK1δ/ε)超过80%。

库存: 现货

规格 价格 数量
10 mg
¥ 1,100.00
25 mg
¥ 2,200.00
50 mg
¥ 3,200.00
100 mg
¥ 5,500.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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TAK 715是p38 MAPK抑制剂(p38MAPKα的IC50 = 7.1 nM),Wnt /β-catenin信号传导抑制剂,并抑制22种激酶(包括CK1δ/ε)超过80%。
Targets
Target Value
p38αIC50: 7.1nM
p38βIC50: 0.20μM
p38γIC50: >10μM
p38δIC50: >10μM
JNK1IC50: >10μM
ERK1IC50: >10μM
IKKβIC50: >10μM
MEKK1IC50: >10μM
TAK1IC50: >10μM
In vitro (25°C) DMSO 72 mg/mL (180.22 mM)
Water Insoluble
Ethanol 14 mg/mL (35.04 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.03 mL 125.15 mL 250.31 mL
0.5 mM 5.01 mL 25.03 mL 50.06 mL
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL

*The above data is based on the productmolecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11582
作用机制 Inhibitor (抑制剂)
M. Wt 399.51
Formula C24H21N3OS
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 303162-79-0
Synonyms TAK715, TAK 715
SMILES CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C

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