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Tenovin-1是p53转录活性的小分子激活剂，可防止MDM2介导的p53降解。
靶点信息
| p53 | Mdm2 | |||
| In vitro (25°C) | DMSO | 65 mg/mL (175.92 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 15% Captisol | 14 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.06 mL | 135.32 mL | 270.64 mL |
| 0.5 mM | 5.41 mL | 27.06 mL | 54.13 mL |
| 1 mM | 2.71 mL | 13.53 mL | 27.06 mL |
| 5 mM | 0.54 mL | 2.71 mL | 5.41 mL |
*The above data is based on the productmolecular weight 369.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11943 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 369.5 |
| Formula | C20H23N3O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 380315-80-0 |
| SMILES | CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C |
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