Membrane Transporters/Ion Channels

产品 151 到 200 共 317个

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  1. NS-1643

    Catalog No. A15929
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    hERG channel activator
    NS-1643是一种人类以太相关基因(hERG)KV11.1通道激活剂(EC50 = 10.5 uM)。 了解更多
  2. NS1619

    Catalog No. A15975
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    Potassium channel activator
    NS1619是Bkca开启剂或大电导Ca2+激活的钾(BKCa,KCa1.1)通道激活剂。 了解更多
  3. Doxapram

    Catalog No. A15961
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    Doxapram能抑制TASK-1,TASK-3,TASK-1/TASK-3异二聚体通道功能,EC50分别为410 nM,37μM,9μM。Doxapram是一种呼吸刺激剂。静脉注射多沙普兰可刺激潮气量和呼吸频率的增加。 了解更多
  4. K+ Channel inhibitor

    Catalog No. A16182
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    K+ Channel 抑制剂
    K+ Channel inhibitor,Kv1.5(IKur)的二氢吡唑并嘧啶抑制剂的合成基础。 了解更多
  5. Cesium chloride

    Catalog No. A15341
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    Potassium channel blocker
    Cesium chloride是钾通道阻滞剂。抑制起搏器电流(If)和超极化激活的阳离子电流(Ih)。通过灭活GSK-3β来防止血清和钾缺乏的小脑颗粒神经元中caspase-3的激活和神经元凋亡。 了解更多
    • 最新产品

    SKA-31

    Catalog No. A17117
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    potassium channel activator
    SKA-31是KCa2和KCa3.1钙激活钾通道的激活剂。 了解更多
  6. 4-Aminopyridine

    Catalog No. A17490
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    Potassium channel blocker
    Dalfampridine is a potassium channel blocker used to help multiple sclerosis patients walk. 了解更多
  7. AUT1

    Catalog No. A18648
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    Kv3 potassium channel modulator
    AUT1 is a Kv3 potassium channel modulator with pEC50s of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC50, 4.5). 了解更多
  8. ML418

    Catalog No. A18426
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    Kir7.1 potassium channels blocker
    ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. 了解更多
  9. Y-26763

    Catalog No. A12271
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    K+ (KATP) channel activator
    Y-26763 is a K+ channel opener and active metabolite of Y-27152. Y-26763 is an ATP-sensitive K+ (KATP) channel activator. 了解更多
  10. JNJ 303

    Catalog No. A20952
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    IKs blocker
    JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. 了解更多
  11. RPR-260243

    Catalog No. A20977
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    HERG activator
    RPR-260243 is a novel activator of HERG; modifies HERG currents inhibited by dofetilide (IC50 = 58 nM); little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. 了解更多
  12. MK-7145

    Catalog No. A21030
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    ROMK inhibitor
    MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM. 了解更多
  13. Ivermectin

    Catalog No. A10490
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    Ivermectin是一种广谱抗寄生虫阿维菌素药物。 了解更多
  14. Talniflumate

    Catalog No. A13339
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    CaCC blocker
    Talniflumate是一种钙激活的氯离子通道(CaCC)(hCLCA1/mCLCA3)阻滞剂;在细胞培养和动物模型中减少粘蛋白的合成和释放。 了解更多
  15. CaCCinh-A01

    Catalog No. A15469
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    CaCCs 抑制剂
    CaCCinh-A01抑制人支气管和肠道细胞中的CaCC电流。还抑制TMEM16A通道(表达TMEM16A的FRT细胞中IC50 = 2.1 uM)。 了解更多
  16. T16Ainh-A01

    Catalog No. A15470
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    TMEM16A 抑制剂
    T16Ainh-A01是一种选择性TMEM16A钙激活的氯离子通道抑制剂,可强烈抑制唾液腺细胞中的氯离子电流。 了解更多
  17. Eact

    Catalog No. A16179
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    CaCC activator
    Eact激活钙激活的氯离子通道(CaCC)TMEM16A CaCC。 了解更多
  18. NPPB

    Catalog No. A16981
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    chloride channel blocker
    NPPB是一种氯离子通道阻滞剂(IC50 = 80 nM),也被确定为GPR35激动剂。 了解更多
  19. Dapagliflozin (BMS512148)

    Catalog No. A10285
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    SGLT2 抑制剂
    Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白(SGLT2)的亚型2,后者负责肾脏中至少90%的葡萄糖重吸收。 了解更多
  20. Canagliflozin

    Catalog No. A11100
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    SGLT2 抑制剂
    canagliflozin是2型亚钠葡萄糖转运蛋白(SGLT2)的抑制剂,作用于hSGLT2,无细胞试验中IC50为2.2 nM,比作用于hSGLT1选择性高413倍。 了解更多
  21. EGT1442

    Catalog No. A10155
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    SGLT2 抑制剂
    EGT1442是有效的选择性SGLT2抑制剂。 了解更多
  22. Empagliflozin

    Catalog No. A12440
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    Empagliflozin是一种有效的选择性葡萄糖钠共转运蛋白-2抑制剂,目前正在开发中,用于治疗2型糖尿病。 了解更多
  23. LX-4211

    Catalog No. A12680
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    SGLT 抑制剂?
    LX4211是双重SGLT1/SGLT2抑制剂。 了解更多
  24. Tofogliflozin

    Catalog No. A12690
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    SGLT2 抑制剂
    Tofogliflozin是亚型2钠葡萄糖转运蛋白(SGLT2)的抑制剂,可引起肾脏中至少90%的葡萄糖重吸收。 了解更多
  25. Remogliflozin

    Catalog No. A13971
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    SGLT2 抑制剂
    Remogliflozin抑制钠葡萄糖转运蛋白(SGLT2),后者负责肾脏中的葡萄糖重吸收。 了解更多
  26. Ipragliflozin

    Catalog No. A13556
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    SGLT2 抑制剂
    Ipragliflozin是一种高效的选择性SGLT2抑制剂,IC50为2.8 nM。SGLT1/3/4/5/6的效力很小且没有效力。 了解更多
  27. Luseogliflozin

    Catalog No. A13476
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    SGLT2 抑制剂
    Luseogliflozin是由Taisho Pharmaceutical开发的一种口服活性第二代钠葡萄糖共转运蛋白2(SGLT2)抑制剂,用于治疗2型糖尿病(T2DM)患者。 了解更多
  28. T-1095

    Catalog No. A15463
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    Na+-glucose transporter 抑制剂
    T-1095是Na+-葡萄糖共转运蛋白(SGLTs)的有效和选择性抑制剂。 了解更多
  29. Canagliflozin hemihydrate

    Catalog No. A16817
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    SGLT2 抑制剂
    Canagliflozin hemihydrate是半水形式的卡格列嗪,是一种SGLT2抑制剂,在无细胞检测中hSGLT2的IC50为2.2 nM,其选择性比hSGLT1高413倍。 了解更多
  30. Ertugliflozin L-pyroglutamic acid

    Catalog No. A18054
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    SGLT inhibitor
    Ertugliflozin pidolate belongs to the class of potent and selective inhibitors of the sodium-dependent glucose cotransporters (SGLT), more specifically the type 2 which is responsible for about 90% of the glucose reabsorption from glomerulus. 了解更多
  31. SGL5213

    Catalog No. A18723
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    SGLT1 抑制剂
    SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. 了解更多
  32. Dapagliflozin impurity

    Catalog No. A19103
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    SGLT2 抑制剂
    Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor. 了解更多
  33. Licogliflozin

    Catalog No. A12828
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    SGLT1/SGLT2 抑制剂
    Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor. 了解更多
  34. BAY-8002

    Catalog No. A18611
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    MCT1 inhibitor
    BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity. 了解更多
  35. AR-C155858

    Catalog No. A11293
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    MCT1 and MCT2 抑制剂
    AR-C155858是单羧酸转运蛋白mct1和mct2的有效抑制剂,它们与涉及跨膜螺旋7-10的细胞内位点结合。 了解更多
  36. CHC

    Catalog No. A13372
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    MCT 抑制剂
    CHC是单羧酸转运(MCT)抑制剂。在神经胶质瘤中具有抗肿瘤和抗血管生成活性;降低U251细胞的糖酵解代谢,迁移和侵袭。 了解更多
  37. AZD-3965

    Catalog No. A14186
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    MCT1 抑制剂
    AZD-3965(AZD3965)是具有1.6 nM结合亲和力的单羧酸盐转运蛋白1(MCT1)的选择性抑制剂,是MCT2的6倍选择性,在10μM时不抑制MCT4。 了解更多
  38. AR-C117977

    Catalog No. A14360
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    MCT1 抑制剂
    AR-C117977是一种有效的MCT1抑制剂,可以降低体内和体外的免疫应答,维持长期移植物存活,并诱导操作耐受性。 了解更多
  39. 7ACC2

    Catalog No. A15785
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    MCT 抑制剂
    7ACC2是一种新型有效的MCT抑制剂,IC50为11 nM,可抑制[14C]-乳酸盐涌入。针对癌细胞中乳酸转运的新型抗肿瘤治疗。 了解更多
  40. 7ACC1

    Catalog No. A15810
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    MCT 抑制剂?
    7ACC1在富含乳酸的肿瘤微环境中选择性干扰乳酸通量;在表达MCT1和MCT4转运蛋白的肿瘤细胞中,乳酸抑制乳酸盐流入,但不流出。 了解更多
  41. UK 5099

    Catalog No. A13038
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    MCT 抑制剂
    UK 5099是质膜单羧酸盐转运蛋白(MCT)和线粒体丙酮酸载体(MPC)的有效抑制剂。抑制丙酮酸依赖性的氧气消耗,IC50为50 nM。 了解更多
  42. Tezampanel

    Catalog No. A15259
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    AMPA 拮抗剂
    Tezampanel是AMPA和离子型谷氨酸受体的海藻酸盐家族的拮抗剂,对海藻酸盐受体的GluR5亚型具有选择性。 了解更多
  43. YM90K hydrochloride

    Catalog No. A15495
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    AMPA 拮抗剂
    YM90K hydrochloride是一种选择性AMPA受体拮抗剂,在局部缺血后给药后,可延迟整体缺血模型中的神经元死亡和局部缺血模型中的脑梗塞。 了解更多
  44. Talampanel

    Catalog No. A15515
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    AMPA/kainate receptor 拮抗剂
    Talampanel是AMPA受体的非竞争性拮抗剂,具有抗癫痫活性。 了解更多
  45. CP 465022 hydrochloride

    Catalog No. A13321
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    AMPA 拮抗剂
    CP 465022 hydrochloride是一种选择性的非竞争性AMPA拮抗剂,在大鼠皮质神经元中的IC50为25 nM,显示出有效的抗惊厥活性。 了解更多
  46. JNJ-61432059

    Catalog No. A20209
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    AMPAR negative modulator
    JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. 了解更多
  47. SYM2206

    Catalog No. A20843
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    AMPA receptor antagonist
    SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist. 了解更多
  48. PF-4778574

    Catalog No. A21157
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    AMPA receptor positive allosteric modulator
    PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models. 了解更多
  49. Fanapanel

    Catalog No. A21200
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    AMPA/kainate antagonist
    Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. 了解更多

产品 151 到 200 共 317个

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