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TRV130 HCl (Oliceridine)

Catalog No. A15444
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u-opioid receptor 激动剂

TRV130 HCl (Oliceridine)是一种新型的μ-opioid 受体（MOR）G蛋白偏向配体。诱导强大的G蛋白信号传导（pEC50 = 8.1），效力和功效与吗啡相似，但β-arrestin募集和受体内在化作用要低得多。了解更多

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- Preeti Manandhar, .et al. Tapentadol shows lower intrinsic efficacy at μ receptor than morphine and oxycodone, Pharmacol Res Perspect, 2022, 10:e00921 PMID: 35084120
- Li He, .et al. Pharmacological and genetic manipulations at the ?-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice, Neuropsychopharmacology, 2021, 13 July PMID: 34257415