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UNC569是一种新颖的小分子MER抑制剂，在体内和体外均可有效对抗急性淋巴细胞白血病。UNC569是第一种小分子Mer抑制剂。UNC569通过ERK1/2和AKT抑制Mer激活和下游信号传导。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.22 mL | 126.1 mL | 252.21 mL |
| 0.5 mM | 5.04 mL | 25.22 mL | 50.44 mL |
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
*The above data is based on the productmolecular weight 396.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13805 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 396.5 |
| Formula | C22H29FN6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1350547-65-7 |
| Synonyms | UNC-569, UNC 569 |
| SMILES | CCCCNC1=NC=C2C(=NN(C2=N1)CC3CCC(CC3)N)C4=CC=C(C=C4)F |
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