VX-809 (Lumacaftor)

Name: VX-809 (Lumacaftor)
SKU: A10986

目录号: A10986

CFTR modulator

Product Citations (4)

VX-809 (Lumacaftor) Chemical Structure

CAS NO. 936727-05-8

VX-809 (Lumacaftor)是用于治疗囊性纤维化（CF）的第二种口服研究候选化合物，通过促进突变型CFTR(F508del-CFTR)的成熟，从而纠正囊性纤维症中常见的CFTR突变，在fisher大鼠甲状腺细胞中EC50为0.1 μM。

库存：现货

规格	价格	数量
5 mg	￥ 450.00
10 mg	￥ 650.00
50 mg	￥ 1,000.00
10mM * 1mL in DMSO	￥ 650.00

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产品详情

生物活性

靶点信息

F508del-CFTR (Fisher rat thyroid cells)
0.1 μM(EC50)

溶解度 *

In vitro (25°C)	DMSO	88 mg/mL (194.51 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (13.26 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.1 mL	110.52 mL	221.04 mL
0.5 mM	4.42 mL	22.1 mL	44.21 mL
1 mM	2.21 mL	11.05 mL	22.1 mL
5 mM	0.44 mL	2.21 mL	4.42 mL

*The above data is based on the productmolecular weight 452.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10986
作用机制	Modulator (调节剂)
M. Wt	452.4
Formula	C24H18F2N2O5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	936727-05-8
Synonyms	VX809
SMILES	CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O