XEN445

目录号: A13150

Endothelial lipase(EL) 抑制剂

XEN445

XEN445 Chemical Structure

CAS NO. 1515856-92-4

XEN445是内皮脂肪酶(EL)抑制剂,IC50为0.237 uM,具有很好的ADME和PK活性,能提高小鼠血浆中高密度脂蛋白胆固醇浓度。

库存: 现货

规格 价格 数量
2 mg
¥ 400.00
5 mg
¥ 700.00
10 mg
¥ 1,300.00
10mM * 1mL in DMSO
¥ 1,100.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

XEN445是内皮脂肪酶(EL)抑制剂,IC50为0.237 uM,具有很好的ADME和PK活性,能提高小鼠血浆中高密度脂蛋白胆固醇浓度。
靶点信息
Targets
endothelial lipase
0.237 μM
In vitro DMSO 79 mg/mL (215.65 mM)
Water Insoluble
Ethanol Warmed: 34 mg/mL (92.81 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.3 mL 136.49 mL 272.98 mL
0.5 mM 5.46 mL 27.3 mL 54.6 mL
1 mM 2.73 mL 13.65 mL 27.3 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

*The above data is based on the productmolecular weight 366.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13150
作用机制 Inhibitor (抑制剂)
M. Wt 366.33
Formula C18H17F3N2O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1515856-92-4
Synonyms XEN-445, XEN 445
SMILES C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O

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