FLT3

Catalog No.Inhibitor Name FLT3Other
A10996Cabozantinib
**
VEGFR2/KDR,c-Met,Kit
A10027Quizartinib
***
A11411Dovitinib
****
c-Kit,VEGFR3/FLT4,FGFR1
A10610Amuvatinib
*
c-Kit (D816H),PDGFRα (V561D)
A10887Tandutinib
*
c-Kit,PDGFRβ,CSF-1R
A11180TG101209
*
JAK2,RET,JAK3
A10508KW-2449
****
Abl (T315I),Abl,FGFR1
A10352ENMD-2076
***
RET,Aurora A,VEGFR3/FLT4
A10198Dovitinib Dilactic Acid
****
c-Kit,FGFR1,VEGFR3/FLT4
A12694Pacritinib
**
JAK2 (V617F),JAK2,TYK2
A12427TCS 359
*
A10352ENMD-2076 L-(*)-Tartaric acid
RET,Aurora A,VEGFR3/FLT4
A15904UNC2025
****
Mer
A14025AMG 925
****
CDK4,CDK1
A14214G-749
****
Mer,Aurora B,RET
A14156AZD2932
PDGFRβ,VEGFR-2,c-Kit
A10769R406
Syk
A12419Go6976
JAK2,PKCα,PKCβ1
A11962TG-02 (SB1317)
*
CDK2, JAK2
A14411Gilteritinib (ASP2215)
****
Axl
A15003AST 487
Ret, c-Kit, KDR, c-Abl
A15520Pexidartinib (PLX3397)
*
Kit, CSF-1R
A15548SU5614
A16248BPR1J-097
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

2 个项目

每页

设置升序顺序
  1. KW-2449

    Catalog No. A10508
    Quick View
    FLT3/FGFR/Bcr-Abl/Aurora 抑制剂
    KW-2449是FLT3、ABl、ABl-T315I和Aurora激酶的多激酶抑制剂。 了解更多
  2. ENMD-2076

    Catalog No. A10352
    Quick View
    Aurora A / FLT3 抑制剂
    ENMD-2076具有针对Aurora A和Flt3的选择性活性,IC50为14 nM和1.86 nM,对Aurora A的选择性是Aurora B的25倍,对VEGFR2/KDR和VEGFR3,FGFR1和FGFR2和PDGFRα的作用较小。阶段2。 了解更多

2 个项目

每页

设置升序顺序
Rewards