CXCR

Catalog No.Inhibitor Name CXCR1CXCR2CXCR4Other
A10913Plerixafor 8HCl
**
CXCL12-mediated chemotaxis
A13074Plerixafor
**
CXCL12-mediated chemotaxis
A12588WZ811
****
A14209SB225002
***
A16351ATI-2341
*
A14997AMD-070 HCl
***
A15234SCH 563705
****
***
A14209SB225002
***
A11555SCH-527123 (Navarixin)
**
***
A12383Reparixin
****
**
CXCL8
A12596MSX-122
***
A11315AMD 070
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Reparixin

    Catalog No. A12383
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    CXCL8/CXCR1/2 抑制剂
    Reparixin是两种CXCL8受体CXCR1/2的有效抑制剂,它抑制CXCR2介导的细胞迁移(IC50 = 100 nM),而它强烈地阻断CXCR1介导的趋化性(IC50 = 1 nM)。 了解更多
  2. MSX-122

    Catalog No. A12596
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    CXCR4 抑制剂
    MSX-122是口服可生物利用的CXCR4抑制剂(IC50 =?10 nM),具有潜在的抗肿瘤和抗病毒活性。CXCR4抑制剂MSX-122与趋化因子受体CXCR4结合,阻止基质衍生因子-1(SDF-1)与CXCR4受体和受体激活结合,这可能导致肿瘤细胞增殖和迁移减少。 了解更多
  3. Reparixin L-lysine salt

    Catalog No. A15219
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    CXCL8 receptor 抑制剂
    Reparixin L-lysine salt是CXCL8受体的抑制剂,也抑制CXCR1和CXCR2的活化,已显示在各种损伤模型中减弱了炎症反应。 了解更多

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