AZD8186

目录号: A15759

PI3K 抑制剂

AZD8186

AZD8186 Chemical Structure

CAS NO. 1627494-13-6

AZD8186是一种同工型特异性小分子PI3K抑制剂,有效抑制PI3Kβ(IC50 = 4 nM)和PI3Kδ(IC50 = 12 nM),选择性高于PI3Kα(IC50 = 35 nM)和PI3Kγ(IC50 = 675 nM)。

库存: 现货

规格 价格 数量
10 mg
¥ 1,100.00
25 mg
¥ 3,000.00
50 mg
¥ 3,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

AZD8186是一种同工型特异性小分子PI3K抑制剂,有效抑制PI3Kβ(IC50 = 4 nM)和PI3Kδ(IC50 = 12 nM),选择性高于PI3Kα(IC50 = 35 nM)和PI3Kγ(IC50 = 675 nM)。
Targets
Target Value
PI3KβIC50: 3nM
PI3KβIC50: 4nM
PI3KδIC50: 12nM
PI3KδIC50: 17nM
PI3KαIC50: 35nM
PI3KγIC50: 675nM
In vitro (25°C) DMSO Warmed: 82 mg/mL (179.25 mM)
Water Insoluble
Ethanol Warmed: 32 mg/mL (69.94 mM)
In vivo 10% DMSO + 60% TEG+ 30% WFI 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.86 mL 109.3 mL 218.59 mL
0.5 mM 4.37 mL 21.86 mL 43.72 mL
1 mM 2.19 mL 10.93 mL 21.86 mL
5 mM 0.44 mL 2.19 mL 4.37 mL

*The above data is based on the productmolecular weight 457.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A15759
作用机制 Inhibitor (抑制剂)
M. Wt 457.47
Formula C24H25F2N3O4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1627494-13-6
Synonyms AZD 8186, AZD-8186
SMILES CC(C1=C2C(=CC(=C1)C(=O)N(C)C)C(=O)C=C(O2)N3CCOCC3)NC4=CC(=CC(=C4)F)F

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