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BIBX1382

EGFR 抑制剂

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产品目录号: A15531

库存状态:中国现货中国现货

产品名 目录号 价格 数量
BIBX1382 5mg A15531-5
¥ 750.00
BIBX1382 10mg A15531-10
¥ 1,200.00
BIBX1382 25mg A15531-25
¥ 2,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

BIBX1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 _mu_M) and a range of other related tyrosine kinases (IC50 > 10 _mu_M),

BIBX1382

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Chemical Information

目录号 A15531
Mechanism of action Inhibitor
分子量 387.84
化学分子式 C18H19ClFN7
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 96612-93-8
Synonyms Falnidamol, BIBX-1382, BIBX 1382
SMILES code CN1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl
化学名称 4-N-(3-chloro-4-fluorophenyl)-6-N-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-4,6-diamine

生物活性

Description
BIBX1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 _mu_M) and a range of other related tyrosine kinases (IC50 > 10 _mu_M),

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.78 mL 128.92 mL 257.84mL
0.5 mM 5.16 mL 25.78 mL 51.57 mL
1 mM 2.58 mL 12.89 mL 25.78 mL
5 mM 0.52 mL 2.58 mL 5.16 mL

*The above data is based on the productmolecular weight 387.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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