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AMG-510 (Sotorasib)
Catalog No. A19021 KRAS G12C covalent inhibitorAMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. 了解更多 -
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Vaborbactam
Catalog No. A20638 β-lactamase inhibitorVaborbactam is a cyclic boronic acid pharmacophore β-lactamase inhibitor. 了解更多 -
BCR-ABL-IN-2
Catalog No. A21043 inhibitor of BCR-ABL1 tyrosine kinaseBCR-ABL-IN-2 is an inhibitor of BCR-ABL1 tyrosine kinase, with IC50s of 57 nM, 773 nm for ABL1native and ABL1T315I, respectively. 了解更多 -
Tirabrutinib
Catalog No. A21019 BTK inhibitorTirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM. 了解更多 -
Ilorasertib
Catalog No. A20982 ATP-competitive multitargeted kinase inhibitorIlorasertib (ABT-348) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. 了解更多 -
CK-666
Catalog No. A20973 Arp2/3 complex inhibitorCK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation. 了解更多 -
SEL120-34A HCl
Catalog No. A21485 CDK8 inhibitorSEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. 了解更多 -
Veliparib dihydrochloride
Catalog No. A21356 PARP inhibitorVeliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively. 了解更多 -
Carotegrast
Catalog No. A21997 α4 integrin receptor inhibitorCarotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities. 了解更多 -
Aliskiren D6 Hydrochloride
Catalog No. A21913 direct renin inhibitorAliskiren D6 Hydrochloride (CGP 60536 D6 Hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor with IC50 of 1.5 nM. 了解更多 -
L-Buthionine-(S,R)-sulfoximine
Catalog No. A21895 g-glutamylcysteine synthetase inhibitorL-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. 了解更多 -
TAK-659 hydrochloride
Catalog No. A21885 Syk inhibitorTAK-659 hydrochloride is a potent, selective and orally available spleen tyrosine kinase (Syk) inhibitor with an IC50 of 3.2 nM. 了解更多 -
Febuxostat D9
Catalog No. A21882 xanthine oxidase inhibitorFebuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM. 了解更多 -
Etoricoxib D4
Catalog No. A21877 COX-2 inhibitorEtoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. 了解更多 -
Vilazodone D8
Catalog No. A21876 SSR inhibitor / 5-HT1A receptor partial agonistVilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. 了解更多 -
Tesevatinib
Catalog No. A21875 multi-target tyrosine kinase inhibitorTesevatinib (XL-647; EXEL-7647; KD-019) is an orally available, multi-target tyrosine kinase inhibitor; inhibits EGFR, ErbB2, KDR, Flt4 and EphB4 kinase with IC50s of 0.3, 16, 1.5, 8.7, and 1.4 nM. 了解更多 -
Fostamatinib disodium hexahydrate
Catalog No. A21873 Syk inhibitorFostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. 了解更多 -
Btk inhibitor 1 R enantiomer hydrochloride
Catalog No. A21865 BTK inhibitorBtk inhibitor 1 R enantiomer hydrochloride (Ibrutinib analog hydrochloride) (Compound 14) is a covalent and irreversible Bruton??s tyrosine kinase (BTK) inhibitor and can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs). 了解更多 -
Btk inhibitor 1 (R enantiomer)
Catalog No. A21861 BTK inhibitorBtk inhibitor 1 R enantiomer (Ibrutinib analog) (Compound 14) is a covalent and irreversible Bruton??s tyrosine kinase (BTK) inhibitor and can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs). 了解更多 -
Cediranib maleate
Catalog No. A21857 VEGFR inhibitorCediranib maleate (AZD-2171 maleate) is a highly potent, orally available VEGFR inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively. 了解更多 -
AZD5153 6-Hydroxy-2-naphthoic acid
Catalog No. A21852 BET/BRD4 bromodomain inhibitorAZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM. 了解更多 -
Zileuton sodium
Catalog No. A21831 5-lipoxygenase inhibitorZileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities. 了解更多 -
CP-640186 hydrochloride
Catalog No. A21808 ACC inhibitorCP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. 了解更多 -
Lumicitabine
Catalog No. A21807 RSV polymerase inhibitorLumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase. 了解更多 -
1-Naphthyl PP1 hydrochloride
Catalog No. A21790 Src/c-Abl inhibitor1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). 了解更多 -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多 -
PSI-6206 13CD3
Catalog No. A21782 HCV NS5B polymerase inhibitorPSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. 了解更多 -
SHP099 hydrochloride
Catalog No. A21762 SHP2 inhibitorSHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM. 了解更多 -
Tazemetostat hydrobromide
Catalog No. A21759 EZH2 inhibitorTazemetostat hydrobromide (EPZ-6438 hydrobromide) is a potent, selective and orally available EZH2 inhibitor. 了解更多 -
BMS-654457
Catalog No. A21704 Factor XIa (FXIa) inhibitorBMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively. 了解更多 -
TAK-960 hydrochloride
Catalog No. A21703 PLK1 inhibitorTAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. 了解更多 -
BMS-599626
Catalog No. A21664 HER1/HER2 inhibitorBMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. 了解更多 -
HS-10296 hydrochloride
Catalog No. A21661 EGFR/T790M inhibitorHS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. 了解更多 -
AZD3839 free base
Catalog No. A21606 BACE1 inhibitorAZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多 -
Dutogliptin
Catalog No. A21573 DPP4 inhibitorDutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. 了解更多 -
GDC-0575 dihydrochloride
Catalog No. A21567 CHK1 inhibitorGDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. 了解更多
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