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产品 1 到 50 共 56个

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  1. NS-018 maleate
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    NS-018 maleate

    Catalog No. A16226
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    JAK2 抑制剂
    NS-018 maleate是在Ba/F3-JAK2V617F细胞中具有ATP竞争性的JAK2小分子抑制剂，IC50为470nM。与其他JAK家族激酶（例如JAK1，JAK3和酪氨酸激酶2）相比，对JAK2的选择性高30-50倍。 了解更多
  2. NS-018 hydrochloride
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    NS-018 hydrochloride

    Catalog No. A16225
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    JAK2 抑制剂
    NS-018 hydrochloride是一种新型的高选择性JAK2抑制剂。 了解更多
  3. NS-018
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    NS-018

    Catalog No. A16224
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    JAK2 抑制剂
    NS-018是Janus相关激酶2（JAK2）和Src家族激酶的口服生物利用型小分子抑制剂，具有潜在的抗肿瘤活性。 了解更多
  4. LY 345899
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    LY 345899

    Catalog No. A19440
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    MTHFD1/MTHFD2 inhibitor
    LY 345899 is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 0.018 μM. 了解更多
  5. HCV-IN-3
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    HCV-IN-3

    Catalog No. A20957
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    HCV NS3/4a protein inhibitor
    HCV-IN-3 is a hepatitis C virus (HCV) NS3/4a protein inhibitor, with an IC50 of 20 μM, a Kd of 29 μM. 了解更多
  6. CP-640186 hydrochloride
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    CP-640186 hydrochloride

    Catalog No. A21808
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    ACC inhibitor
    CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. 了解更多
  7. ML132
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    ML132

    Catalog No. A21557
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    caspase 1 inhibitor
    ML132 (NCGC 00185682) is a potent and selective caspase 1 inhibitor with an IC50 of 0.316 nM. 了解更多
  8. Encequidar mesylate
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    Encequidar mesylate

    Catalog No. A21556
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    P-glycoprotein inhibitor
    Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor. 了解更多
  9. CVT-12012
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    CVT-12012

    Catalog No. A21447
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    SCD inhibitor
    CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. 了解更多
  10. Encequidar
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    Encequidar

    Catalog No. A21212
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    P-glycoprotein inhibitor
    Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein. 了解更多
  11. MDR-1339
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    MDR-1339

    Catalog No. A21138
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    Aβ-aggregation inhibitor
    MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer's disease. 了解更多
  12. Relebactam
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    Relebactam

    Catalog No. A21071
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    diazabicyclooctane inhibitor
    Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. 了解更多
  13. IDO-IN-3
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    IDO-IN-3

    Catalog No. A20898
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    IDO inhibitor
    IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM. 了解更多
  14. Niraparib hydrochloride
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    Niraparib hydrochloride

    Catalog No. A18018
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    PARP1 and PARP2 inhibitor
    Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. 了解更多
  15. KRas G12C inhibitor 4
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    KRas G12C inhibitor 4

    Catalog No. A12972
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    KRas G12C inhibitor
    KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. 了解更多
  16. BRD-6929
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    BRD-6929

    Catalog No. A12511
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    HDAC1/HDAC2 inhibitor
    BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50=?1 and 8 nM), extracted from patent US2018360927. 了解更多
  17. Ruxolitinib sulfate
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    Ruxolitinib sulfate

    Catalog No. A11467
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    JAK1/2 inhibitor
    Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3. 了解更多
  18. KRas G12C inhibitor 3
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    KRas G12C inhibitor 3

    Catalog No. A13018
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    Kras-G12C inhibitor
    KRas G12C inhibitor 3 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. 了解更多
  19. KRas G12C inhibitor 2
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    KRas G12C inhibitor 2

    Catalog No. A13064
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    Kras-G12C inhibitor
    KRas G12C inhibitor 2 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. 了解更多
  20. KRas G12C inhibitor 1
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    KRas G12C inhibitor 1

    Catalog No. A13152
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    Kras-G12C inhibitor 1
    KRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. 了解更多
  21. EBI-1051
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    EBI-1051

    Catalog No. A13176
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    MEK inhibitor
    EBI-1051 is a highly potent and orally efficacious MEK inhibitor with an IC50 of 3.9 nM. 了解更多
  22. TPOP146
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    TPOP146

    Catalog No. A12655
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    CBP/P300 benzoxazepine bromodomain inhibitor
    TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. 了解更多
  23. RET-IN-1
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    RET-IN-1

    Catalog No. A19015
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    RET inhibitor
    RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively . 了解更多
  24. Fluopyram
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    Fluopyram

    Catalog No. A19018
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    SDH inhibitor
    Fluopyram is a succinate dehydrogenase inhibitor fungicide, inhibits the growth of F. virguliforme isolates with mean EC50 of 3.35 ?g/mL. 了解更多
  25. RIPK1-IN-3
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    RIPK1-IN-3

    Catalog No. A19023
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    RIPK1 inhibitor
    RIPK1-IN-3 (Example 38), a RIPK1 inhibitor, extracted from patent WO2018148626A1, possesses anti-inflammatory proprieties. 了解更多
  26. JAK1-IN-7
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    JAK1-IN-7

    Catalog No. A19029
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    JAK1 抑制剂
    JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect. 了解更多
  27. KRAS G12C inhibitor 13
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    KRAS G12C inhibitor 13

    Catalog No. A19041
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    KRAS G12C inhibitor
    KRAS G12C inhibitor 13 is a KRAS G12C inhibitor extracted from patent WO2018143315A1, compound 30. 了解更多
  28. HIV-1 inhibitor-3
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    HIV-1 inhibitor-3

    Catalog No. A19110
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    HIV infection inhibitor
    HIV-1 inhibitor-3 is a HIV infection inhibitor extracted from patent US2018360927. 了解更多
  29. TP0463518
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    TP0463518

    Catalog No. A20183
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    PHD inhibitor
    TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. 了解更多
  30. TPN171
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    TPN171

    Catalog No. A18464
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    PDE5 inhibitor
    TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. 了解更多
  31. FGTI-2734
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    FGTI-2734

    Catalog No. A18578
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    FT/GGT dual inhibitor
    FGTI-2734 is a RAS C-terminal mimetic dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitor with IC50s of 250 nM and 520 nM for FT and GGT, respectively. 了解更多
  32. GW284543
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    GW284543

    Catalog No. A18808
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    MEK5 inhibitor
    GW284543, also known as UNC10225170;, is a potent and selective MEK5 inhibitor with the potential for cancer treatment. 了解更多
  33. DO-264
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    DO-264

    Catalog No. A18881
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    ABHD12 inhibitor
    DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12 (ABHD12), with an IC50 of 11 nM. 了解更多
  34. Ruxolitinib Phosphate
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    Ruxolitinib Phosphate

    Catalog No. A11552
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    JAK 抑制剂
    Ruxolitinib Phosphate是ruxolitinib的磷酸盐形式，ruxolitinib是一种口服生物可利用的Janus相关激酶(JAK)抑制剂，具有潜在的抗肿瘤和免疫调节活性。 了解更多
  35. 4-Chloro-DL-phenylalanine
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    4-Chloro-DL-phenylalanine

    Catalog No. A16424
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    Tryptophan hydroxylase 抑制剂
    4-Chloro-DL-phenylalanine是色氨酸羟化酶的选择性和不可逆抑制剂，色氨酸羟化酶是5-羟色胺（5-羟色胺）生物合成中的限速酶。 了解更多
  36. Afuresertib
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    Afuresertib

    Catalog No. A16392
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    Akt 抑制剂
    Afuresertib是一种有效的口服生物利用性Akt抑制剂，对于Akt1，Akt2和Akt3，Ki分别为0.08 nM，2 nM和2.6 nM。 了解更多
  37. BI 224436
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    BI 224436

    Catalog No. A16018
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    HIV integrase 抑制剂
    BI 224436是一种新型的HIV-1非催化位点整合酶抑制剂。具有针对不同HIV-1实验室菌株的<15 nM的抗病毒EC50，细胞毒性> 90μM。 了解更多
  38. TCS 21311
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    TCS 21311

    Catalog No. A15365
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    JAK3 抑制剂
    TCS 21311是有效的JAK3抑制剂（IC50 = 8 nM）。TCS 21311对于JAK3相对于JAK1，JAK2和Tyk 2具有选择性（IC50值分别为1017、2550和8055 nM）。 了解更多
  39. TG 100801 HCl
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    TG 100801 HCl

    Catalog No. A15261
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    VEGFr2 抑制剂
    TG 100801 HCl是TG 100572（HY-10184）的前药，TG 100572是一种多靶点激酶抑制剂，可抑制选择性生长因子受体酪氨酸激酶和Src家族激酶，IC50值为2/7/2/1/0.5 nM或VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse分别。 了解更多
  40. Bay 65-1942 R form
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    Bay 65-1942 R form

    Catalog No. A15018
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    IKK 抑制剂?
    Bay 65-1942 R form是一种ATP竞争性抑制剂，可选择性靶向IKKβ激酶。 了解更多
  41. S-Ruxolitinib
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    S-Ruxolitinib

    Catalog No. A14955
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    JAK 抑制剂
    S-Ruxolitinib是INCB018424的手性化合物，是一种有效且选择性的小分子Janus激酶1（JAK1）和JAK2抑制剂。 了解更多
  42. Afuresertib HCl
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    Afuresertib HCl

    Catalog No. A13030
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    AKT 抑制剂?
    Afuresertib HCl，也称为GSK2110183，是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt（蛋白激酶B）的生物利用抑制剂。它结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关，PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。 了解更多
  43. D4476
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    D4476

    Catalog No. A13949
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    CK1 抑制剂
    D4476是酪蛋白激酶1的细胞渗透抑制剂。 了解更多
  44. CP-640186
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    CP-640186

    Catalog No. A13134
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    acetyl-CoA carboxylase 抑制剂
    CP-640186是一种同工酶非选择性乙酰辅酶a羧化酶(acc)抑制剂，其ic50s分别为53 nm和61nm；与cp-610431相比，代谢稳定性提高。 了解更多
  45. GF 109203X
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    GF 109203X

    Catalog No. A13197
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    PKC 抑制剂
    GF 109203X是一种有效且选择性的蛋白激酶C抑制剂，对α和β1亚型具有选择性（对于α，β1，δ，δ，ε和ζ亚型，IC50分别为0.0084、0.0180、0.210、0.132和5.8μM）。对MLCK，PKG和PKA具有选择性（IC50值分别为0.6、4.6和33μM）。5-HT3受体的强效拮抗剂（Ki = 29.5 nM）。= 29.5 nm)。 了解更多
  46. CGP 3466B maleate
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    CGP 3466B maleate

    Catalog No. A12385
    GAPDH 抑制剂
    CGP 3466B maleate是口服活性甘油醛-3-磷酸脱氢酶(gapdh)抑制剂。 了解更多
  47. JZL184
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    JZL184

    Catalog No. A12747
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    MAGL 抑制剂
    JZL184是一种有效的选择性单酰基甘油脂肪酶（MAGL）抑制剂。体内阻断内源性大麻素2-花生四烯酸甘油酯（2-AG）的水解（IC50 = 8 nM）。 了解更多
  48. LX-4211
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    LX-4211

    Catalog No. A12680
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    SGLT 抑制剂?
    LX4211是双重SGLT1/SGLT2抑制剂。 了解更多
  49. Carbidopa
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    Carbidopa

    Catalog No. A10181
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    aromatic-L-amino-acid decarboxylase 抑制剂
    Carbidopa是一种芳香族-L-氨基酸脱羧酶抑制剂，这是一种在L-色氨酸生物合成5-羟色胺和L-DOPA生物合成多巴胺（DA）中重要的酶。 了解更多
  50. CCT129202
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    CCT129202

    Catalog No. A10184
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    Aurora 抑制剂
    CCT129202是一种ATP竞争性的pan-Aurora抑制剂，作用于Aurora A，Aurora B和Aurora C时，IC50分别为0.042 μM，0.198 μM和0.227 μM，对FGFR3， GSK3β， PDGFRβ等作用效果稍弱。 了解更多

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  1. Epigenetics (13)
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