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“jwh 073”的搜索结果

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  1. Pocapavir (SCH-48973)
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    Pocapavir (SCH-48973)

    Catalog No. A18331
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    EV capsid inhibitor
    Pocapavir is an investigational enterovirus (EV) capsid inhibitor. 了解更多
  2. Defactinib hydrochloride
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    Defactinib hydrochloride

    Catalog No. A22003
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    FAK inhibitor
    Defactinib hydrochloride (VS-6063 hydrochloride; PF 04554878 hydrochloride) is a novel FAK inhibitor, which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner. 了解更多
  3. Defactinib
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    Defactinib

    Catalog No. A21958
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    FAK inhibitor
    Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities. 了解更多
  4. Gosogliptin
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    Gosogliptin

    Catalog No. A21566
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    DPP-IV inhibitor
    Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV). 了解更多
  5. B-Raf IN 1
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    B-Raf IN 1

    Catalog No. A21055
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    B-Raf kinase inhibitor
    B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. 了解更多
  6. Loxapine
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    Loxapine

    Catalog No. A18073
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    D2DR/D4DR inhibitor
    Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. 了解更多
  7. Cabozantinib S-malate
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    Cabozantinib S-malate

    Catalog No. A11349
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    multiple receptor tyrosine kinases inhibitor
    Cabozantinib S-malate (XL184 S-malate) is a potent multiple receptor tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50s of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. 了解更多
  8. RPR107393 free base
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    RPR107393 free base

    Catalog No. A13051
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    squalene synthase inhibitor
    RPR107393 free base is a selective squalene synthase inhibitor, which inhibits rat liver microsomal squalene synthase with an IC50 of 0.8??0.2 nM. 了解更多
  9. PSI-7409
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    PSI-7409

    Catalog No. A13962
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    nucleotide analog HCV inhibitor
    PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. 了解更多
  10. TD-0212
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    TD-0212

    Catalog No. A13715
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    neprilysin (NEP) inhibitor
    TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP. 了解更多
  11. GSK547
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    GSK547

    Catalog No. A19073
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    RIP1 inhibitor
    GSK547 (GSK-547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. 了解更多
  12. BN82002
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    BN82002

    Catalog No. A19386
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    CDC25 phosphatase family inhibitor
    BN82002 is a potent, selective and irreversible inhibitor of CDC25 phosphatase family. 了解更多
  13. LY223982
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    LY223982

    Catalog No. A19436
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    LTB4 receptor inhibitor
    LY223982 is a potent and specific inhibitor of leukotriene B4 receptor, with an IC50 of 13.2 nM against [3H]LTB4 binding to LTB4 receptor. 了解更多
  14. SBC-110736
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    SBC-110736

    Catalog No. A20151
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    PCSK9 inhibitor
    SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1, Figure 1. 了解更多
  15. ZT-12-037-01
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    ZT-12-037-01

    Catalog No. A18395
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    ATP-competitive STK19 inhibitor
    ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor. ZT-12-037-01 effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. 了解更多
  16. MI-1061
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    MI-1061

    Catalog No. A18450
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    MDM2 inhibitor
    MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity. 了解更多
  17. BC-1215
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    BC-1215

    Catalog No. A18605
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    FBXO3 inhibitor
    BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release). BC-1215 decreases Fbxo3-Fbxl2 interaction and prevents SCFFbxo3 catalyzed Fbxl2 ubiquitination. 了解更多
  18. Pamiparib
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    Pamiparib

    Catalog No. A17073
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    PARP 抑制剂
    Pamiparib也称为BGB-290，是一种高效的，选择性的PARP抑制剂，具有良好的药物代谢和药代动力学特性。 了解更多
  19. CY-09
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    CY-09

    Catalog No. A16924
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    NLRP3 抑制剂
    CY-09是NLRP3抑制剂，Kd值为500 nM。它直接与NLRP3 NACHT域的ATP结合基序结合。 了解更多
  20. KJ Pyr 9
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    KJ Pyr 9

    Catalog No. A16324
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    MYC 抑制剂
    KJ Pyr 9是来自Krhnke吡啶库的MYC的新型小分子抑制剂KJ-Pyr-9。 了解更多
  21. (+)-ITD 1
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    (+)-ITD 1

    Catalog No. A16073
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    TGF-β 抑制剂
    (+)-ITD 1 是ITD-1的拆分对映异构体，与外消旋ITD-1相比，其TGF-β抑制作用（?400 nM）增加了2倍以上，在心脏发生方面增加了1.3倍。 了解更多
  22. HG6-64-1
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    HG6-64-1

    Catalog No. A16022
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    B-Raf 抑制剂
    HG6-64-1是有效的选择性B-Raf和突变B-Raf抑制剂；更多信息可以在专利WO 2011090738中找到。 了解更多
  23. mTOR inhibitor (mTOR-IN-1)
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    mTOR inhibitor (mTOR-IN-1)

    Catalog No. A15175
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    mTOR 抑制剂
    mTOR inhibitor (mTOR-IN-1)是mTOR的有效且选择性的ATP竞争性抑制剂，Ki为1.5 nM。 了解更多
  24. E-3810
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    E-3810

    Catalog No. A15073
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    VEGFR/FGFR 抑制剂
    E-3810是一种有效且选择性的VEGF和FGF受体双重抑制剂，对VEGFR-1，VEGFR-2，VEGFR-3，FGFR-1和VEGF的IC50值分别为7nM，25nM，10nM，17.5nM和82.5nM。FGFR-2。 了解更多
  25. LDC000067
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    LDC000067

    Catalog No. A14273
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    CDK 抑制剂
    LDC000067是一种高选择性CDK9抑制剂。 了解更多
  26. Sivelestat sodium salt
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    Sivelestat sodium salt

    Catalog No. A14073
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    Neutrophil elastase 抑制剂
    Sivelestat sodium salt是一种选择性白细胞弹性蛋白酶抑制剂（IC50 = 44 nM），在一系列其他蛋白酶中均无活性。它在体外抑制NF-κB活化和LTB4诱导的中性粒细胞转运。 了解更多
  27. Pitavastatin calcium (Livalo)
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    Pitavastatin calcium (Livalo)

    Catalog No. A10737
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    HMG-CoA reductase 抑制剂
    Pitavastatin calcium (Livalo)是HMGCR（HMG-CoA还原酶）酶的竞争性抑制剂，可降低LDL胆固醇的合成。 了解更多
  28. Piroxicam (Feldene)
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    Piroxicam (Feldene)

    Catalog No. A10736
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    COX 抑制剂
    Piroxicam (Feldene)是前列腺素合成的有效抑制剂，并且是Cox-1和Cox-2抑制剂。 了解更多
  29. Pirarubicin
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    Pirarubicin

    Catalog No. A10735
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    Topoisomerase II 抑制剂
    Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II（拓扑异构酶II）相互作用并抑制DNA复制。 了解更多
  30. GDC-0349
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    GDC-0349

    Catalog No. A11443
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    mTOR 抑制剂
    GDC-0349是一种有效的，选择性的，ATP竞争性的mTOR抑制剂，Ki为3.8 nM，比作用于PI3Kα和其他266种激酶的抑制效果高790倍。 了解更多
  31. PF-04554878 (Defactinib)
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    PF-04554878 (Defactinib)

    Catalog No. A11929
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    FAK 抑制剂
    PF-04554878 (Defactinib)是一种新型FAK激酶抑制剂，可降低胰腺神经内分泌肿瘤细胞的生长并诱导其凋亡。 了解更多
  32. Bay 65-1942 HCl
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    Bay 65-1942 HCl

    Catalog No. A11338
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    IKKβ kinase 抑制剂
    Bay 65-1942 HCl是选择性靶向IKKβ激酶活性的ATP竞争性抑制剂。 了解更多
  33. Bay 65-1942
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    Bay 65-1942

    Catalog No. A11339
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    IKKβ 抑制剂
    Bay 65-1942是选择性靶向IKKβ激酶活性的ATP竞争性抑制剂。 了解更多
  34. Safinamide Mesylate (FCE28073)
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    Safinamide Mesylate (FCE28073)

    Catalog No. A10818
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    MAO 抑制剂
    Safinamide Mesylate是沙芬酰胺的甲磺酸盐，可选择性和可逆地抑制MAO-B，IC50为0.45μM。 了解更多
  35. PIK-90
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    PIK-90

    Catalog No. A10730
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    PI3K 抑制剂
    PIK-90是一种合成的磷酸肌醇3激酶（PI3K）抑制剂，对于p110α，β，γ和δ亚型的IC50值（nM）为11、350、18和58，mTOR活性低。 了解更多
  36. Nitisinone
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    Nitisinone

    Catalog No. A11093
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    HPPD 抑制剂
    Nitrisinone是一种竞争性抑制剂，可逆地抑制4-羟基苯基丙酮酸氧化酶（双加氧酶）。 了解更多
  37. GSK256066
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    GSK256066

    Catalog No. A11073
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    PDE 抑制剂
    GSK256066是PDE4的极高亲和力和选择性抑制剂，它以相等的亲和力抑制PDE4亚型A-D，并具有很高的HARBS（高亲和力利普兰结合位点）比率（> 17）。 了解更多
  38. Pimobendan (Vetmedin)
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    Pimobendan (Vetmedin)

    Catalog No. A10733
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    PDE 抑制剂
    Pimobendan (Vetmedin)是一种钙增敏剂，具有正性肌力和血管舒张作用。它也是磷酸二酯酶III（PDE3）的选择性抑制剂。 了解更多
  39. CP-690550 (Tofacitinib citrate)
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    CP-690550 (Tofacitinib citrate)

    Catalog No. A10241
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    JAK3 抑制剂
    CP-690550 (Tofacitinib citrate)是口服的高选择性Janus激酶（JAK）酶抑制剂。 了解更多
  40. PIK-93
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    PIK-93

    Catalog No. A10731
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    PI3K 抑制剂
    PIK-93是第一个有效的，人工合成的PI4K(PI4KIIIβ)抑制剂，IC50为19 nM；抑制PI3Kα，IC50为39 nM。 了解更多
  41. PLX4032 (Vemurafenib)
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    PLX4032 (Vemurafenib)

    Catalog No. A10739
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    Raf 抑制剂
    PLX4032(Vemurafenib)也称为RG7204，Vemurafenib，R7204，RO5185426。PLX4032是B-raf抑制剂，IC50为44 nM。 了解更多
  42. XL184 free base (Cabozantinib)
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    XL184 free base (Cabozantinib)

    Catalog No. A10996
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    VEGFR 抑制剂
    XL184 free base (Cabozantinib)是设计用来抑制多种受体酪氨酸激酶（特别是MET和VEGFR2）的小分子。 了解更多

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