“jwh 249”的搜索结果

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  1. Indotecan

    Catalog No. A20979
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    Top1 inhibitor
    Indotecan (LMP-400) is a potent topoisomerase 1(Top1) inhibitor with IC50 values of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. 了解更多
  2. Sch-42495 racemate

    Catalog No. A21408
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    NEP inhibitor
    Sch-42495 racemate is the racemate of Sch-42495. Sch-42495 is a novel neutral metalloendopeptidase (NEP) inhibitor. Sch-42495 is the orally active ethylester prodrug of SCH 42354. 了解更多
  3. (R)-Zanubrutinib

    Catalog No. A21342
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    BTK inhibitor
    (R)-Zanubrutinib is the R enantiomer of Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (BTK) inhibitor. 了解更多
  4. Avibactam sodium

    Catalog No. A17306
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    non-β-lactam β-lactamase inhibitor
    Avibactam sodium (NXL-104) is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively. 了解更多
  5. Apatinib

    Catalog No. A17249
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    tyrosine kinase inhibitor
    Apatinib (YN968D1) is an orally bioavailable tyrosine kinase inhibitor, which selectively targets VEGFR-2 with an IC50 of 1 nM. 了解更多
  6. MBP146-78

    Catalog No. A12491
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    PKG inhibitor
    MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases. 了解更多
  7. DprE1-IN-2

    Catalog No. A12495
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    DprE1 inhibitor
    DprE1-IN-2 (compound 18) is a potent DprE1 inhibitor with an IC50 of 28 nM. DprE1-IN-2 has antituberculosis effect. 了解更多
  8. BCR-ABL-IN-1

    Catalog No. A12496
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    BCR-ABL inhibitor
    BCR-ABL-IN-1 is an inhibitor of BCR-ABL tyrosine kinase, with a pIC50 of 6.46, and may be used in the research of chronic myelogenous leukemia. 了解更多
  9. MBM-17

    Catalog No. A12499
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    Nek2 inhibitor
    MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. 了解更多
  10. Norverapamil hydrochloride

    Catalog No. A12249
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    P-gp inhibitor
    Norverapamil hydrochloride ((??)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. 了解更多
  11. SID 3712249

    Catalog No. A12286
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    miR-544 inhibitor
    SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). 了解更多
  12. BAY885

    Catalog No. A13765
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    ERK5 inhibitor
    BAY885 is a novel ERK5 inhibitor. 了解更多
  13. 4E2RCat

    Catalog No. A12337
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    eIF4E-eIF4G interaction inhibitor
    4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. 了解更多
  14. MD2-TLR4-IN-1

    Catalog No. A18452
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    MD2-TLR4 inhibitor
    MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. 了解更多
  15. PROTAC MDM2 Degrader-4

    Catalog No. A18877
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    MDM2 inhibitor
    PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多
  16. PROTAC MDM2 Degrader-2

    Catalog No. A18890
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    MDM2 inhibitor
    PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多
  17. Syncytial Virus Inhibitor-1

    Catalog No. A19053
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    RSV fusion inhibitor
    Syncytial Virus Inhibitor-1 is a potent, orally bioavailable respiratory syncytial virus (RSV) fusion inhibitor with EC50s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively. 了解更多
  18. BJE6-106

    Catalog No. A18627
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    PKCδ inhibitor
    BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). 了解更多
    • 最新产品

    NPI64

    Catalog No. A17220
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    Protease inhibitor
    NPI64 is a broad-spectrum coronavirus protease inhibitor which inhibits viral 3C and 3C-like protease. 了解更多
  19. Nedisertib

    Catalog No. A17055
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    DNA-PK 抑制剂
    Nedisertib (M-3814,MSC2490484A)是一种可口服的DNA依赖性蛋白激酶(DNA-PK)抑制剂,具有潜在的抗肿瘤和化学/放射增敏活性。 了解更多
  20. Azacosterol

    Catalog No. A13295
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    24-DHCR 抑制剂
    Azacosterol可作为24-脱氢胆固醇还原酶(24-DHCR)的抑制剂,可防止去甾醇形成胆固醇。 了解更多
  21. FLT3-IN-1

    Catalog No. A16249
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    FLT3 抑制剂
    FLT3-IN-1是一种新型的有效选择性Flt3抑制剂,IC50为10 nM。抗表达FLT3-ITD的MV4-11细胞,IC50为6 nM。 了解更多
  22. Diflunisal

    Catalog No. A16166
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    COX 抑制剂
    Diflunisal是具有止痛和抗炎活性的水杨酸衍生物。 了解更多
  23. ALW-II-41-27

    Catalog No. A12493
    Eph receptor 抑制剂
    ALW-II-41-27是新型的Eph受体酪氨酸激酶抑制剂。 了解更多
  24. AMG 548

    Catalog No. A10970
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    p38 MAPK 抑制剂
    AMG 548是有效的p38α选择性抑制剂。它对其他36种激酶表现出> 1000倍的选择性,并且抑制全血LPS刺激的TNFα。 了解更多
  25. NG52

    Catalog No. A12494
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    Cell cycle-regulating kinase 抑制剂
    NG52 (Compound 52)是细胞周期调节激酶Cdc28p(IC50 = 7 μM)和相关Pho85p激酶(IC50 = 2 μM)的有效,可渗透细胞,可逆,选择性和ATP兼容的抑制剂。 了解更多
  26. NFAT Inhibitor

    Catalog No. A15381
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    NFAT 抑制剂
    NFAT Inhibitor是钙调神经磷酸酶介导的活化T细胞核因子(NFAT)的去磷酸化的选择性抑制剂。 了解更多
  27. CEP-32496 hydrochloride

    Catalog No. A15040
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    Raf 抑制剂
    CEP-32496 hydrochloride是野生型BRAF,V600E突变型BRAF和c-Raf的高效抑制剂,Kd值分别为14 nM,36 nM和39 nM。 了解更多
  28. TNP-470

    Catalog No. A14014
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    MetAP-2 抑制剂
    TNP 470是富马西林的类似物,在体外显示有效的抗血管生成活性。已显示出抑制MetAP-2(甲硫氨酸氨基肽酶II型)的作用。 了解更多
  29. CEP-32496

    Catalog No. A13772
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    Raf 抑制剂
    CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1(B-raf)丝氨酸/苏氨酸蛋白激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  30. PFK-158

    Catalog No. A14398
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    PFK-2/FBPase 抑制剂
    PFK-158是6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶(PFK-2/FBPase)同工型3(PFKFB3)的抑制剂,是3-(3-吡啶基)-1-[4-吡啶基]-2-丙烯-1-酮(3PO),具有潜在的抗肿瘤活性。 了解更多
  31. SH-4-54

    Catalog No. A14249
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    Stat 抑制剂
    SH-4-54是一种有效的STAT抑制剂,对STAT3和STAT5的KD为300 nM和464 nM。 了解更多
  32. Pirarubicin

    Catalog No. A10735
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    Topoisomerase II 抑制剂
    Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II(拓扑异构酶II)相互作用并抑制DNA复制。 了解更多
  33. SNS-314

    Catalog No. A10851
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    Aurora 抑制剂
    SNS-314 Mesylate是Aurora A,Aurora B和Aurora C的有效和选择性抑制剂,IC50分别为9 nM,31 nM和3 nM。 它对Trk A/B,Flt4,Fms,Axl,c-Raf和DDR2的效力较低。 阶段1。 了解更多
  34. NVP-BSK805

    Catalog No. A11193
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    JAK 抑制剂
    NVP-BSK805是喹喔啉JAK2抑制剂对红细胞增多症的有效和选择性抑制,喹喔啉JAK2抑制剂可有效抑制小鼠和大鼠中重组人促红细胞生成素诱导的红细胞增多症和髓外红细胞生成。IC50为0.5 nM,比作用于JAK1, JAK3和TYK2选择性高20倍以上。 了解更多
  35. Cyclopamine

    Catalog No. A10249
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    Hedgehog signaling 抑制剂
    Cyclopamine是一种特异性的Hedgehog (Hh)信号通路拮抗剂,作用于Smoothened (Smo),IC50为46 nM。Cyclopamine 抑制Hedgehog信号通路, IC50 为46 nM。 了解更多

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