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搜索结果：“ab fubinaca”

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SEL120-34A HCl

Catalog No. A21485
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CDK8 inhibitor

SEL120-34A HCl is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. 了解更多

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TAK-960 hydrochloride

Catalog No. A21703
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PLK1 inhibitor

TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. 了解更多

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GDC-0575 dihydrochloride

Catalog No. A21567
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CHK1 inhibitor

GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is an orally bioavailable CHK1 inhibitor, with an IC50 of 1.2 nM, and has antitumor activity. 了解更多

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CCT241736

Catalog No. A21097
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dual FLT3/Aurora kinase inhibitor

CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor. 了解更多

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MSC2530818

Catalog No. A12644
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CDK8 inhibitor

MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8. 了解更多

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Abemaciclib Metabolites M2

Catalog No. A18416
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CDK4/CDK6 inhibitor

Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity. 了解更多

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AMG-510 racemate

Catalog No. A18752
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KRAS G12C covalent inhibitor

AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity. 了解更多

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CCT245737

Catalog No. A17239
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CHK1 inhibitor

CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%. 了解更多

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LY2835219 methanesulfonate

Catalog No. A16386
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CDK4/6 抑制剂

LY2835219是一种有效且选择性的CDK4和CDK6抑制剂，在无细胞试验中的IC50分别为2 nM和10 nM。了解更多

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ML-098

Catalog No. A15925
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Rab7 activator

ML-098是GTP结合蛋白Rab7的激活剂（EC50 = 77.6 nM）。了解更多

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XL-228

Catalog No. A13069
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IGF-1R, Aurora, FGFR, ABL, SRC 抑制剂

XL228是靶向IGF1R，AURORA激酶，FGFR1-3，ABL和SRC家族激酶的蛋白激酶抑制剂。XL228是一种Aurora A抑制剂（IC50，f3 nmol/L），对ABL1（Ki，5 nmol/L）以及BCR-ABL1 T315I（Ki，1.4 nmol/L）激酶显示出有效的生化活性。了解更多

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LY2835219 (abemaciclib)

Catalog No. A12989
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CDK4/6 抑制剂

LY2835219 (abemaciclib)是一种细胞周期蛋白依赖性激酶（CDK）抑制剂，靶向CDK4（cyclin D1）和CDK6（cyclin D3）细胞周期途径，具有潜在的抗肿瘤活性。了解更多

Product Citations (7)

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- Yoshinori Tanaka, .et al. Abemaciclib and Vacuolin-1 induce vacuole-like autolysosome formation - A new tool to study autophagosome-lysosome fusion, Biochem Biophys Res Commun, 2022, Jul 23;614:191-97 PMID: 35598430
- Sumire Suzuki, .et al. Lysosome-targeted drug combination induces multiple organelle dysfunctions and non?canonical death in pancreatic cancer cells, Oncol Rep, 2022, Feb;47(2):40 PMID: 34958115
- Kana Nakatani, .et al. Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells, Int J Hematol, 2020, Oct 17 PMID: 33068248
- Ryohei Ogata, .et al. Resistance to cyclin-dependent kinase (CDK) 4/6 inhibitors confers cross-resistance to other CDK inhibitors but not to chemotherapeutic agents in breast cancer cells, Breast Cancer, 2020, Aug 28 PMID: 32860163
- Elaheh Seyed Abutorabi, .et al. Abemaciclib (CDK4/6 Inhibitor) Blockade Induces Cytotoxicity in Human Anaplastic Thyroid Carcinoma Cells, Rep Biochem Mol Biol, 2020, Jan; 8(4): 438-445 PMID: 32582803
- Hidemasa Matsuo, .et al. Recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia, Blood Adv, 2018, Nov 13; 2(21): 2879-2889 PMID: 30381403
- Iriyama N, .et al. The cyclin-dependent kinase 4/6 inhibitor, abemaciclib, exerts dose-dependent cytostatic and cytocidal effects and induces autophagy in multiple myeloma cells, Leuk Lymphoma, 2018, Jun;59(6):1439-1450 PMID: 28918692
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TAK-901

Catalog No. A11067
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Aurora Kinase A/B 抑制剂

TAK-901是一种新型Aurora A/B抑制剂，IC50为21 nM/15 nM。它不是细胞JAK2，c-Src或Abl的有效抑制剂。了解更多

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KW-2449

Catalog No. A10508
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FLT3/FGFR/Bcr-Abl/Aurora 抑制剂

KW-2449是FLT3、ABl、ABl-T315I和Aurora激酶的多激酶抑制剂。了解更多

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Danusertib (PHA-739358)

Catalog No. A10715
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Aurora 抑制剂

Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂，在无细胞分析中的IC50为13 nM/79nM/61 nM，对Abl，TrkA，c-RET和FGFR1以及更低的浓度具有中等效力对Lck，VEGFR2/3，c-Kit，CDK2等有效。了解更多

Product Citations (1)

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- Samuel Q. Li, etc. Targeting Wild-Type and Mutationally Activated FGFR4 in Rhabdomyosarcoma with the Inhibitor Ponatinib (AP24534). PLoS One. 2013; 8(10): e76551.

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