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搜索结果：“jwh 249”

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Demethoxycurcumin

Catalog No. A14545
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Demethoxycurcumin是姜黄素的天然脱甲氧基衍生物。了解更多

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Bisdemethoxycurcumin

Catalog No. A14544
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Bisdemethoxycurcumin是姜黄素的天然去甲氧基衍生物。了解更多

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CEP-32496

Catalog No. A13772
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Raf 抑制剂

CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1（B-raf）丝氨酸/苏氨酸蛋白激酶抑制剂，具有潜在的抗肿瘤活性。了解更多

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PFK-158

Catalog No. A14398
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PFK-2/FBPase 抑制剂

PFK-158是6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶（PFK-2/FBPase）同工型3（PFKFB3）的抑制剂，是3-(3-吡啶基)-1-[4-吡啶基]-2-丙烯-1-酮(3PO)，具有潜在的抗肿瘤活性。了解更多

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SH-4-54

Catalog No. A14249
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Stat 抑制剂

SH-4-54是一种有效的STAT抑制剂，对STAT3和STAT5的KD为300 nM和464 nM。了解更多

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SB225002

Catalog No. A14209
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CXCR2 拮抗剂

SB225002是一种有效的选择性CXCR2拮抗剂，IC50为22 nM，可抑制白介素IL-8与CXCR2的结合，选择性是其他测试的7-TMR的150倍以上。了解更多

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SB 334867

Catalog No. A12786
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OX1 receptor 拮抗剂

SB 334867是一种选择性的非肽orexin OX1受体拮抗剂。对于分别表达人OX1和OX2受体的CHO细胞中的细胞内Ca2 +释放抑制，pKb值为7.2和<5。体内全身给药后，阻断orexin-A诱导的美容和进食。了解更多

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- Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882
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Pirarubicin

Catalog No. A10735
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Topoisomerase II 抑制剂

Pirarubicin是蒽环类抗肿瘤阿霉素的类似物。插入DNA中并与Topo II（拓扑异构酶II）相互作用并抑制DNA复制。了解更多

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- Krishna K Ramajayam, .et al. Selecting ideal drugs for encapsulation in thermosensitive liposomes and other triggered nanoparticles, Int J Hyperthermia, 2022, 39(1):998-1009 PMID: 35876089
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Anamorelin

Catalog No. A12346
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Anamorelin是一种新型 ghrelin receptor激动剂，FLIPR 检测中，EC50 为 0.74 nM，用于治疗与恶病质/厌食症相关的非小肺癌。了解更多

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- Josua Jordi, .et al. High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy, Sci Adv, 2018, Oct; 4(10): eaav1966 PMID: 30402545
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Varenicline

Catalog No. A10966
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nAChR partial agonist

Varenicline是烟碱样受体部分激动剂。了解更多

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Tolterodine tartrate (Detrol LA)

Catalog No. A10937
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muscarinic receptor 拮抗剂

Tolterodine tartrate (Detrol LA)是毒蕈碱受体拮抗剂。了解更多

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Gastrodin (Gastrodine)

Catalog No. A10418
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Gastrodin (Gastrodine)是一种多酚。它是4-羟基苯甲醇(天麻素)的糖苷。了解更多

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NVP-BSK805

Catalog No. A11193
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JAK 抑制剂

NVP-BSK805是喹喔啉JAK2抑制剂对红细胞增多症的有效和选择性抑制，喹喔啉JAK2抑制剂可有效抑制小鼠和大鼠中重组人促红细胞生成素诱导的红细胞增多症和髓外红细胞生成。IC50为0.5 nM，比作用于JAK1， JAK3和TYK2选择性高20倍以上。了解更多

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