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“jwh 018”的搜索结果

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  1. NS-018 maleate
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    NS-018 maleate

    Catalog No. A16226
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    JAK2 抑制剂
    NS-018 maleate是在Ba/F3-JAK2V617F细胞中具有ATP竞争性的JAK2小分子抑制剂，IC50为470nM。与其他JAK家族激酶（例如JAK1，JAK3和酪氨酸激酶2）相比，对JAK2的选择性高30-50倍。 了解更多
  2. NS-018 hydrochloride
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    NS-018 hydrochloride

    Catalog No. A16225
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    JAK2 抑制剂
    NS-018 hydrochloride是一种新型的高选择性JAK2抑制剂。 了解更多
  3. NS-018
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    NS-018

    Catalog No. A16224
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    JAK2 抑制剂
    NS-018是Janus相关激酶2（JAK2）和Src家族激酶的口服生物利用型小分子抑制剂，具有潜在的抗肿瘤活性。 了解更多
  4. GNE-955
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    GNE-955

    Catalog No. A19243
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    Pim kinase inhibitor
    GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively. 了解更多
  5. HDAC-IN-3
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    HDAC-IN-3

    Catalog No. A20785
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    HDAC inhibitor
    HDAC-IN-3 is a histone deacetylase (HDAC) inhibitor, extracted from patent WO/2008040934 A1. 了解更多
  6. YF-2
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    YF-2

    Catalog No. A21018
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    histone acetyltransferase activator
    YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease. 了解更多
  7. OICR-0547
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    OICR-0547

    Catalog No. A20877
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    Wdr5-MLL interaction antagonist
    OICR-0547 is a closely related derivative of OICR-9429. OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction, while OICR-0547 cannot bind to WDR5. 了解更多
  8. Niraparib hydrochloride
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    Niraparib hydrochloride

    Catalog No. A18018
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    PARP1 and PARP2 inhibitor
    Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. 了解更多
  9. BRD-6929
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    BRD-6929

    Catalog No. A12511
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    HDAC1/HDAC2 inhibitor
    BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50=?1 and 8 nM), extracted from patent US2018360927. 了解更多
  10. Ruxolitinib sulfate
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    Ruxolitinib sulfate

    Catalog No. A11467
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    JAK1/2 inhibitor
    Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3. 了解更多
  11. TPOP146
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    TPOP146

    Catalog No. A12655
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    CBP/P300 benzoxazepine bromodomain inhibitor
    TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. 了解更多
  12. JAK1-IN-7
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    JAK1-IN-7

    Catalog No. A19029
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    JAK1 抑制剂
    JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor extracted from patent WO2018134213A1, Example 63, has an anti-inflammatory effect. 了解更多
  13. Ruxolitinib Phosphate
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    Ruxolitinib Phosphate

    Catalog No. A11552
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    JAK 抑制剂
    Ruxolitinib Phosphate是ruxolitinib的磷酸盐形式，ruxolitinib是一种口服生物可利用的Janus相关激酶(JAK)抑制剂，具有潜在的抗肿瘤和免疫调节活性。 了解更多
  14. TCS 21311
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    TCS 21311

    Catalog No. A15365
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    JAK3 抑制剂
    TCS 21311是有效的JAK3抑制剂（IC50 = 8 nM）。TCS 21311对于JAK3相对于JAK1，JAK2和Tyk 2具有选择性（IC50值分别为1017、2550和8055 nM）。 了解更多
  15. S-Ruxolitinib
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    S-Ruxolitinib

    Catalog No. A14955
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    JAK 抑制剂
    S-Ruxolitinib是INCB018424的手性化合物，是一种有效且选择性的小分子Janus激酶1（JAK1）和JAK2抑制剂。 了解更多
  16. CCT129202
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    CCT129202

    Catalog No. A10184
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    Aurora 抑制剂
    CCT129202是一种ATP竞争性的pan-Aurora抑制剂，作用于Aurora A，Aurora B和Aurora C时，IC50分别为0.042 μM，0.198 μM和0.227 μM，对FGFR3， GSK3β， PDGFRβ等作用效果稍弱。 了解更多
  17. INCB018424 (Ruxolitinib)
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    INCB018424 (Ruxolitinib)

    Catalog No. A11041
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    JAK1/2 抑制剂
    INCB018424 (Ruxolitinib)是有效和选择性的Janus相关激酶JAK1/2抑制剂，对JAK1，JAK2和JAK3的IC50分别为2.7、4.5和332 nM。 了解更多

17 个项目

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分类
  1. HDAC (2)
  2. PARP (1)
  3. JAK (9)
  4. Pim (1)
  5. Aurora Kinase (1)
  6. Epigenetic Reader Domain (1)
  7. Histone Acetyltransferases (2)
  8. Histone Methyltransferase (1)
作用机制
  1. Inhibitor (抑制剂) (13)
  2. Antagonist (拮抗剂) (1)
  3. Activator (激活剂) (1)
靶点
  1. Aurora A (1)
  2. Aurora B (1)
  3. Aurora C (1)
  4. HDAC1 (1)
  5. HDAC2 (1)
  6. JAK1 (2)
  7. JAK2 (5)
  8. JAK3 (1)
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