“ab fubinaca”的搜索结果

产品 1 到 50 共 69个

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  1. Tebanicline hydrochloride

    Catalog No. A21918
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    nAChR modulator
    Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. 了解更多
  2. Rislenemdaz

    Catalog No. A21907
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    NMDA receptor GluN2B antagonist
    Rislenemdaz (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC50 of 8.1 nM and 3.6 nM, respectively. 了解更多
  3. Etoricoxib D4

    Catalog No. A21877
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    COX-2 inhibitor
    Etoricoxib D4 (MK-0663 D4) is a deuterium labeled Etoricoxib. Etoricoxib is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. 了解更多
  4. THIP

    Catalog No. A21738
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    δ-GABAAR agonist
    THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist. 了解更多
  5. Gaboxadol hydrochloride

    Catalog No. A21730
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    GABAA receptors agonist
    Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects. 了解更多
  6. SCH 50911

    Catalog No. A21630
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    γ-Aminobutyric acid B GABA(B) receptor antagonist
    SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist. 了解更多
  7. AZD3839 free base

    Catalog No. A21606
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    BACE1 inhibitor
    AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor. 了解更多
  8. Elinogrel

    Catalog No. A21468
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    platelet P2Y12 antagonist
    Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y12 antagonist (IC50=20 nM). It is orally and intravenously available and has potent antiplatelet effects. 了解更多
  9. (R)-Rivastigmine D6 tartrate

    Catalog No. A21454
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    cholinesterase inhibitor
    (R)-Rivastigmine D6 (tartrate) is the deuterium labeled (R)-Rivastigmine, which is an cholinesterase inhibitor. 了解更多
  10. NS11394

    Catalog No. A21425
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    GABA(A) receptor modulator
    NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors. 了解更多
  11. CP-409092 hydrochloride

    Catalog No. A21397
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    GABAA receptor partial agonist
    CP-409092 hydrochloride is a partial agonist of GABAA receptor, with anti-anxiety activity. 了解更多
  12. Basmisanil

    Catalog No. A21321
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    GABAAα5 modulator
    Basmisanil is a highly selective GABAAα5 negative allosteric modulator. 了解更多
  13. L-655708

    Catalog No. A21181
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    GABAA receptor inverse agonist
    L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM). 了解更多
  14. (R)-Baclofen

    Catalog No. A16680
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    GABAB receptor agonist
    (R)-Baclofen(STX209) is a selective GABAB receptor agonist. 了解更多
  15. U-101017

    Catalog No. A13357
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    Benzodiazepine receptor/GABAA receptor agonist
    U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects. 了解更多
  16. Acamprosate calcium

    Catalog No. A11308
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    GABA receptor agonist
    Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. 了解更多
  17. Lanabecestat

    Catalog No. A12282
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    BACE1 inhibitor
    Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多
  18. Gabazine

    Catalog No. A12627
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    GABAA receptor antagonist
    Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor. 了解更多
  19. Naproxen etemesil

    Catalog No. A13052
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    COX-1 and COX-2 inhibitor
    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. 了解更多
  20. MRK-016

    Catalog No. A12046
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    GABAA α5 receptor agonist
    MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS. 了解更多
  21. GNE 0723

    Catalog No. A12757
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    NMDAR modulator
    GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. 了解更多
  22. RWJ-51204

    Catalog No. A12875
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    partial agonist of GABA(A) receptor
    RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors. 了解更多
  23. TPA 023

    Catalog No. A20140
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    GABAA α2/α3 agonist
    TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM. 了解更多
  24. CP-409092

    Catalog No. A20152
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    GABAA receptor partial agonist
    CP-409092 is a partial agonist of GABAA receptor, with anti-anxiety activity. 了解更多
  25. BNC375

    Catalog No. A18503
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    α7 nAChR Modulator
    BNC375 is a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. 了解更多
  26. CGP 36742

    Catalog No. A18666
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    GABAB receptor antagonist
    CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood?Cbrain barrier after peripheral administration, with an IC50 of 32?μM. CGP 36742 is useful in treatment of depression. 了解更多
  27. Cimetropium Bromide

    Catalog No. A18290
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    mAChR antagonist
    Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome. 了解更多
  28. Baclofen

    Catalog No. A18248
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    GABA agonist
    Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. 了解更多
  29. Homotaurine

    Catalog No. A17944
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    GABA receptor agonist
    Tramiprosate, also known as homotaurine, is a gamma-Aminobutyric acid (GABA) receptor agonist and a glycosaminoglycan mimetic used in the treatment of Alzheimer's disease. 了解更多
  30. Cangrelor Tetrasodium

    Catalog No. A17919
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    P2Y12 receptors inhibitor
    Cangrelor Tetrasodium is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. Unlike clopidogrel (Plavix), which is a prodrug, cangrelor is an active drug not requiring metabolic conversion. 了解更多
  31. Afloqualone

    Catalog No. A17276
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    GABA receptor agonist
    Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. 了解更多
  32. Cgp 52432

    Catalog No. A17140
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    GABA-A receptor 拮抗剂
    Cgp 52432是GABA-A受体拮抗剂。 了解更多
  33. NGP-555

    Catalog No. A17051
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    γ-Secretase Modulator
    NGP-555是一种γ-分泌酶调节剂,具有选择性机制,可减少Abeta 42,同时提高较短的Abeta形式,例如Abeta 37和38。 了解更多
  34. (-)-Securinine

    Catalog No. A17102
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    GABA receptor 拮抗剂
    (-)-Securinine是一种最初从S. suffructicosa分离的生物碱。Securinine是一种特定的GABA受体拮抗剂,已发现在体内具有显着的CNS活性。 了解更多
  35. Bamaluzole

    Catalog No. A17107
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    GABA receptor 激动剂
    Bamaluzole是GABA受体激动剂。 了解更多
  36. U-93631

    Catalog No. A16336
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    GABAA receptor ligand
    U-93631是具有新颖化学结构的GABAA受体配体,IC50为100 nM,并且已显示在重组GABAA受体中诱导GABA诱导的全细胞Cl-电流快速,时间依赖性地衰减。 了解更多
  37. Lorediplon

    Catalog No. A13449
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    GABAA receptor modulator
    Lorediplon 是一种新型的非苯二氮卓类催眠药,作为GABAA受体调节剂。 了解更多
  38. Piperazine

    Catalog No. A16171
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    GABA receptor 激动剂
    Piperazine是由六元环组成的有机化合物,该六元环在环的相对位置包含两个氮原子。 了解更多
  39. Tiagabine hydrochloride

    Catalog No. A16135
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    GABA reuptake 抑制剂
    Tiagabine hydrochloride是一种抗惊厥药。该药物还用于治疗惊恐症,还有其他一些抗惊厥药。 了解更多
  40. Picrotoxin

    Catalog No. A14004
    GABAA receptor 拮抗剂
    Picrotoxin是GABAA受体拮抗剂。该化合物已显示可增加下丘脑的去甲肾上腺素水平和周转率。 了解更多
  41. Tiagabine

    Catalog No. A13198
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    GABA reuptake 抑制剂
    Tiagabine是一种选择性γ-氨基丁酸(gaba)再摄取抑制剂。 了解更多
  42. CTP354

    Catalog No. A15939
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    GABA(A) modulator
    CTP354是一种新型的氘化亚型选择性GABA(A)调节剂。 了解更多
  43. Amyloid b-Peptide (1-40) (human)

    Catalog No. A15418
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    Amyloid b-Peptide (1-40) (human)是由淀粉样前体蛋白(APP)加工而成的肽。 了解更多
  44. MRK 560

    Catalog No. A15304
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    γ-secretase 抑制剂
    MRK 560是一种可用的γ-分泌酶抑制剂,能够显着减少大鼠脑和CSF中的Abeta肽,并证实该大鼠可用于评估γ-分泌酶抑制剂对中枢神经系统Abeta的作用(40)体内水平。 了解更多
  45. Vigabatrin

    Catalog No. A15277
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    GABA-transaminase 抑制剂
    Vigabatrin是抑制性神经递质β-氨基丁酸(GABA)的结构类似物,它不可逆地抑制GABA转氨酶对GABA的分解代谢。 了解更多
  46. Etifoxine hydrochloride

    Catalog No. A15084
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    Anxiolytic anticonvulsant
    Etifoxine hydrochloride是培养的神经元中GABAA受体功能的增强剂。 了解更多
  47. Etifoxine

    Catalog No. A15083
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    Anxiolytic anticonvulsant
    Etifoxine是培养的神经元中GABAA受体功能的增强剂。 了解更多
  48. 4-Aminobutyric acid

    Catalog No. A14934
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    4-Aminobutyric acid是哺乳动物中枢神经系统的主要抑制性神经递质。 了解更多
  49. Muscimol hydrobromide

    Catalog No. A13459
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    GABA(A) receptor 激动剂
    Muscimol hydrobromide是抗抑郁药氟西汀的活性代谢产物,可抑制5-羟色胺的摄取,pKi值为7.35.1。诺氟西汀的S-对映体的5-羟色胺再摄取阻断效能比R-对映体高20倍(分别为pKis = 7.86与6.51)。 了解更多
  50. Guvacine hydrochloride

    Catalog No. A13613
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    GABA uptake 抑制剂
    Guvacine hydrochloride可抑制GABA的摄取(hGABA T-1,rGABA T-2,hGABA T-3和hBGT-1的IC50值分别为14、58、119和1870 uM)。 了解更多

产品 1 到 50 共 69个

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