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搜索结果：“jwh 250”

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AMG 487

Catalog No. A21162
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CXCR3 antagonist

AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. 了解更多

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UNBS5162

Catalog No. A15439
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CXCL chemokines 拮抗剂

UNBS5162是一种新型萘二甲酰亚胺，可降低实验性前列腺癌中CXCL趋化因子的表达。9种癌细胞系的平均抗增殖活性IC50值为17.9 uM；UNBS3157的水解产物。了解更多

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SBC-115076

Catalog No. A15769
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PCSK9 拮抗剂

SBC-115076是抗蛋白原转化酶枯草杆菌蛋白酶kexin 9型（抗PCSK9）化合物，用于治疗和/或预防心血管疾病。了解更多

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Spautin-1

Catalog No. A12942
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Autophagy 抑制剂

Spautin-1是一种新型的自噬抑制剂，IM抑制K562细胞的生长，IC50为1.03μM。相反，与Spautin-1共同处理可增加IM诱导的细胞活力抑制，IC50为0.45μM。了解更多

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- Yoon-Jin Kim, .et al. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system, Sci Adv, 2021, Feb 19;7(8) PMID: 33608268
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SB225002

Catalog No. A14209
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CXCR2 拮抗剂

SB225002是一种有效的选择性CXCR2拮抗剂，IC50为22 nM，可抑制白介素IL-8与CXCR2的结合，选择性是其他测试的7-TMR的150倍以上。了解更多

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WZ811

Catalog No. A12588
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CXCR4 拮抗剂

WZ811是4型C-X-C趋化因子受体（CXCR4）拮抗剂（EC50 = 0.3 nM）。在体外抑制CXCR4/基质细胞衍生因子1（SDF-1）介导的cAMP调节（EC50 = 1.2 nM）。了解更多

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SRT3109

Catalog No. A11097
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CXCR2 ligand

SRT3109是一种CXCR2配体，用于治疗趋化因子介导的疾病和状况。了解更多

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Chloroquine Phosphate

Catalog No. A16445
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Chloroquine Phosphate是一种4-氨基喹啉抗疟和抗类风湿药，也可作为ATM活化剂。了解更多

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- Egawa Y, .et al. Therapeutic potential of CPI-613 for targeting tumorous mitochondrial energy metabolism and inhibiting autophagy in clear cell sarcoma, PLoS One, 2018, Jun 7;13(6):e0198940 PMID: 29879220