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WAY 170523

Catalog No. A15317
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MMP-13 抑制剂

WAY 170523是MMP-13的选择性强效抑制剂。了解更多

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PD 166793

Catalog No. A15307
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Broad spectrum MMP 抑制剂

PD166793是一种细胞可渗透的化合物，可强烈抑制MMP（基质金属蛋白酶）-2，-3和-13，而弱抑制AMP脱氨酶，MMP-1，-7，-9和-14。了解更多

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CL-82198

Catalog No. A13597
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MMP-13 抑制剂

CL-82198是人胶原酶3（也称为基质金属蛋白酶13（MMP-13））的选择性抑制剂，在10 mg/ml时产生89％的抑制作用。了解更多

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PSI-7977

Catalog No. A11529
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HCV Nucleotide 抑制剂

PSI-7977是PSI-7851的氨基磷酸酯前药，PSI-7851是核苷类似物，当磷酸化时，抑制丙型肝炎病毒的RNA依赖性RNA聚合酶(EC50 = 92 nM)。了解更多

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- Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
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NSC 405020

Catalog No. A13072
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MT1-MMP 抑制剂

NSC-405020是一种膜1型基质金属蛋白酶（MT1-MMP）抑制剂（IC50> 100μmol/ L）。了解更多

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- Kittaka M, .et al. Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts, J Bone Miner Res, 2018, Jan;33(1):167-181 PMID: 28914985
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LY573636 (Tasisulam)

Catalog No. A13070
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Apoptosis inducer

LY573636 (Tasisulam)是一种有效的抗肿瘤剂，在体外和体内引起多种人实体瘤的生长停滞和凋亡。LY573636诱导的凋亡通过线粒体靶向机制发生。了解更多

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- Ting TC, .et al. Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15, Cell Rep, 2019, Nov 5;29(6):1499-1510.e6 PMID: 31693891
- Ting Han, .et al. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15, Science, 2017, Apr 28;356(6336). pii: eaal3755 PMID: 28302793