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搜索结果：“jwh 250”

“jwh 250”的搜索结果

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HLY78

Catalog No. A18402
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Wnt/β-catenin 激活剂

HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. 了解更多

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LF3

Catalog No. A16851
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Wnt 抑制剂

LF3通过破坏β-catenin和TCF4之间的相互作用（IC50小于2 uM）是典型Wnt信号传导的特异性抑制剂。了解更多

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ETC-159

Catalog No. A15840
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Wnt 抑制剂

ETC-159是Wnt分泌的有效和特异性抑制剂。ETC-159以剂量依赖性方式抑制β-catenin报告基因的活性，IC50为2.9 nM。了解更多

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HhAntag

Catalog No. A12418
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HhAntag是GLI1介导的转录的小分子抑制剂，GLI1介导的转录是Hedgehog（Hh）途径的重要下游元素。了解更多

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FLI-06

Catalog No. A13815
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Gamma-secretase 抑制剂

FLI-06是一种Notch抑制剂和早期分泌途径抑制剂。FLI-06以不同于布雷菲德菌素A和杀真菌剂A的方式破坏高尔基体。了解更多

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- Tan YJ, .et al. Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer, Future Med Chem, 2018, Sep 1;10(17):2039-2057 PMID: 30066578
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Wnt-C59

Catalog No. A12951
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PORCN/Wnt 抑制剂

Wnt-C59是一种非常有效且高度选择性的Wnt信号拮抗剂，在Wnt信号报告基因分析中的IC50?74 pM。了解更多

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- Laksitorini MD, .et al. Modulation of Wnt/β-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells, Sci Rep, 2019, Dec 23;9(1):19718 PMID: 31873116
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LH 846

Catalog No. A13574
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CK1 抑制剂

LH 846是酪蛋白激酶（CK）1δ的选择性抑制剂（CK1δ，ε和α的IC50值为290 nM，1.3μM和2.5μM）。了解更多

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IWR-1-endo

Catalog No. A12737
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Wnt 抑制剂

IWR-1-endo是Wnt应答的有效抑制剂，可阻断基于细胞的Wnt /β-catenin途径报道分子应答，IC50值为180 nM。 Wnt蛋白与细胞表面的受体结合，启动信号级联反应，从而导致β-catenin激活基因转录。了解更多

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- Charles A.Herring, .et al. Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution, Cell, 2022, Oct 27;S0092-8674(22)01258-2 PMID: 36318921
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TWS119

Catalog No. A11223
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GSK-3 抑制剂

TWS119是4,6双取代的吡咯并嘧啶，可有效抑制GSK3β，IC50值为30 nM。了解更多

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DAPT (GSI-IX)

Catalog No. A10288
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Gamma secretase 抑制剂

DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。了解更多

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- Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
- Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386
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MK-0752

Catalog No. A11194
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Gamma-secretase 抑制剂

MK-0752抑制Notch信号通路，这可能会导致Notch信号通路被过度激活的肿瘤细胞诱导生长停滞和凋亡。了解更多

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ICG-001

Catalog No. A11039
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Wnt/beta-catenin 抑制剂

ICG-001是Wnt/β-catenin信号传导途径的特异性抑制剂，可抑制β-catenin/环状AMP响应元件结合（CREB）蛋白的转录（IC50 = 3 uM）。了解更多

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- Seonmin Choi, .et al. Indocyanine Green-Loaded PLGA Nanoparticles Conjugated with Hyaluronic Acid Improve Target Specificity in Cervical Cancer Tumors, Yonsei Med J, 2021, Nov;62(11):1042-1051 PMID: 34672138
- Jasper C.Munro, .et al. Cardiac function and feed efficiency: increased right-heart workload in feed inefficient beef cattle, Livest Sci, 2019, 229 (2019) 159-169
- Kim JH, .et al. Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus, Cell Rep, 2019, May 14;27(7):2105-2118.e5 PMID: 31091449
- Yamaoka R, .et al. CD90 expression in human intrahepatic cholangiocarcinoma is associated with lymph node metastasis and poor prognosis, J Surg Oncol, 2018, Sep;118(4):664-674 PMID: 30196535
- Aida Y, .et al. Wnt3a promotes differentiation of human bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell Dev Biol Anim, 2018, Jun;54(6):468-476 PMID: 29785536
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Compound W

Catalog No. A15296
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Gamma-secretase modulator

Compound W是一种γ-分泌酶抑制剂，已被证明可以降低分泌的Aβ42和Nβ25的水平。了解更多

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Salinomycin sodium salt

Catalog No. A15229
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Salinomycin sodium salt 是一种钾离子载体抗生素，是Wnt/β-catenin信号传导的有效抑制剂。是一种抗菌和抗球虫药离子载体治疗药物。了解更多

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Flurizan

Catalog No. A12433
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gamma-secretase modulator

Flurizan是一种非甾体抗炎药（NSAID），可抑制γ-分泌酶的活性。了解更多

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