“ab fubinaca”的搜索结果

产品 1 到 50 共 67个

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  1. Vericiguat

    Catalog No. A21031
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    guanylate cyclase stimulator
    Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator. 了解更多
  2. Auglurant

    Catalog No. A20958
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    mGlu5 antagonist
    Auglurant (VU0424238) is a novel and selective mGlu5 antagonist with an IC50 value of 11 nM (rat) and an IC50 value of 14 nM (human). Auglurant (VU0424238) has an acceptable CNS penetration. 了解更多
  3. Aripiprazole (D8)

    Catalog No. A22004
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    human 5-HT1A receptor partial agonist
    Aripiprazole D8 (OPC-14597 D8) is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. 了解更多
  4. Aprocitentan

    Catalog No. A21999
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    dual ETA/ETB antagonist
    Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively. 了解更多
  5. Ziprasidone D8

    Catalog No. A21989
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    5-HT / dopamine receptor antagonist
    Ziprasidone D8 is deuterium labeled Ziprasidone, which is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. 了解更多
  6. Haloperidol D4'

    Catalog No. A21971
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    dopamine D2 receptor antagonist
    Haloperidol D4' is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist. 了解更多
  7. Haloperidol D4

    Catalog No. A21961
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    dopamine D2 receptor antagonist
    Haloperidol D4 is deuterium labeled haloperidol, and the latter is a potent dopamine D2 receptor antagonist. 了解更多
  8. Vilazodone D8

    Catalog No. A21876
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    SSR inhibitor / 5-HT1A receptor partial agonist
    Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. 了解更多
  9. AM-4668

    Catalog No. A21778
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    GPR40 agonist
    AM-4668 is a GPR40 agonist for type 2 diabetes. EC50s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively. 了解更多
  10. Taranabant ((1R,2R)stereoisomer)

    Catalog No. A21705
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    CB1 receptor inverse agonist
    Taranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist. 了解更多
  11. Taranabant racemate

    Catalog No. A21699
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    CB1 antagonist/inverse agonist
    Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor extracted from patent WO 2004048317 A1. 了解更多
  12. Vofopitant dihydrochloride

    Catalog No. A21543
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    NK1 receptor antagonist
    Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist. 了解更多
  13. AM-1638

    Catalog No. A21505
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    GPR40/FFA1 full agonist
    AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM. 了解更多
  14. (±)-Ibipinabant

    Catalog No. A21439
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    CB-1 receptor antagonist
    (±)-Ibipinabant ((±)-SLV319) is the racemate of SLV319. (±)-Ibipinabant ((±)-SLV319) is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM. 了解更多
  15. Masupirdine mesylate

    Catalog No. A21409
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    5-HT6 receptor antagonist
    Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). 了解更多
  16. SB-277011 dihydrochloride

    Catalog No. A21353
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    dopamine D3 receptor antagonist
    SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively. 了解更多
  17. Basimglurant

    Catalog No. A21225
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    mGlu5 negative allosteric modulator
    Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM. 了解更多
  18. L-371,257

    Catalog No. A21219
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    oxytocin receptor antagonist
    L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM). 了解更多
  19. GPR40 Activator 1

    Catalog No. A21154
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    GPR40 activator
    GPR40 Activator 1 is a potent GPR40 activator for treatment of type 2 diabetes. 了解更多
  20. Cutamesine

    Catalog No. A21152
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    sigma 1 receptor agonist
    Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(??1R) agonist; high affinity for the sigma 1 receptor subtype labeled by (+)-[3H]pentazocine (IC50= 17.4??1.9 nM); 100-fold less affinity for the sigma 2 receptor. 了解更多
  21. ADX88178

    Catalog No. A20922
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    mGluR4 PAM
    ADX88178 is a potent metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) with an EC50 of 4 nM for human mGluR4. 了解更多
  22. Cenerimod

    Catalog No. A20913
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    S1P1 agonist
    Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. 了解更多
  23. Taranabant

    Catalog No. A11578
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    CB1 receptor inverse agonist
    Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro. 了解更多
  24. Kynurenic acid sodium

    Catalog No. A20000
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    GPR35/CXCR8 agonist
    Kynurenic acid sodium, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid sodium is also an agonist of GPR35/CXCR8. 了解更多
  25. β3-AR agonist 1

    Catalog No. A12777
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    β3-adrenergic receptor agonist
    β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold). 了解更多
  26. GPR35 agonist 1

    Catalog No. A12462
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    GPR35/CXCR8 agonist
    GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good druggability. 了解更多
  27. LY2922470

    Catalog No. A12181
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    GPR40 agonist
    LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively. 了解更多
  28. AB-MECA

    Catalog No. A12189
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    A3 adenosine receptor agonist
    AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors. 了解更多
  29. CB2R-IN-1

    Catalog No. A12306
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    cannabinoid CB2 receptor inverse agonist
    CB2R-IN-1 is a potent cannabinoid CB2 receptor inverse agonist with a Ki of 0.9 nM. 了解更多
  30. SB756050

    Catalog No. A12759
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    TGR5 agonist
    SB756050 is a selective TGR5 agonist currently in phase 1clinical trials for the treatment of type 2 diabetes. 了解更多
  31. ST3932

    Catalog No. A12880
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    Adenosine A2A receptor antagonist
    ST3932 is a metabolite of ST1535, acts as an antagonist of adenosine A2A receptor, with Kis of 8 nM and 33 nM for A2A and A1 receptors, respectively. 了解更多
  32. CB1 antagonist 2

    Catalog No. A18810
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    CB1 antagonist
    CB1 antagonist 2 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3, inhibits CB1 in vivo with an IC50 of 25.5 nM. 了解更多
  33. Semaglutide

    Catalog No. A18908
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    GLP-1 receptor agonist
    Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1 (GLP-1) receptor agonist that can be used in the treatment of type 2 diabetes. 了解更多
  34. YM-264

    Catalog No. A20139
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    PAF 拮抗剂
    YM-264 is a selective, potent and orally active platelet-activating factor (PAF) antagonist with a pKi value of 8.85 for rabbit platelet membranes. 了解更多
  35. Alosetron (Hydrochloride(1:X))

    Catalog No. A11309
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    Serotonin 5HT3-receptor antagonist
    Alosetron Hydrochloride(1:X) (GR 68755 Hydrochloride(1:X)) is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome. 了解更多
  36. Kynurenic acid

    Catalog No. A16581
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    GPR35/CXCR8 拮抗剂
    Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. 了解更多
  37. KAG-308

    Catalog No. A18389
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    EP4 激动剂
    KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration. 了解更多
  38. VCE-004.8

    Catalog No. A18549
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    PPARγ and CB2 receptor dual agonist
    VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. 了解更多
  39. VU0652835

    Catalog No. A18885
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    mGlu5 modulator
    VU0652835 is a metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 of 81 nM. 了解更多
  40. Trimebutine maleate

    Catalog No. A18115
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    ?- opioid receptor agonist
    Trimebutine Maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Trimebutine Maleate modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome. 了解更多
  41. Hydroxyzine pamoate

    Catalog No. A17712
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    Histamine H1 receptor antagonist
    Hydroxyzine pamoate is an histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. 了解更多
  42. Dinoprost tromethamine

    Catalog No. A17505
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    Prostaglandin Receptor inhibitor
    Dinoprost Tromethamine, also known as Dinoprost Trometamol, is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. 了解更多
  43. Rimonabant hydrochloride

    Catalog No. A11548
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    CB1 receptor inverse 激动剂
    Rimonabant hydrochloride是CB1受体反向激动剂。 了解更多
  44. ACR 16 hydrochloride

    Catalog No. A16074
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    dopaminergic stabilizer
    ACR 16 hydrochloride是一种多巴胺能稳定剂(对于D2(低)和D2(高),Ki值分别为17550 nM和7521),通过功能性多巴胺D2受体拮抗作用和皮质谷氨酸功能的双重作用,稳定地稳定精神运动活动。在各种情况下神经传递受到干扰。 了解更多
  45. Tetrabenazine (Xenazine)

    Catalog No. A10919
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    Tetrabenazine (Xenazine)是用于过度运动障碍的对症治疗药物。 了解更多
  46. Bupropion

    Catalog No. A15850
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    NDR 抑制剂
    Bupropion是主要用作抗抑郁药和戒烟辅助药的药物。 了解更多
  47. Atrasentan HCl

    Catalog No. A15007
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    Endothelin 拮抗剂 receptor
    Atrasentan hydrochloride是一种开发用于治疗前列腺癌的内皮素拮抗剂受体(IC50 = 0.0551 nM,ETA)。 了解更多
  48. Otenabant

    Catalog No. A15200
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    CB1 receptor 拮抗剂
    Otenabant是最近发现的选择性,高亲和力,竞争性CB1受体拮抗剂,Ki为0.7 nM。 了解更多
  49. HOKU-81

    Catalog No. A15117
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    Metabolites of tulobuterol
    HOKU-81是新型支气管扩张剂,是妥洛特罗的代谢产物之一。 了解更多
  50. Guanabenz acetate

    Catalog No. A13635
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    2A-AR adrenergic 激动剂
    Guanabenz acetate是a2A-AR肾上腺素能激动剂和IGRS(咪唑啉I2结合位点)选择性配体。 了解更多

产品 1 到 50 共 67个

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