“jwh 250”的搜索结果

产品 1 到 50 共 107个

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  1. Cariprazine

    Catalog No. A21202
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    D3 receptor and D2 receptor partial agonist
    Cariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). 了解更多
  2. Taranabant ((1R,2R)stereoisomer)

    Catalog No. A21705
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    CB1 receptor inverse agonist
    Taranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist. 了解更多
  3. (1R,2R)-2-PCCA(hydrochloride)

    Catalog No. A21655
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    GPR88 receptor agonist
    (1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay. 了解更多
  4. Tonapofylline

    Catalog No. A21328
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    adenosine A1 receptor antagonist
    Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure. 了解更多
  5. Pavinetant

    Catalog No. A21174
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    NK3R antagonist
    Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist. 了解更多
  6. AMG 487

    Catalog No. A21162
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    CXCR3 antagonist
    AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. 了解更多
  7. LY2812223

    Catalog No. A21100
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    mGlu2 receptor agonist
    LY2812223 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively). 了解更多
  8. Lesopitron dihydrochloride

    Catalog No. A12950
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    5-HT1A receptor agonist
    Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes. 了解更多
  9. Zamicastat

    Catalog No. A13672
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    dopamine β-hydroxylase (DBH) inhibitor
    Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor that could cross the blood-brain barrier (BBB) and cause central as well as peripheral effects. 了解更多
  10. GNE-049

    Catalog No. A20206
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    CBP inhibitor
    GNE-049 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively. 了解更多
  11. Tasimelteon

    Catalog No. A17351
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    MT1 and MT2 receptor agonist
    Tasimelteon is a melatonin MT1 and MT2 receptor agonist. 了解更多
  12. Albiglutide

    Catalog No. A16823
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    GLP-1 激动剂
    Albiglutide是一种胰高血糖素样肽1激动剂(GLP-1激动剂)。 了解更多
  13. LY2979165

    Catalog No. A11487
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    mGlu2 激动剂
    LY2979165是mglu2激动剂。 了解更多
  14. Pardoprunox HCl (SLV-308)

    Catalog No. A11538
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    Pardoprunox HCl (SLV-308)是一种抗帕金森病药物,是多巴胺受体D2、D3和5-HT1A激动剂,用于治疗帕金森病。 了解更多
  15. CBiPES HCl

    Catalog No. A15811
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    mGlu2 receptor modulator
    CBiPES HCl是mGluR-2的选择性正变构调节剂,IC50值为98.2 nM。 了解更多
  16. UNBS5162

    Catalog No. A15439
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    CXCL chemokines 拮抗剂
    UNBS5162是一种新型萘二甲酰亚胺,可降低实验性前列腺癌中CXCL趋化因子的表达。9种癌细胞系的平均抗增殖活性IC50值为17.9 uM;UNBS3157的水解产物。 了解更多
  17. SB271046

    Catalog No. A15438
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    5-HT Receptor 拮抗剂
    SB271046 是一种有效的,选择性的5-HT6受体拮抗剂,pKi为8.9,与其他5-HT受体亚型相比,选择性高200倍。 了解更多
  18. OPC21268

    Catalog No. A15784
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    vasopressin V1 拮抗剂
    OPC21268是一种非肽AVP受体V(Vasopressin Receptor)拮抗剂,对V1受体的选择性是V2受体的1000倍。 了解更多
  19. ST-836 hydrochloride

    Catalog No. A15249
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    ST-836 hydrochloride是多巴胺受体配体;反帕金森氏剂。 了解更多
  20. PF-543 Citrate

    Catalog No. A15210
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    SphK1 抑制剂
    PF-543 Citrate是一种新型的SphK1细胞渗透抑制剂,K(i)为3.6 nM,PF-543具有鞘氨醇竞争性,对SphK1的选择性是SphK2同种型的100倍以上。 了解更多
  21. Ebrotidine

    Catalog No. A15075
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    H2-receptor 拮抗剂
    Ebrotidine是一种竞争性的H2受体拮抗剂(Ki = 127.5 nM),具有有效的抗分泌活性和胃保护作用。 了解更多
  22. SR 59230A HCl

    Catalog No. A13430
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    Adrenoceptors 拮抗剂
    SR 59230A HCl是3β-肾上腺素受体拮抗剂。 了解更多
  23. S-(-)-Atenolol

    Catalog No. A13427
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    Adrenoceptors 拮抗剂
    S-(-)-Atenolol是阿替洛尔的活性对映体,阿替洛尔是心脏选择性β肾上腺素能阻滞剂。 了解更多
  24. JP 1302 2HCl

    Catalog No. A13412
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    α2C 拮抗剂
    JP 1302 2HCl是一种强效和选择性α2C拮抗剂。 了解更多
  25. HEAT hydrochloride (BE 2254)

    Catalog No. A13408
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    Adrenergic α1 Receptor 拮抗剂
    HEAT hydrochloride (BE 2254)是一种选择性很强的α1-肾上腺素受体拮抗剂,是3-[125I]-衍生物的前体。肾上腺素受体或肾上腺素能受体是参与多种交感神经系统过程的G蛋白偶联受体。 了解更多
  26. A 943931 2HCl

    Catalog No. A13442
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    Histamine H4 receptor 拮抗剂
    943931 2HCl是一种有效的选择性组胺H4受体拮抗剂(人和大鼠受体的pKi值分别为7.15和8.12)。 了解更多
  27. S 32212 HCl

    Catalog No. A13501
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    5-HT2C 激动剂
    S 32212 HCl是5-HT2C受体的反向激动剂(人5-HT2C INI受体的pKi = 8.18)。 了解更多
  28. SB 258585 HCl

    Catalog No. A14026
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    5-HT6 serotonin receptor 拮抗剂
    SB 258585 hydrochloride是一种选择性和有效的SR-6拮抗剂。该化合物显示出比其他5-羟色胺受体亚型高160倍的选择性。 了解更多
  29. Ibotenic Acid

    Catalog No. A14006
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    NMDA& mGlu receptor 激动剂
    Ibotenic Acid是最初从鹅膏菌属物种中分离出来的一种神经兴奋性氨基酸,它起着NMDA和代谢型谷氨酸受体激动剂的作用。 了解更多
  30. KU14R

    Catalog No. A13987
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    I3 receptor 拮抗剂
    KU14R是胰腺β细胞非典型咪唑啉结合位点(可能的I3受体)的拮抗剂。KU14R也已显示出选择性阻断依法氧烷诱导的胰岛素分泌。 了解更多
  31. Linaclotide

    Catalog No. A13834
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    Guanylate cyclase C 激动剂
    Linaclotide是鸟苷酸环化酶2C的肽激动剂。 了解更多
  32. IRL-2500

    Catalog No. A13638
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    ETBR 拮抗剂
    IRL-2500是一种有效的选择性ETBR拮抗剂。它显示了对ETB受体的一些选择性(对于ETB和ETA受体,IC50值分别为1.3和94 nM)。 了解更多
  33. CYM 5442 HCl

    Catalog No. A13637
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    EDG-1 (S1P1) 激动剂
    CYM 5442 HCl是一种有效的体外选择性EDG-1(S1P1)激动剂(EC50 = 1.35 nM)。 了解更多
  34. Immethridine hydrobromide

    Catalog No. A13641
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    histamine H3 receptor 激动剂
    Immethridine hydrobromide是一种强而高选择性的组胺H3受体激动剂(pEC50 = 9.74),其选择性是H4受体的300倍(pKi值分别为9.07和6.61)。 了解更多
  35. CYN-154806

    Catalog No. A13714
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    somatostatin receptor 2 拮抗剂
    CYN-154806是一种有效的选择性生长抑素受体2(sst2)拮抗剂。 了解更多
  36. Atrasentan

    Catalog No. A13779
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    ETA 拮抗剂
    Atrasentan是一种实验药物,正在研究中,用于治疗各种类型的癌症,包括非小细胞肺癌。它是对A型亚型(ETA)有选择性的内皮素受体拮抗剂,对ETA的IC50为0.0551 nM。 了解更多
  37. A-841720

    Catalog No. A13854
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    mGluR-1 拮抗剂
    841720是一种有效的非竞争性mGluR-1拮抗剂,相对于mGluR-5具有34倍的选择性(IC50值分别为10和342 nM)。 了解更多
  38. AM095

    Catalog No. A13981
    LPA1 receptor 拮抗剂
    AM095是一种有效的LPA1受体拮抗剂,因为它抑制GTPβS与过量表达重组人或小鼠LPA1的中国仓鼠卵巢(CHO)细胞膜结合,IC50值分别为0.98和0.73μM,并且没有LPA1激动作用。 了解更多
  39. SB225002

    Catalog No. A14209
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    CXCR2 拮抗剂
    SB225002是一种有效的选择性CXCR2拮抗剂,IC50为22 nM,可抑制白介素IL-8与CXCR2的结合,选择性是其他测试的7-TMR的150倍以上。 了解更多
  40. SB 399885 HCl

    Catalog No. A14102
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    5-HT6 拮抗剂
    SB 399885 hydrochloride是一种有效的,脑渗透剂和口服活性的SR-6拮抗剂。它对SR-6的选择性比其他血清素受体高200倍(对于人类重组,天然大鼠和天然人类SR-6受体,pKi值分别为9.11、8.81和9.02)。 了解更多
  41. Almorexant

    Catalog No. A12503
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    OX 拮抗剂
    Almorexant (ACT078573)是一种有效的竞争性双重食欲素1受体(OX1)/orexin 2受体(OX2)拮抗剂,对于OX1和OX2的Ki值分别为1.3和0.17 nM。 了解更多
  42. AM251

    Catalog No. A12914
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    CB1 receptor 拮抗剂
    AM251是有效的CB1受体拮抗剂(IC50 = 8 nM,Ki = 7.49 nM),其选择性是CB2受体的306倍。 了解更多
  43. S1RA (E-52862)

    Catalog No. A12504
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    sigma-1 receptor 拮抗剂
    S1RA是一种选择性sigma-1受体拮抗剂,据报道其结合亲和力为Ki = 17.0±7.0 nM,对sigma-2受体具有选择性,并且对其他170种受体,酶,转运蛋白和离子通道具有选择性。 了解更多
  44. Reversine

    Catalog No. A13250
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    human A3 adenosine receptor 拮抗剂 /Aurora 抑制剂
    Reversine是一种有效的人A3腺苷受体拮抗剂,Ki为0.66μM,是一种泛光A/B/C激酶抑制剂,IC50分别为12 nM/13 nM/20 nM。也用于干细胞去分化。 了解更多
  45. BMS-927711

    Catalog No. A13102
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    CGRP receptor 拮抗剂
    BMS-927711是一种有效的,选择性的,竞争性的人降钙素基因相关肽(CGRP)受体拮抗剂,已显示出体内功效,而没有血管收缩作用。 了解更多
  46. 5-HT1A receptor 拮抗剂
    NAD 299 hydrochloride (Robalzotan)是一种选择性的,高亲和力的5-HT1A受体拮抗剂(体外Ki = 0.6 nM)。 了解更多
  47. lorcaserin hydrochloride (APD-356)

    Catalog No. A12598
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    serotonin 2C receptor 激动剂
    lorcaserin hydrochloride (APD-356)是血清素2C受体激动剂,可指示与减少热量饮食和增加体育锻炼以减轻慢性体重成人管理。 了解更多
  48. ICI 118,551 hydrochloride

    Catalog No. A13225
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    β2 adrenergic 拮抗剂
    ICI 118,551 hydrochloride是选择性的β2 adrenergic receptor 拮抗剂,结合 β2,β1 和 β3 肾上腺素能受体的Ki 值分别为 0.7,49.5 和 611 nM。 了解更多
  49. YC-1 (Lificiguat)

    Catalog No. A12402
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    sGC activator
    YC-1 (Lificiguat)是可溶性胍基环化酶(sGC)的直接活化剂,独立于一氧化氮。 了解更多
  50. Arformoterol tartrate

    Catalog No. A12795
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    beta2-adrenergic 激动剂
    Arformoterol tartrate是β2-肾上腺素能激动剂。 了解更多

产品 1 到 50 共 107个

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