“263”的搜索结果

产品 1 到 50 共 131个

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  1. ABT-263 (Navitoclax)

    Catalog No. A10022
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    Bcl-2 抑制剂
    ABT-263 (Navitoclax)是一种有效的Bcl-2家族抑制剂 (Bcl-2,Bcl-xL和Bcl-w的Ki <1 nmol/L)。ABT-263对Bcl- xL,Bcl-2和Bcl-w,( Ki≤1nmol/ L) 维持高亲和力,但与Mcl-1和A1的结合更弱。 了解更多
  2. TH-263

    Catalog No. A22197
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    inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251
    TH-263 is an inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251. 了解更多
  3. Centrinone

    Catalog No. A20858
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    PLK4 inhibitor
    Centrinone (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM. 了解更多
  4. Azelaprag

    Catalog No. A20257
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    Azelaprag (Example 263.0) is an apelin receptor agonist drug candidate. 了解更多
  5. Philanthotoxin 74 dihydrochloride

    Catalog No. A21739
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    AMPAR antagonist
    Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. 了解更多
  6. Clobenpropit dihydrobromide

    Catalog No. A22263
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    histamine H3R antagonist/inverse agonist
    Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC50 of 8.07 for histamine H3LR. 了解更多
  7. DCLK1-IN-1

    Catalog No. A22319
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    chemical probe
    DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. 了解更多
  8. PD184161

    Catalog No. A22601
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    MEK inhibitor
    PD184161 is an orally-active MEK inhibitor. 了解更多
  9. YM 298198 Hydrochloride

    Catalog No. A22630
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    mGlu1 receptorsant agonist
    YM 298198 Hydrochloride is a non-competitive antagonist with high affinity and selectivity for mGlu1 receptors (Ki = 19 nM). 了解更多
  10. NPS2390

    Catalog No. A22631
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    group I mGlu antagonist
    NPS2390 is a group I mGlu antagonist. It displays noncompetitive antagonist activity at both mGlu1 and mGlu5 receptors. NPS2390 is thought to act on a site separate from the glutamate binding pocket. 了解更多
  11. SJM-3

    Catalog No. A22632
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    positive allosteric modulator of different isoforms of the GABAA receptor
    SJM-3 is a positive allosteric modulator of different isoforms of the GABAA receptor. SJM-3 binds at the high-affinity benzodiazepine binding site at the α+/γ- subunit interface. 了解更多
  12. Galnon

    Catalog No. A22633
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    agonist at the galanin receptors GALR
    Galnon is a selective, non-peptide agonist at the galanin receptors GALR. 了解更多
  13. Gabazine free base

    Catalog No. A22634
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    GABA receptor antagonist
    Gabazine free base is a specific GABA receptor antagonist. Does not affect GABA-transaminase or glutamate-decarboxylase activitites. 了解更多
  14. Tracazolate

    Catalog No. A22635
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    pyrazolopyridine anxiolytic
    Tracazolate is a pyrazolopyridine anxiolytic known to interact with gamma-aminobutyric acid (GABA)(A) receptors, adenosine receptors, and phosphodiesterases. 了解更多
  15. Tioxazafen

    Catalog No. A22636
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    broad-spectrum seed treatment nematicide
    Tioxazafen is a disubstituted oxadiazole and a broad-spectrum seed treatment nematicide. Tioxazafen is designed to provide consistent broad-spectrum control of nematodes in corn, soy, and cotton. 了解更多
  16. Talinolol

    Catalog No. A22637
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    Talinolol is a beta(1)-adrenergic receptor antagonist and a probe drug for P-glycoprotein (P-gp) activity in humans.
    Talinolol is a beta(1)-adrenergic receptor antagonist and a probe drug for P-glycoprotein (P-gp) activity in humans. 了解更多
  17. Betahistine EP Impurity C

    Catalog No. A22638
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    histamine H1 receptor agonist and H3 receptor antagonist
    Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA). 了解更多
  18. Methyl 13-cis-4-Oxoretinoate

    Catalog No. A22639
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    bioactive chemical
    Methyl 13-cis-4-Oxoretinoate is a bioactive chemical. 了解更多
  19. L-159282

    Catalog No. A20703
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    nonpeptide angiotensin II receptor antagonist
    L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity. 了解更多
  20. sulfo-SPDB-DM4

    Catalog No. A20566
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    sulfo-SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker. 了解更多
  21. Methyl-3β-hydroxycholenate

    Catalog No. A20344
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    ROR gamma modulator
    Methyl-3β-hydroxycholenate is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2. 了解更多
  22. Sigma-2 receptor antagonist 1

    Catalog No. A20310
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    sigma-2 (??-2) receptor antagonist
    Sigma-2 receptor antagonist 1 is a sigma-2 (??-2) receptor antagonist. 了解更多
  23. Boc-C1-PEG2-C4-Cl

    Catalog No. A20263
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    Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand. 了解更多
  24. Dianicline dihydrochloride

    Catalog No. A19775
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    α4β2 nicotinic acetylcholine receptor partial agonist
    Dianicline dihydrochloride is a α4β2 nicotinic acetylcholine receptor partial agonist, a class of drugs that includes varenicline and cytisine for smoking cessation. 了解更多
  25. EMDT oxalate

    Catalog No. A19667
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    5-HT6 agonist
    EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects. 了解更多
  26. AGL-2263

    Catalog No. A19525
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    insulin receptor (IR) blocker
    AGL-2263 is an insulin receptor (IR) blocker. 了解更多
  27. Kv3 modulator 1

    Catalog No. A19338
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    Kv3 voltage-gated potassium channel modulator
    Kv3 modulator 1 is a Kv3 voltage-gated potassium channel modulator extracted from patent WO2018020263A1, Compound X. Kv3 modulator 1 can be used to treat inflammatory pain. 了解更多
  28. BB-Cl-Amidine

    Catalog No. A19265
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    PAD inhibitor
    BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor. 了解更多
  29. PGS-IN-1

    Catalog No. A19263
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    PGS inhibitor
    PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM. 了解更多
  30. Delgocitinib

    Catalog No. A19234
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    JAK inhibitor
    Delgocitinib is a novel and specific JAK inhibitor with IC50s of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, respectively. 了解更多
  31. SPDB-DM4

    Catalog No. A21413
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    SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity. 了解更多
  32. MRT-83

    Catalog No. A21020
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    Smo antagonist
    MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. 了解更多
  33. HG-9-91-01

    Catalog No. A21004
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    SIK inhibitor
    HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. 了解更多
  34. CK-666

    Catalog No. A20973
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    Arp2/3 complex inhibitor
    CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation. 了解更多
  35. BTZ043

    Catalog No. A21263
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    DprE1 inhibitor
    BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively. 了解更多
  36. (1R,2S)-VU0155041

    Catalog No. A21933
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    partial mGluR4 agonist
    (1R,2S)-VU0155041, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM. 了解更多
  37. 7-Chlorokynurenic acid sodium salt

    Catalog No. A21879
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    NMDA receptor antagonist
    7-Chlorokynurenic acid sodium salt is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 了解更多
  38. D-3263

    Catalog No. A20935
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    TRPM8 agonist
    D-3263 is an agonist of transient receptor potential melastatin member 8 (TRPM8) with potential antineoplastic activity. 了解更多
  39. Galidesivir hydrochloride

    Catalog No. A20930
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    RdRp inhibitor
    Galidesivir hydrochloride (BCX 4430 hydrochloride) is a viral RNA-dependent RNA polymerase (RdRp) inhibitor; demonstrated broad-spectrum activity in multiple viruses and a favorable preliminary preclinical safety profile. 了解更多
  40. Tavilermide

    Catalog No. A20876
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    TrkA agonist
    Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic. 了解更多
  41. Sutezolid

    Catalog No. A12638
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    oxazolidinone antimicrobial
    Sutezolid (PNU-100480) is an oxazolidinone antimicrobial being developed for the treatment of tuberculosis. 了解更多
  42. 6-(γ,γ-Dimethylallylamino)purine

    Catalog No. A12636
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    6-(γ,γ-Dimethylallylamino)purine is a plant growth substance. 了解更多
  43. Propyl pyrazole triol

    Catalog No. A13329
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    ERα agonist
    Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERα) agonist. 了解更多
  44. Fluzinamide

    Catalog No. A12949
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    Fluzinamide is an effective antiepileptic. 了解更多
  45. Petesicatib

    Catalog No. A13394
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    cathepsin S inhibitor
    Petesicatib is a cathepsin S inhibitor, used in research of immune diseases. 了解更多
  46. Salermide

    Catalog No. A12263
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    Sirt1/Sirt2 inhibitor
    Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. 了解更多
  47. PF-06263276

    Catalog No. A12572
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    pan-JAK inhibitor
    PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively. 了解更多
  48. (S)-Leucic acid

    Catalog No. A12630
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    (S)-Leucic acid is an amino acid metabolite. 了解更多
  49. CNT2 inhibitor-1

    Catalog No. A12632
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    CNT2 Inhibitor
    CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2. 了解更多
  50. Cy3 NHS ester

    Catalog No. A12635
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    Cy3 NHS (Cyanine3 NHS ester) is a water-soluble and yellow emitting fluorescent dye for labeling amino-groups in biomolecules. Used to label soluble proteins, peptides, and oligonucleotides/DNA. 了解更多

产品 1 到 50 共 131个

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