“AZ 960”的搜索结果

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  1. TAK-960 hydrochloride

    Catalog No. A21703
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    PLK1 inhibitor
    TAK-960 hydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM at 10 μM ATP; TAK-960 hydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. 了解更多
  2. AZ-960

    Catalog No. A10104
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    JAK2抑制剂
    AZ-960是一种有效的,选择性的和ATP竞争性的JAK2抑制剂,在体外抑制JAK2激酶的Ki为0.45 nM,并诱导成年T细胞白血病(ATL)细胞的生长停滞和凋亡 了解更多
  3. TAK-960

    Catalog No. A11146
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    PLK1 抑制剂?
    TAK-960是新型的,口服可用的polo样激酶1选择性抑制剂,具有广谱的临床前抗肿瘤活性。 了解更多
  4. Tubastatin A (trifluoroacetate salt)

    Catalog No. A22427
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    HDAC6 inhibitor
    Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. 了解更多
  5. 2'-Deoxyuridine 5'-monophosphate disodium salt

    Catalog No. A22446
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    Antibacterial agent
    2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth. 了解更多
  6. KDM5A-IN-1

    Catalog No. A20436
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    KDM5 inhibitor
    KDM5A-IN-1 is a potent, orally bioavailable pan-histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 45 nM, 56 nM and 55 nM for KDM5A, KDM5B and KDM5C, respectively, and with an EC50 value of 960 nM for PC9 H3K4Me3. 了解更多
  7. Clinafloxacin

    Catalog No. A16458
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    DNA gyrase and topoisomerase IV 抑制剂
    Clinafloxacin是一种氟喹诺酮,可双重抑制肺炎链球菌中的DNA促旋酶和拓扑异构酶IV。 了解更多
  8. Sancycline

    Catalog No. A13393
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    Sancycline像其他四环素类药物一样,三环素通过可逆地结合到30S核糖体亚单位并通过阻断氨酰tRNA进入核糖体A位点来抑制蛋白质翻译。 了解更多
  9. CFTRinh-172

    Catalog No. A12897
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    CFTR 抑制剂
    CFTRinh-172是电压无关的选择性CFTR抑制剂。在2分钟内可逆地抑制CFTR短路电流的 Ki 值为300 nM。 了解更多
  10. ML167

    Catalog No. A14297
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    Clk4 抑制剂
    ML167是一种高度选择性的Cdc2样激酶4(Clk4)抑制剂。 了解更多
  11. PF-04620110

    Catalog No. A11526
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    DGAT1 抑制剂
    PF-04620110是一种有效、选择性的,有口服活性的甘油二酯酰基转移酶-1 (DGAT1) 抑制剂,IC50值为 19 nM。 了解更多
  12. SANT-1

    Catalog No. A13095
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    Sonic hedgehog 抑制剂
    SANT-1是有效的细胞渗透性Sonic刺猬(Shh)信号传导抑制剂;平滑活性的高亲和力拮抗剂(KD = 1.2 nM)。以20 nM的IC50抑制平滑的激动剂作用(在Shh-LIGHT2细胞中)。 了解更多
  13. Lincomycin hydrochloride (U-10149A)

    Catalog No. A10532
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    Lincomycin hydrochloride是Lincomycin的一水盐,是从林肯链霉菌中分离的林肯酰胺抗生素,据报道其抑制细菌蛋白质合成并依赖于浓度。 了解更多
  14. Pifithrin-alpha

    Catalog No. A12451
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    p53 抑制剂
    Pifithrin-alpha是p53介导的细胞凋亡和p53依赖性基因转录(如细胞周期蛋白G,p21/waf1和mdm2表达)的可逆抑制剂。 了解更多
  15. JNJ 1661010

    Catalog No. A12420
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    FAAH 抑制剂
    JNJ 1661010是一种选择性和可逆的脂肪酸酰胺水解酶(FAAH)抑制剂(IC50 = 12nM)。 了解更多
  16. Diethylstilbestrol

    Catalog No. A10309
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    Diethylstilbestrol是一种合成的非甾体雌激素,于1938年首次合成。它也被分类为内分泌干扰物。 了解更多
  17. Deferasirox

    Catalog No. A10293
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    Iron chelator
    Deferasirox是一种铁螯合剂,也是细胞色素P450 3A4诱导剂,细胞色素P450 2C8抑制剂和细胞色素P450 1A2抑制剂。 了解更多
  18. Naringin (Naringoside)

    Catalog No. A10626
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    Naringin (Naringoside)是一种黄酮苷,是葡萄柚中的主要的类黄酮,具有柚子汁的苦味。具有抗氧化,降血脂,抗肿瘤活性,并且对cytochrome P450有抑制作用。 了解更多
  19. PF 3716556

    Catalog No. A11408
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    ATPase 拮抗剂
    PF 3716556是H+,K+-ATPase酶抑制剂(在人类重组离子渗漏试验中PIC50 = 6)。 了解更多
  20. AS-252424

    Catalog No. A11099
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    PI3K 抑制剂
    AS-252424是有效的PI3K抑制剂,对γ亚型具有选择性。它抑制人重组PI3Kγ,α,β和δ,IC50值分别为30、940、20,000和20,000 nM。 了解更多
  21. 6-Diazo-5-oxo-L-nor-Leucine

    Catalog No. A20846
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    6-Diazo-5-oxo-L-norleucine 是一种从链霉菌中分离出来的抗生素,一种 glutaminase 的拮抗剂对cKGA(肾脏型谷氨酰胺酶)的IC50值约为1 mM。 了解更多
  22. Pertussis Toxin

    Catalog No. A19356
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    protein-based AB5-type exotoxin
    Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. 了解更多
  23. Cinnamylamine

    Catalog No. A20835
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    Cinnamylamine can be used for the preparation of Tranylcypromine, a drug that acts as a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO), and is used as an antidepressant and anxiolytic agent. 了解更多
  24. H-β-Ala-AMC TFA

    Catalog No. A22059
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    substrate for aminopeptidase
    H-β-Ala-AMC TFA is a substrate for aminopeptidase. 了解更多
  25. HS-243

    Catalog No. A22071
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    transforming growth factor-?beta kinase inhibitor
    HS-243 is an inhibitor of transforming growth factor-?beta kinase. HS-243 can be used in treatment of cancer, malaria, inflammatory and other TAK1-?mediated diseases. 了解更多
  26. PF9601N

    Catalog No. A22075
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    monoamine oxidase B inhibitor
    PF9601N is a selective and potent monoamine oxidase B inhibitor that exhibit anti-Parkinsonian effects in several models of PD. 了解更多
  27. BMS453

    Catalog No. A22082
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    RARβ agonist
    BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. 了解更多
  28. ML299

    Catalog No. A22094
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    PLD1/PLD2 dual inhibitor
    ML299 (VU0463568) is a dual inhibitor of PLD1 and PLD2 with IC50 of 6 nM and 20 nM, respectively. 了解更多
  29. BPU-11

    Catalog No. A22101
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    HCN4 CLP ligand
    BPU-11 is a HCN4 CLP ligand. It acts by modulating channel function and completely abolishing the cAMP-induced shift in V1/2. 了解更多
  30. AEM1

    Catalog No. A22108
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    inhibitor of deregulated NRF2 transcriptional activity
    AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. 了解更多
  31. Creatine riboside

    Catalog No. A22112
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    urinary metabolite
    Creatine riboside is a urinary metabolite and is a diagnostic and prognostic biomarker of lung cancer. 了解更多
  32. BGC201531

    Catalog No. A22130
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    EP4 antagonist
    BGC201531, also known as GTPL3380 and AP-1531, is a EP4 antagonist for the treatment of acute migraine. 了解更多
  33. RGW 611

    Catalog No. A22135
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    anti-infective agent
    RGW 611, a morpholine derivative, is an impurity of Nimorazole, which is an anti-infective agent against anaerobic bacteria and protozoa. 了解更多
  34. Soporidine

    Catalog No. A22145
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    strigolactone (SL) antagonist
    Soporidine is a strigolactone (SL) antagonist and inhibitor of germination in their biological assays. It binds AtHTL and specifically interferes with SL signaling. 了解更多
  35. Remimazolam besylate

    Catalog No. A22198
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    ultra short-acting benzodiazepine
    Remimazolam besylate is an ultra short-acting benzodiazepine used in the induction and maintenance of sedation during short (<30 minute) procedures. 了解更多
  36. 5-HT3 antagonist-4i

    Catalog No. A22265
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    5-HT3 receptor antagonist
    5-HT3 antagonist-4i is a 5-HT3 receptor antagonist which modulates the serotonergic system. 了解更多
  37. RGD peptide (GRGDNP)

    Catalog No. A22271
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    integrin-ligand interactions inhibitor
    RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and plays an important role in cell adhesion, migration, growth, and differentiation. 了解更多
  38. AUNP-12

    Catalog No. A22274
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    peptide antagonist
    AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. 了解更多
  39. Ellagic acid (hydrate)

    Catalog No. A22282
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    ATP-competitive CK2 inhibitor
    Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. 了解更多
  40. HA-100 dihydrochloride

    Catalog No. A22289
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    PKs inhibitor
    HA-100 is an isoquinoline compound with an added piperazinylsulfonyl group that acts as an inhibitor of protein kinases (PKs), including PKA, PKC, and PKG (IC50s = 8, 12, and 4 ?M, respectively). 了解更多
  41. Alflutinib

    Catalog No. A22316
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    EGFR inhibitor
    Alflutinib is an EGFR inhibitor that targets both EGFR activating mutations and T790M, thus leading to tumor growth inhibition. 了解更多
  42. BO-264

    Catalog No. A22318
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    TACC3 inhibitor
    BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. 了解更多
  43. AG1557

    Catalog No. A22324
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    EGFR inhibitor
    AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194. 了解更多
  44. Ehp inhibitor 2

    Catalog No. A22325
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    Eph family tyrosine kinase inhibitor
    Ehp inhibitor 2 is a Eph family tyrosine kinase inhibitor. 了解更多
  45. MAZ51

    Catalog No. A22331
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    VEGFR-3 (Flt-4) tyrosine kinase inhibitor
    MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. 了解更多
  46. 7-Nitroindazole

    Catalog No. A22342
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    neuronal nitric oxide synthase inhibitor
    7-Nitroindazole, a heterocyclic compound, acts as a selective inhibitor for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS. 了解更多
  47. JNJ-38158471

    Catalog No. A22345
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    VEGFR-2 inhibitor
    JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively. 了解更多
  48. 3-Deazaadenosine hydrochloride

    Catalog No. A22347
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    inhibitor of S-adenosylhomocysteine hydrolase
    3-Deazaadenosine (hydrochloride) is an inhibitor of S-adenosylhomocysteine hydrolase, with a Ki of 3.9 ?M; 3-Deazaadenosine has anti-inflammatory, anti-proliferative and anti-HIV activity. 了解更多
  49. Pyridoxine

    Catalog No. A22350
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    antioxidant agent
    Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. 了解更多
  50. Solamargine

    Catalog No. A22357
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    anticancer agent
    Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. 了解更多

产品 1 到 50 共 1994个

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