“EGFR”的搜索结果

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  1. Mutated EGFR-IN-2

    Catalog No. A18565
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    EGFR 抑制剂
    Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=??1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity. 了解更多
  2. Mutated EGFR-IN-1

    Catalog No. A20555
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    EGFR inhibitor
    Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. 了解更多
  3. CHMFL-EGFR-202

    Catalog No. A12524
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    EGFR inhibitor
    CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. 了解更多
  4. EGFR-IN-7

    Catalog No. A18562
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    EGFR 抑制剂
    EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity. 了解更多
  5. EGFR-IN-5

    Catalog No. A20082
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    EGFR inhibitor
    EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively. 了解更多
  6. Mutant EGFR inhibitor

    Catalog No. A21144
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    EGFR inhibitor
    Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M. 了解更多
  7. EGFR-IN-3

    Catalog No. A15847
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    EGFR inhibitor
    EGFR-IN-3 is an epidermal growth factor receptor (EGFR) inhibitor. 了解更多
  8. Icotinib

    Catalog No. A13825
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    EGFR 抑制剂
    Icotinib是一种有效的特异性EGFR抑制剂,IC50为5 nM,包括EGFR,EGFR(L858R),EGFR(L861Q),EGFR(T790M)和EGFR(T790M,L858R)。 了解更多
  9. Icotinib Hydrochloride

    Catalog No. A13718
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    EGFR 抑制剂
    Icotinib hydrochloride是一种有效的特异性表皮生长因子受体(EGFR)酪氨酸激酶抑制剂(TKI),IC(50)为5 nM,包括EGFR(L858R),EGFR(L861Q),EGFR(T790M)和EGFR的突变体(T790M,L858R)。 了解更多
  10. EGFR-IN-2

    Catalog No. A12628
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    EGFR inhibitor
    EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor. 了解更多
  11. EGFR Inhibitor

    Catalog No. A13673
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    EGFR 抑制剂
    EGFR inhibitor是一种可透过细胞的4,6-二取代嘧啶化合物,可选择性抑制EGFR激酶,在体外的IC50值为21 nM,可阻断细胞中的受体自身磷酸化。 了解更多
  12. AZD-9291 (Osimertinib)

    Catalog No. A13681
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    EGFR 抑制剂
    AZD-9291 (Osimertinib)是第三代EGFR抑制剂,在临床前研究中显示出希望,并为已对现有EGFR抑制剂产生耐药性的晚期肺癌患者提供了希望。 了解更多
  13. CO-1686 (Rociletinib, AVL-301)

    Catalog No. A13028
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    EGFR 抑制剂
    CO-1686是一种新型的口服靶向共价(不可逆)抑制剂,可抑制表皮生长因子受体(EGFR)的致癌突变形式,目前正在研究用于治疗非小细胞肺癌(NSCLC)。 了解更多
  14. AZ5104

    Catalog No. A15516
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    EGFR 抑制剂
    AZD-9291的去甲基代谢产物AZ5104是一种有效的EGFR抑制剂,对于EGFR(L858R/T790M),EGFR(L858R),EGFR(L861Q)和EGFR,IC50 <1 nM,6 nM,1 nM和25 nM EGFR(野生型)。 了解更多
  15. Naquotinib mesylate

    Catalog No. A20762
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    EGFR inhibitor
    Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor; with IC50s of 8-33 nM toward EGFR mutants and 230 nM for EGFR. 了解更多
  16. NSC 228155

    Catalog No. A16638
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    EGFR activator
    NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR. 了解更多
  17. EGFR Human Sf9

    Catalog No. AP3988
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    Epidermal Growth Factor Receptor Sf9 Human Recombinant 了解更多
  18. EGFR Human Sf9, Active

    Catalog No. AP3987
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    Epidermal Growth Factor Receptor Human Recombinant Sf9 了解更多
  19. EGFR Human, CHO

    Catalog No. AP3986
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    Epidermal Growth Factor Receptor, CHO Human Recombinant 了解更多
  20. Recombinant EGFR Antibody

    Catalog No. AP2765
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    Recombinant Anti Human Epidermal Growth Factor Receptor 了解更多
  21. EGFR Antibody

    Catalog No. AP2652
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    Epidermal Growth Factor Receptor, Mouse Anti Human 了解更多
  22. ASP8273 (Naquotinib)

    Catalog No. A14408
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    irreversible EGFR 抑制剂
    ASP8273 (Naquotinib)是不可逆的,第三代,选择性突变的表皮生长因子受体(EGFR)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  23. CNX-2006

    Catalog No. A13755
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    EGFR 抑制剂
    CNX-2006是一种有效的突变体选择性EGFR抑制剂,在具有激活性EGFR突变的细胞以及具有T790M突变的细胞中具有出色的体外活性。CNX-2006是CO-1686的原型,目前正在I期临床试验中,用于治疗EGFR突变型肺癌。 了解更多
  24. BI-4020

    Catalog No. A22046
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    EGFR inhibitor
    BI-4020 is an orally active, non-covalent EGFR inhibitor with IC50 of 0.6 nM and 0.2 nM for EGFR. 了解更多
  25. BDTX-189

    Catalog No. A22306
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    Anticancer agent
    BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity. 了解更多
  26. Alflutinib

    Catalog No. A22316
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    EGFR inhibitor
    Alflutinib is an EGFR inhibitor that targets both EGFR activating mutations and T790M, thus leading to tumor growth inhibition. 了解更多
  27. Mobocertinib

    Catalog No. A22334
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    inhibitor of EGFR and HER2 oncogenic mutants
    Mobocertinib (TAK-788) is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity. 了解更多
  28. Almonertinib

    Catalog No. A22232
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    EGFR inhibitor
    Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. 了解更多
  29. Mobocertinib succinate

    Catalog No. A22240
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    EGFR/HER2 oncogenic mutants inhibitor
    Mobocertinib succinate (TAK-788 succinate) is a potent and orally active inhibitor of EGFR and HER2 oncogenic mutants, including exon 20 insertions, with selectivity over WT EGFR. Antitumor activity. 了解更多
  30. Lifirafenib

    Catalog No. A20988
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    Raf/EGFR inhibitor
    Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. 了解更多
  31. Nazartinib mesylate

    Catalog No. A21741
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    covalent mutant-selective EGFR inhibitor
    Nazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min?1 on EGFR(L858R/790M) mutant, respectively. 了解更多
  32. HS-10296 hydrochloride

    Catalog No. A21661
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    EGFR/T790M inhibitor
    HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. 了解更多
  33. Canertinib dihydrochloride

    Catalog No. A11344
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    EGFR inhibitor
    Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. 了解更多
  34. EGF816 (Nazartinib)

    Catalog No. A14416
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    EGFR T790M 抑制剂
    EGF816 (Nazartinib)是新型的突变选择性EGFR共价抑制剂。克服了NSCLC中T790M介导的耐药性。 了解更多
  35. AZD3759

    Catalog No. A15551
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    EGFR 抑制剂
    AZD3759是表皮生长因子受体(EGFR)的口服抑制剂。它结合并抑制EGFR以及某些突变形式的EGFR的活性。 了解更多
  36. Gefitinib hydrochloride

    Catalog No. A15093
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    EGFR 抑制剂
    Gefitinib hydrochloride是一种EGFR抑制剂,可通过靶细胞中的表皮生长因子受体(EGFR)中断信号传导。因此,它仅在EGFR突变和过度活跃的癌症中有效。 了解更多
  37. Afatinib dimaleate

    Catalog No. A14985
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    EGFR 抑制剂
    Afatinib dimaleate是一种不可逆的EGFR/HER2抑制剂,对于HER2的体外药效IC50为14 nM。 了解更多
  38. PD-089828

    Catalog No. A22103
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    ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR
    PD089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-β and EGFR with IC50 of 0.15 ?M, 1.76 ?M, and 5.47 ?M, respectively. 了解更多
  39. (Rac)-JBJ-04-125-02

    Catalog No. A22141
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    EGFR inhibitor
    (Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a potent, mutant-selective, allosteric and orally active EGFR inhibitor with an IC50 of 0.26 nM for EGFRL858R/T790M. 了解更多
  40. AG1557

    Catalog No. A22324
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    EGFR inhibitor
    AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194. 了解更多
  41. Theliatinib

    Catalog No. A22215
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    EGFR inhibitor
    Theliatinib (HMPL-309) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. 了解更多
  42. AG-1478 hydrochloride

    Catalog No. A22262
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    EGFR tyrosine kinase inhibitor
    AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. 了解更多
  43. ZD-4190

    Catalog No. A22369
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    VEGFR2 and EGFR signalling inhibitor
    ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer. 了解更多
  44. Cyasterone

    Catalog No. A22387
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    EGFR inhibitor
    Cyasterone, a natural EGFR inhibitor, mainly isolated from Ajuga decumbens Thunb (Labiatae). 了解更多
  45. Norcantharidin

    Catalog No. A22396
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    dual inhibitor for c-Met and EGFR
    Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. 了解更多
  46. NRC-2694

    Catalog No. A20643
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    EGFR antagonist
    NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties. 了解更多
  47. PF-06459988

    Catalog No. A20608
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    T790M-Containing EGFR Mutants inhibitor
    PF-06459988 is an irreversible inhibitor of T790M-Containing EGFR Mutants. 了解更多
  48. TAS6417

    Catalog No. A19541
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    EGFR inhibitor
    TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM. 了解更多
  49. Pyrotinib

    Catalog No. A19423
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    EGFR/HER2 dual inhibitor
    Pyrotinib (SHR-1258) is a potent and selective EGFR/HER2 dual inhibitor with IC50s of 13 and 38 nM, respectively. 了解更多
  50. Osimertinib dimesylate

    Catalog No. A18243
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    EGFR inhibitor
    Osimertinib dimesylate (AZD-9291 dimesylate) is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively. 了解更多

产品 1 到 50 共 259个

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