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  1. Abiraterone metabolite 1

    Catalog No. A16992
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    Abiraterone metabolite 1是阿比特龙的5β还原代谢物。 阿比特龙是一种甾体类药物,可抑制CYP17A1,阻断雄激素合成,延长前列腺癌的存活率。 了解更多
  2. Vecabrutinib

    Catalog No. A17189
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    BTK inhibitor
    Vecabrutinib是一种有效的,非共价的,可逆的BTK抑制剂,可抑制通过BCR途径的信号传导。 了解更多
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    YHO-13177

    Catalog No. A17127
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    BCRP/ABCG2 inhibitor
    YHO-13177是一种有效的特异性乳腺癌耐药蛋白抑制剂(BCRP / ABCG2)。 了解更多
  3. Cgp 52432

    Catalog No. A17140
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    GABA-A receptor antagonist
    Cgp 52432是GABA-A受体拮抗剂。 了解更多
  4. CA-4948

    Catalog No. A17005
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    IRAK4 inhibitor
    CA-4948是一种有效的口服活性白细胞介素-1受体相关激酶4(IRAK4)抑制剂。 与GBC-DLBCL和ABC / GCB DLBCL PDX模型相比,CA-4948在测试的五种ABC-DLBCL PDX模型中的四种中表现出最大功效。 了解更多
  5. Sabinene

    Catalog No. A17026
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    Sabinene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has antifungal and anti-inflammatory properties. 了解更多
  6. TM N1324

    Catalog No. A17038
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    GPR39 agonist
    TM N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39. 了解更多
  7. Androsterone

    Catalog No. A17043
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    Androsterone is a steroid hormone produced in the body from 5α-reduced metabolites of dehydroepiandrosterone. It is the major androgen excreted in urine as a metabolite of testosterone and is used as the international reference standard for androgenic activity. 了解更多
  8. NGP-555

    Catalog No. A17051
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    γ-Secretase Modulator
    NGP-555 is a gamma-secretase modulator with a selective mechanism to reduce Abeta 42 while raising shorter Abeta forms such as Abeta 37 and 38. 了解更多
  9. Nedisertib

    Catalog No. A17055
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    DNA-PK inhibitor
    Nedisertib, also known as M-3814, MSC2490484A, is an orally available inhibitor of DNA-dependent protein kinase (DNA-PK), with potential antineoplastic and chemo/radiosensitizing activities. 了解更多
  10. CY3

    Catalog No. A17058
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    CY3 is a fluorescent labeling reagent. 了解更多
  11. BAY-1436032

    Catalog No. A17059
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    mIDH1 inhibitor
    BAY-1436032 is a potent, selective and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). 了解更多
  12. AZD-5904

    Catalog No. A17062
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    MPO inhibitor
    AZD-5904 is a potent orally bioavailable MPO inhibitor. In preclinical studies, AZD-5904 inhibited the isolated MPO enzyme with an IC50 of 140 nM and was approximately equipotent in assays of rat and mouse MPO enzyme activity. 了解更多
  13. MK-3903

    Catalog No. A17063
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    AMPK activator
    MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 exhibited robust target engagement in mouse liver following oral dosing, leading to improved lipid metabolism and insulin sensitization in mice. 了解更多
  14. Anabasine

    Catalog No. A17067
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    insecticide
    Anabasine is a piperidine botanical insecticide. 了解更多
  15. ASTX-660

    Catalog No. A16996
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    XIAP inhibitor
    ASTX660 is an orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1), with potential antineoplastic and pro-apoptoticctivities. 1799328-86-1 (free base) 1799328-50-9 (HCl) 1799328-90-7 (mesylate) 1799328-88-3 (sulfate) 了解更多
  16. ELN484228

    Catalog No. A17071
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    ELN484228 is a cell-permeable alpha-Synuclein Blocker. 了解更多
  17. Pamiparib

    Catalog No. A17073
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    PARP inhibitor
    Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. CAS: 1446261-44-1 (free base) 2086689-94-1 (maleate) 2086689-93-0 (hydrate) 了解更多
  18. AZD7986

    Catalog No. A17095
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    DPPI inhibitor
    AZD7986, also known as INS 1007, is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing. 了解更多
  19. (-)-Securinine

    Catalog No. A17102
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    GABA receptor antagonist
    (-)-Securinine is an alkaloid originally isolated from S. suffructicosa. Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity. 了解更多
  20. Desformylflustrabromine HCl

    Catalog No. A17103
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    Desformylflustrabromine HCl is a positive allosteric modulator of α4β2 and also a muscle-type nAChR inhibitor. 了解更多
  21. Bamaluzole

    Catalog No. A17107
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    GABA receptor agonist
    Bamaluzole is a GABA receptor agonist. 了解更多
  22. Timegadine

    Catalog No. A17108
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    COX and lipo-oxygenase inhibitor
    Timegadine, a new antiinflammatory agent, is found to be a potent, competitive inhibitor of cyclo-oxygenase (COX) and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM for lipo-oxygenase both in the cytosol fraction of horse platelet homogenates, and in washed rabbit platelets. 了解更多
  23. JNJ-64619178

    Catalog No. A16861
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    Histone Methyltransferase inhibitor
    JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties. 了解更多
  24. PF-06873600

    Catalog No. A16875
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    CDK inhibitor
    PF-06873600 is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. 了解更多
  25. GOAT-IN-1

    Catalog No. A16879
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    Ghrelin O-acyltransferase (GOAT) inhibitor
    GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer's disease, Parkinson's disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors. 了解更多
  26. Galanin (1-30) (human)

    Catalog No. A16890
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    Endogenous galanin receptor agonist
    Galanin (1-30) (human) is an endogenous peptide with multiple endocrine, metabolic and behavioral effects 了解更多
  27. Amylin (rat)

    Catalog No. A16892
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    Amylin receptor ligand
    Amylin (rat) is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor. Sequence: Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Disulfide bridge: Cys2-Cys7);KCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTY-NH2 (Disulfide bridge: Cys2-Cys7). 了解更多
  28. ICEC0942 HCl

    Catalog No. A16903
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    CDK7 inhibitor
    ICEC0942, also known as CT7001, is an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. It selectively inhibits CDK7, with an IC50 of 40nM; IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. 了解更多
  29. Vorasidenib

    Catalog No. A16908
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    IDH1 Inhibitor
    Vorasidenib, also known as AG-881, is a potent and selective orally available inhibitor of mutated forms of both isocitrate dehydrogenase type 1 (IDH1, IDH1 [NADP+] soluble) in the cytoplasm and type 2 (IDH2, isocitrate dehydrogenase [NADP+], mitochondrial) in the mitochondria, with potential antineoplastic activity. 了解更多
  30. ABX-464

    Catalog No. A16912
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    HIV replication inhibitor
    ABX-464, also known as SPL-464, is an inhibitor of the HIV replication potentially for the treatment of HIV infection. 了解更多
  31. 3-methoxy Tyramine HCl

    Catalog No. A16917
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    3-methoxy Tyramine (HCl) is a natural metabolite of dopamine, produced by catechol-O-methyltransferase (COMT). 了解更多
  32. AZD1208 HCl

    Catalog No. A16927
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    PIM kinases inhibitor
    AZD1208 hydrochloride is a novel, orally bioavailable, highly selective PIM kinases inhibitor. 了解更多
  33. Coelenterazine H

    Catalog No. A16939
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    Coelenterazine h is a derivative of Coelenterazine. Coelenterazine h is more sensitive to Ca2+ than is the native complex, thus providing a valuable tool for measuring small changes in Ca2+ concentrations. 了解更多
  34. BPTU

    Catalog No. A16952
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    P2Y1 antagonist
    BPTU is a P2Y1 antagonist. It has been shown to provide antithrombotic efficacy and reduce bleeding liability. 了解更多
  35. BAY-678

    Catalog No. A16866
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    HNE inhibitor
    BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). 了解更多
  36. LY2452473

    Catalog No. A16873
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    androgen receptor modulator (SARM)
    LY2452473 is an orally bioavailable selective androgen receptor modulator (SARM), with potential tissue-selective androgenic/anti-androgenic activity. 了解更多
  37. GSK-7975A

    Catalog No. A16931
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    CRAC channel inhibitor
    GSK-7975A is a potent and orally available CRAC channel inhibitor. 了解更多
  38. 3AC

    Catalog No. A12817
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    SHIP1 Inhibitor
    3AC is a cell-permeable, selective inhibitor of SHIP1 polyphosphatase activity toward PIP3 (IC50 = 10 μM), but has no effect on SHIP2 or PTEN activity on PIP3. 了解更多
  39. LDS 751

    Catalog No. A16941
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    Dye Reagents
    LDS 751 is a cell-permeable fluorescent nucleic acid dye that can be used to label double-stranded DNA (dsDNA) within live or dead cells. 了解更多
  40. Glecaprevir

    Catalog No. A16948
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    HCV NS3/4A protease inhibitor
    Glecaprevir, also known as ABT-493 and A-1282576, is a novel HCV NS3/4A protease inhibitor, with IC50 values ranging from 3.5 to 11.3 nM. 了解更多
  41. Rogaratinib

    Catalog No. A16963
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    FGFR inhibitor
    Rogaratinib, also known as BAY-1163877, is an aberrant fibroblast growth factor receptor (FGFR) inhibitor. 了解更多
  42. MRX-2843

    Catalog No. A16958
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    MERTK and FLT3 inhibitor
    MRX-2843 is an orally available small-molecule inhibitor of both MERTK and FLT3. 了解更多
  43. COTI-2

    Catalog No. A16974
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    COTI-2 is an orally available thiosemicarbazone that activates mutant forms of p53. It induces apoptosis in a wide variety of human tumor cells in culture, inhibits the proliferation of colorectal cancer cell lines, and is active against human glioblastoma cell lines at nanomolar concentrations. 了解更多
  44. Fucoxanthin

    Catalog No. A16976
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    Fucoxanthin is a carotenoid that occurs naturally in certain algae. It significantly reduces abdominal white adipose tissue (WAT) in mice and rats when included in their diet. 了解更多
  45. 2-D08

    Catalog No. A16852
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    SUMO inhibitor
    2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays. 了解更多
  46. PLX8394

    Catalog No. A16840
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    BRAF inhibitor
    PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity. 了解更多
  47. MK-8353 (SCH900353)

    Catalog No. A16838
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    ERK inhibitor
    MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay). 了解更多
  48. PK11007

    Catalog No. A16833
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    p53 activator
    PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR. 了解更多
  49. ABBV-744

    Catalog No. A16831
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    BET bromodomain inhibitor
    ABBV-744 is a BDII-selective BET bromodomain inhibitor that is being investigated to treat AML and metastic castration-resistant prostate cancer. 了解更多

产品 1 到 50 共 1148个

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