“bcl”的搜索结果

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  1. Bcl-2 Inhibitor

    Catalog No. A13580
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    Bcl-2 抑制剂
    Bcl-2 Inhibitor包含两种互变异构体的混合物。一种有效的,细胞可渗透的Bcl-2抑制剂与Bak BH3肽竞争体外结合Bcl-2和Bcl-XL的作用(分别为IC50 = 10 uM和7 uM)。 了解更多
  2. Gambogic acid

    Catalog No. A11988
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    Bcl-2 抑制剂
    Gambogic acid是从藤黄汉树中分离出的天然产物。藤黄酸激活半胱氨酸蛋白酶,EC50为0.78-1.64μM,并竞争性抑制Bcl-XL,Bcl-2,Bcl-W,Bcl-B,Bfl-1和Mcl-1,IC50为1.47、1.21、2.02、0.66、1.06和 分别为0.79μM。 了解更多
  3. MCL-1/BCL-2-IN-4

    Catalog No. A18380
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    Mcl-1 and Bcl-2 dual 抑制剂
    MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor. 了解更多
  4. MCL-1/BCL-2-IN-3

    Catalog No. A18385
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    Mcl-1 and Bcl-2 dual 抑制剂
    MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectively. 了解更多
  5. (+)-Apogossypol

    Catalog No. A16316
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    Bcl-2 family 抑制剂
    (+)-Apogossypol是Bcl-2家族蛋白的有效抑制剂。与Bcl-2,Bcl-XL,Mcl-1,Bcl-W和Bcl-B上的BH3肽结合位点竞争,但与Bfl-1竞争,IC50为0.5至2μM。 了解更多
  6. ABT-737

    Catalog No. A10255
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    Bcl-2 抑制剂
    ABT-737是一种类BH3抑制剂,能同时抑制Bcl-xL,Bcl-2和Bcl-w,EC50分别为78.7 nM,30.3 nM和197.8 nM;但对Mcl-1,Bcl-B及Bfl-1没有抑制作用。 了解更多
  7. Sabutoclax

    Catalog No. A12823
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    Bcl-2 抑制剂
    Sabutoclax (BI-97C1)是pan-Bcl-2抑制剂,包括Bcl-xL,Bcl-2,Mcl-1和Bfl-1,IC50分别为0.31 μM,0.32 μM,0.20 μM和0.62 μM。 了解更多
  8. ABT-263 (Navitoclax)

    Catalog No. A10022
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    Bcl-2 抑制剂
    ABT-263 (Navitoclax)是一种有效的Bcl-2家族抑制剂 (Bcl-2,Bcl-xL和Bcl-w的Ki <1 nmol/L)。ABT-263对Bcl- xL,Bcl-2和Bcl-w,( Ki≤1nmol/ L) 维持高亲和力,但与Mcl-1和A1的结合更弱。 了解更多
  9. Bcl 6 Human

    Catalog No. AP1901
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    Bcl-6 Protein Human Recombinant 了解更多
  10. BM-1074

    Catalog No. A12743
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    Bcl-2/Bcl-xL 抑制剂
    BM-1074是有效且有效的Bcl-2/Bcl-xL抑制剂,Ki <1 nM。 了解更多
  11. BM 957

    Catalog No. A18387
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    Bcl-2 and Bcl-xL 抑制剂
    BM 957 is a potent Bcl-2 and Bcl-xL inhibitor, with Kis of 1.2, <1 nM and IC50s of 5.4, 6.0 nM respectively. 了解更多
  12. Bcl XL Human, His

    Catalog No. AP2056
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    B-Cell Lymphoma Extra Large Human Recombinant, His Tag 了解更多
  13. Bcl XL Human, GST

    Catalog No. AP2055
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    B-Cell Lymphoma Extra Large Human Recombinant, GST 了解更多
  14. Bcl XL Human

    Catalog No. AP2054
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    B-Cell Lymphoma Extra Large Human Recombinant 了解更多
  15. Bcl 2 Human (minus NWGR domain)

    Catalog No. AP2049
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    B-Cell Leukemia/Lymphoma 2 Human Recombinant (?CNWGR) 了解更多
  16. Bcl 2 Human (minus BH3 domain)

    Catalog No. AP2048
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    B-Cell Leukemia/Lymphoma 2 Human Recombinant (?CBH3) 了解更多
  17. Bcl 2 Human (minus BH2 domain)

    Catalog No. AP2047
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    B-Cell Leukemia/Lymphoma 2 Human Recombinant (?CBH2) 了解更多
  18. Bcl 2 Human (minus BH1 domain)

    Catalog No. AP2046
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    B-Cell Leukemia/Lymphoma 2 Human Recombinant (?CBH1) 了解更多
  19. Bcl 2 Human (1-206 a.a.)

    Catalog No. AP2045
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    B-Cell Leukemia/Lymphoma 2, (1-206 a.a.) Human Recombinant 了解更多
  20. Bcl 2 Human (minus BH4 domain)

    Catalog No. AP1863
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    B-Cell Leukemia/Lymphoma 2 Human Recombinant (-BH4) 了解更多
  21. Bcl XL Mouse

    Catalog No. AP0569
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    B-Cell Leukemia/Lymphoma XL Mouse Recombinant 了解更多
  22. AT-101

    Catalog No. A15004
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    Bcl-2 抑制剂
    (R)-(-)-Gossypol对映体AT101与Bcl-2,Bcl-xL和Mcl-1结合,Ki分别为0.32μM,0.48μM和0.18μM。 了解更多
  23. AT101 acetic acid

    Catalog No. A13578
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    pan Bcl-2 抑制剂
    AT101 acetic acid对映体AT101与Bcl-2,Bcl-xL和Mcl-1结合,Ki分别为0.32μM,0.48μM和0.18μM;不抑制BIR3域和BID。 了解更多
  24. ABT-199 (Venetoclax)

    Catalog No. A12500
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    Bcl-2 抑制剂
    ABT-199 (Venetoclax) 是一种所谓的BH3类似药物,旨在阻断Bcl 2蛋白的功能。 了解更多
  25. AZD-4320

    Catalog No. A17171
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    Bcl-2/Bcl-XL 抑制剂
    AZD-4320是BH3模拟物和双重Bcl-2/Bcl-XL抑制剂。AZD4320 对于 KPUM-MS3,KPUM-UH1,和 STR-428 细胞系的 IC50 分别为 26 nM,17 nM,和 170 nM。 了解更多
  26. (S)-Gossypol acetic acid

    Catalog No. A16323
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    (S)-Gossypol acetic acid是Bcl-2的抑制剂,在过表达Bcl-2(IC50,18.1μM)或Bcl-xL(IC50,22.9μM)的Jurkat细胞中有效诱导细胞死亡。 了解更多
  27. Apogossypolone (ApoG2)

    Catalog No. A16314
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    Bcl-2 抑制剂
    Apogossypolone (ApoG2)是一种Bcl-2的非肽小分子抑制剂。 了解更多
  28. A-1331852

    Catalog No. A16190
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    BCL-XL 抑制剂
    A-1331852是有效的选择性BCL-XL抑制剂。BCL-XL是主要的抗凋亡生存蛋白,可能是CML中的新型治疗靶标。 了解更多
  29. TW-37

    Catalog No. A10955
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    Bcl-2 抑制剂
    TW-37是Bcl-2的小分子抑制剂,可抑制胰腺癌细胞的生长,并通过一种涉及Notch-1和Jagged-1失活的新途径介导的胰腺癌细胞凋亡。 了解更多
  30. DT2216

    Catalog No. A22050
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    BCL-XL degrader
    DT2216 is a potent and selective BCL-XL degrader based on PROTAC technology. 了解更多
  31. S55746 hydrochloride

    Catalog No. A21811
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    BCL-2 inhibitor
    S55746 hydrochloride (BLC201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. 了解更多
  32. PROTAC Bcl2 degrader-1

    Catalog No. A18355
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    degrader
    PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. 了解更多
  33. S55746

    Catalog No. A18361
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    BCL-2 抑制剂
    S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity. 了解更多
  34. Dihydrokaempferol

    Catalog No. A18383
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    antiarthritic drugs
    Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs. 了解更多
  35. WEHI-539 hydrochloride

    Catalog No. A13327
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    Bcl-xL 抑制剂
    WEHI-539 hydrochloride是BCL-xL的小分子抑制剂,IC50值为1.1 nM。 了解更多
  36. A-1155463

    Catalog No. A16112
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    BCL-XL 抑制剂
    A-1155463是一种高效且选择性强的BCL-XL抑制剂,A-1155463显示与BCL-XL的皮摩尔结合亲和力(Ki = <0.01 nM),与BCL-2的结合力弱1000倍以上(Ki = 80 nM) 和相关蛋白BCL-W(Ki = 19 nM)和MCL-1(Ki> 440 nM)。 了解更多
  37. BH3I-1

    Catalog No. A16061
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    Bcl-XL 拮抗剂
    BH3I-1是Bcl-XL-BH3 domain interaction抑制剂,Ki值为2.4 μM。它是一种Bcl-2家族蛋白的选择性抑制剂。 了解更多
  38. BDA-366

    Catalog No. A15821
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    Bcl-2 拮抗剂
    BDA-366选择性抑制BCL2,将其转化为细胞死亡诱导剂。 了解更多
  39. Acetate gossypol

    Catalog No. A14795
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    Bcl-2 抑制剂
    Acetate gossypol是一种从棉籽中分离出来的多酚化合物,可通过模仿BH3来抑制Bcl-2。 了解更多
  40. HA14-1

    Catalog No. A11448
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    Bcl-2 抑制剂
    HA14-1与Bcl-2相互作用,抑制Bcl-2的抗凋亡作用。 了解更多
  41. Obatoclax mesylate (GX15-070)

    Catalog No. A10665
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    Bcl-2 抑制剂
    Obatoclax Mesylate (GX15-070)是一种Bcl-2拮抗剂,拮抗所有抗凋亡Bcl-2家族蛋白(平均IC50,3 umol/L),包括Mcl-1(IC50,2.9 umol/L)和Bfl-1(IC50,5 umol/L)。 了解更多
  42. 5,?7,?4'-?Trimethoxyflavone

    Catalog No. A22408
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    anticancer agent
    5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner. 了解更多
  43. Asperosaponin VI

    Catalog No. A14474
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    osteoblast differentiation inducer
    Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP?\2/p38 and ERK1/2 pathway. Asperosaponin ?? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB. 了解更多
  44. Guggulsterone

    Catalog No. A19825
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    Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. 了解更多
  45. Clofilium tosylate

    Catalog No. A12267
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    Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent. 了解更多
  46. Thevetiaflavone

    Catalog No. A18365
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    Thevetiaflavone could upregulate the expression of Bcl?2 and downregulate that of Bax and caspase?3. 了解更多
  47. Mcl1-IN-11

    Catalog No. A18377
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    Mcl-1 inhibitor
    Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively. 了解更多
  48. Mcl1-IN-12

    Catalog No. A18379
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    Mcl-1 inhibitor
    Mcl1-IN-12 (Compound F) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively. Anti-tumor activity. 了解更多
  49. Destruxin B

    Catalog No. A18384
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    insecticidal and anticancer
    Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. 了解更多
  50. A-385358

    Catalog No. A17064
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    Bcl-XL 抑制剂
    A-385358是Bcl-XL的抑制剂,可增强多种肿瘤细胞系中多种化学治疗剂(紫杉醇,依托泊苷,顺铂和阿霉素)的体外细胞毒活性。 了解更多

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