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￥ 0.00 “jwh 018”的搜索结果
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NS-018 maleate
Catalog No. A16226 JAK2 抑制剂NS-018 maleate是在Ba/F3-JAK2V617F细胞中具有ATP竞争性的JAK2小分子抑制剂，IC50为470nM。与其他JAK家族激酶（例如JAK1，JAK3和酪氨酸激酶2）相比，对JAK2的选择性高30-50倍。 了解更多 -
NS-018 hydrochloride
Catalog No. A16225 -
NS-018
Catalog No. A16224 -
H-β-Ala-AMC TFA
Catalog No. A22059 -
BAY 2416964
Catalog No. A22067 aryl hydrocarbon receptor (AHR) antagonistBAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment. 了解更多 -
Amarogentin
Catalog No. A22286 bitter taste receptor TAS2R1 agonistAmarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. 了解更多 -
Nicotinamide riboside chloride
Catalog No. A22018 Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride is used in dietary supplements. 了解更多 -
GSK2018682
Catalog No. A20752 S1P1/S1P5 receptor agonistGSK2018682 is an agonist for S1P1 and S1P5 receptor with pEC50s of 7.7 and 7.2, respectively, and has no agonist activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used in the research of multiple sclerosis. 了解更多 -
Mal-amido-PEG8-C2-acid
Catalog No. A20548 nonclaevable ADC linkerMal-amido-PEG8-C2-acid (example 142) is a nonclaevable ADC linker, extracted from patent US2018339985. 了解更多 -
Antimicrobial Compound 1
Catalog No. A20189 Antimicrobial Compound 1 is an alkylpyridinium compound, with antimicrobial activity. 了解更多 -
Oral antiplatelet agent 1
Catalog No. A20188 Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro as well as antithrombotic efficacy in a rat model. P2Y receptor antagonist. 了解更多 -
Irindalone
Catalog No. A20187 -
Sulfaproxiline
Catalog No. A20186 Sulfaproxiline is a synthetic antimicrobial drug that is sulfonamide. 了解更多 -
Thalidomide-O-amido-C4-NH2
Catalog No. A20184 E3 ligase ligand-linker conjugateThalidomide-O-amido-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多 -
DC1SMe
Catalog No. A20181 DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. 了解更多 -
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Catalog No. A20180 E3 ligase ligand-linker conjugate(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. 了解更多 -
Pparδ agonist
Catalog No. A20088 PPARδ agonistPPARδ agonist is a PPARδ agonist extracted from patent US20180071304, compound example 10. 了解更多 -
ROCK2-IN-2
Catalog No. A20062 ROCK2 inhibitorROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM. 了解更多 -
sPLA2-X Inhibitor 31
Catalog No. A20018 sPLA2-X inhibitorsPLA2-X Inhibitor 31 is a selective secreted phospholipase A2 type X (sPLA2-X) inhibitor with IC50s of 26 nM, 310 nM, and 2230 nM for sPLA2-X, sPLA2-IIa, and sPLA2-V, respectively. 了解更多 -
GLP-1 receptor agonist 1
Catalog No. A19885 GLP-1 receptor agonistGLP-1 receptor agonist 1 is a glucagon-like peptide-1 (GLP-1) receptor agonist extracted from patent WO2018056453A1, Compound 67. 了解更多 -
CDK12-IN-3
Catalog No. A19768 CDK12 inhibitorCDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC50 of 491 nM in enzymatic assay. 了解更多 -
Kv3 modulator 1
Catalog No. A19338 Kv3 voltage-gated potassium channel modulatorKv3 modulator 1 is a Kv3 voltage-gated potassium channel modulator extracted from patent WO2018020263A1, Compound X. Kv3 modulator 1 can be used to treat inflammatory pain. 了解更多 -
YF-2
Catalog No. A21018 histone acetyltransferase activatorYF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease. 了解更多 -
2-Keto Crizotinib
Catalog No. A21848 2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib. 了解更多 -
CP-640186 hydrochloride
Catalog No. A21808 ACC inhibitorCP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. 了解更多 -
Encequidar mesylate
Catalog No. A21556 P-glycoprotein inhibitorEncequidar mesylate (HM30181 mesylate; HM30181A mesylate) is a competitive and potent P-glycoprotein inhibitor. 了解更多 -
(S)-(-)-5-Fluorowillardiine
Catalog No. A21337 -
Encequidar
Catalog No. A21212 P-glycoprotein inhibitorEncequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein. 了解更多 -
Relebactam
Catalog No. A21071 diazabicyclooctane inhibitorRelebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. 了解更多 -
GSK2110183 analog 1
Catalog No. A21053 GSK2110183 analog 1 is the structural analogue of GSK2110183. 了解更多 -
Niraparib hydrochloride
Catalog No. A18018 PARP1 and PARP2 inhibitorNiraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. 了解更多 -
KRas G12C inhibitor 4
Catalog No. A12972 KRas G12C inhibitorKRas G12C inhibitor 1 is a compound that inhibits KRas G12C, extracted from patent US 20180072723 A1. 了解更多 -
Ruxolitinib sulfate
Catalog No. A11467 JAK1/2 inhibitorRuxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3. 了解更多
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