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搜索结果：“jwh 250”

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NU 1025

Catalog No. A15375
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PARP 抑制剂

NU 1025是一种有效的聚（ADP-核糖）聚合酶（PARP）抑制剂，可增强L1210细胞中一系列机制多样的抗癌药的细胞毒性。了解更多

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BMN-673 8R,9S

Catalog No. A15024
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PARP 抑制剂

BMN-673 8R,9S 是BMN-673的（8R，9S）对映异构体。BMN 673是一种新型PARP抑制剂，IC50为0.58 nM。了解更多

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BMN673

Catalog No. A11243
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PARP 抑制剂

BMN-673是核酶聚（ADP-核糖）聚合酶（PARP）的口服生物利用抑制剂，无细胞试验中对PARP1的IC50为0.57 nM。它也是有效的PARP-2抑制剂，但不抑制PARG，对PTEN突变型高度敏感。具有潜在的抗肿瘤活性。了解更多

Product Citations (2)

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- Subhajit Chatterjee, .et al. Combination of talazoparib and olaparib enhanced the curcumin-mediated apoptosis in oral cancer cells by PARP-1 trapping, J Cancer Res Clin Oncol, 2022, Dec;148(12):3521-3535 PMID: 35962813
- Charles-André Philip, .et al. Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors, BMC Cancer, 2017, 17: 638 PMID: 28886696

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