你的浏览器似乎禁用了 JavaScript。
您必须在浏览器中启用JavaScript才能使用本网站的功能。

微信关注
申请试用装

主页 /
搜索结果：“jwh 370”

“jwh 370”的搜索结果

Quick View
BTZ043 (BTZ038, BTZ044) Racemate

Catalog No. A10165
Quick View

添加到收藏
DprE1 抑制剂

BTZ043 (BTZ038,BTZ044) Racemate 抑制癸二烯基磷酸基-β-d-核糖2α-表异构酶，它是一种产生致病细菌结核分枝杆菌细胞壁的酶。了解更多

Bulk Inquiry
Quick View
Pimecrolimus

Catalog No. A10732
Quick View

添加到收藏
Pimecrolimus是一种天然的子囊霉素大内酰胺，可与大亲霉素12（FKBP-12）结合并抑制钙调神经磷酸酶和脯氨酰异构酶（旋转异构酶）。了解更多

Bulk Inquiry
Quick View
Tubacin

Catalog No. A10954
添加到收藏
HDAC6 抑制剂

Tubacin (tubulin acetylation inducer)是一种高效且选择性强，可逆，可透过细胞的HDAC6抑制剂，IC50为4 nM。了解更多

Bulk Inquiry
Quick View
KRN 633

Catalog No. A10504
Quick View

添加到收藏
VEGFR 抑制剂

KRN 633是一种细胞可渗透、可逆、ATP竞争性VEGFR激酶抑制剂，仅在较高浓度下(IC50 = 0.97 μM和4.33 μM)抑制PDGFR-α和C-Kit，对其他17种激酶无活性(IC50 ≥ 10 μM)。了解更多

Bulk Inquiry Free Sample
Quick View
MK-2461

Catalog No. A11753
Quick View

添加到收藏
c-Met 抑制剂

MK-2461是一种新型的多靶点激酶抑制剂，优先抑制活化的c-Met受体。了解更多

Bulk Inquiry
Quick View
OC 000459

Catalog No. A11946
Quick View

添加到收藏
CRTH2 拮抗剂

OC 000459是一种有效的口服和选择性CRTH2（也称为DP2）拮抗剂。了解更多

Bulk Inquiry
Quick View
P505-15 (PRT062607, BIIB057)

Catalog No. A11952
Quick View

添加到收藏
Syk 抑制剂

P505-15 (PRT062607,BIIB057)是一种新型的，高度选择性的，Syk抑制剂（SYK IC（50）= 1 nM），具有比SYK活性至少高80倍的抗SYK活性。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
Quick View
ANX-510

Catalog No. A12370
添加到收藏
ANX-510是基于叶酸的生物调节剂，具有潜在的抗肿瘤活性。5,10-亚甲基四氢叶酸（MTHF）稳定氟尿嘧啶代谢物5-5-氟-2'-脱氧尿苷-5'-O-单磷酸酯（FdUMP）与目标酶胸苷酸合酶的共价结合，从而抑制胸苷酸合酶，三磷酸胸苷的消耗（TTP），DNA的必要成分以及肿瘤细胞死亡。与亚叶酸钙不同，作为叶酸的活性形式的MTHF不需要代谢活化，并且可以提高氟尿嘧啶的化学治疗效果，且毒性较低。了解更多

Product Citations (1)

Bulk Inquiry
- Chern Chiuh Woo, .et al. Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma, Oncotarget, 2016, Aug 16; 7(33): 53005-53017 PMID: 27391339
Quick View
JNK-IN-8

Catalog No. A12749
Quick View

添加到收藏
JNK 抑制剂

JNK-IN-8是第一种JNK1，JNK2和JNK4不可逆JNK抑制剂，IC50分别为4.7 nM，18.7 nM和1 nM。了解更多

Product Citations (1)

Bulk Inquiry
- Mark P Roberto, .et al. Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis, Immunity, 2021, Aug 10;54(8):1807-1824.e14 PMID: 34380064
Quick View
Cangrelor (AR-C69931)

Catalog No. A12843
Quick View

添加到收藏
Cangrelor (AR-C69931)是一种有效的静脉内二磷酸腺苷受体拮抗剂。了解更多

Product Citations (1)

Bulk Inquiry Free Sample
- Satoru Koyanagi, .et al. Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia, Nat Commun, 2016, 7: 13102 PMID: 27739425
Quick View
BCH

Catalog No. A13370
添加到收藏
LAT1 抑制剂

BCH是L型氨基酸转运蛋白LAT1的抑制剂。通过激活KB，Saos2和C6癌细胞系中的半胱氨酸蛋白酶抑制生长并诱导凋亡。了解更多

Bulk Inquiry
Quick View
Cilliobrevin D

Catalog No. A12913
Quick View

添加到收藏
cytoplasmic dynein 拮抗剂

Ciliobrevin D是第一个特定的细胞质动力蛋白小分子拮抗剂。了解更多

Bulk Inquiry
Quick View
Batimastat (BB-94)

Catalog No. A12985
Quick View

添加到收藏
MMP 抑制剂

Batimastat (BB-94)是多种基质金属蛋白酶（MMP）的强效合成抑制剂，包括间质胶原酶（IC50 = 3 nM），溶血素（IC50 = 20 nM），Mr 72,000型IV胶原酶（IC50 = 4） nM），92,000型IV胶原酶先生（IC50 = 4 nM）和基质溶素（IC50 = 6 nM）。它是一种低分子量（MW = 478）的肽样胶原蛋白底物类似物，由类似物结合而成，分别与MMP和催化活性锌原子结合在一起。了解更多

Bulk Inquiry Free Sample
Quick View
TP-434 (Eravacycline)

Catalog No. A13887
Quick View

添加到收藏
TP-434 (Eravacycline)是一种新型的广谱氟环素抗生素，对表达主要抗生素抗性机制（包括四环素特异性外排和核糖体保护）的细菌具有活性。了解更多

Product Citations (3)

Bulk Inquiry Free Sample
- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Fan Zhang, .et al. Eravacycline activity against clinical S. aureus isolates from China: in vitro activity, MLST profiles and heteroresistance, BMC Microbiol, 2018, 18: 211 PMID: 30545293
- Jin-xin Zheng, .et al. Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae, Emerg Microbes Infect, 2018, 7: 139 PMID: 30068997
Quick View
PRT062607 HCL

Catalog No. A12731
Quick View

添加到收藏
Syk 抑制剂

PRT2607，也称为PRT062607，P505-15和BIIB057，是一种新型，高度选择性且口服可生物利用的小分子SYK抑制剂（SYK IC（50）= 1 nM），具有至少80倍的抗SYK活性大于对其他激酶的亲和力。了解更多

Bulk Inquiry Free Sample
Quick View
UNC1215

Catalog No. A12948
Quick View

添加到收藏
L3MBTL3 抑制剂

UNC1215是具有细胞活性的L3MBTL3的强效选择性拮抗剂。了解更多

Bulk Inquiry
Quick View
Atovaquone

Catalog No. A13708
Quick View

添加到收藏
Atovaquone是一种抗原生动物线粒体电子传递抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
Mevastatin

Catalog No. A13709
Quick View

添加到收藏
HMG-CoA reductase 抑制剂

Mevastatin是HMG-CoA还原酶的抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
ESI-09

Catalog No. A14233
Quick View

添加到收藏
EPAC1/EPAC2 抑制剂

ESI-09是一种直接由cAMP（EPAC）抑制剂激活的特异性交换蛋白，对于EPAC1和EPAC2，IC50为3.2 uM和1.4 uM。了解更多

Bulk Inquiry
Quick View
1-Azakenpaullone

Catalog No. A14303
Quick View

添加到收藏
GSK-3β 抑制剂

1-Azakenpaullone是一种有效的选择性GSK-3β抑制剂，IC50为18 nM，选择性比CDK1/cyclin B和CDK5/p25高100倍。了解更多

Bulk Inquiry
Quick View
DTP348

Catalog No. A14410
Quick View

添加到收藏
CAIX 抑制剂/ radiosensitizer

DTP348是双重CAIX抑制剂/放射增敏剂。了解更多

Bulk Inquiry
Quick View
CAY10650

Catalog No. A14355
Quick View

添加到收藏
cPLA2α 抑制剂

CAY10650是一种高效（IC50 = 12 nM）cPLA2α抑制剂。了解更多

Bulk Inquiry
Quick View
AK-1

Catalog No. A14370
Quick View

添加到收藏
SIRT2 抑制剂

AK-1比SIRT1和SIRT3选择性抑制SIRT2。了解更多

Bulk Inquiry
Quick View
RG108

Catalog No. A13054
Quick View

添加到收藏
DNA methyltransferase 抑制剂

RG108是DNA甲基转移酶的非核苷抑制剂，IC50为115 nM。了解更多

Bulk Inquiry
Quick View
Cyclothiazide

Catalog No. A13700
Quick View

添加到收藏
AMPA desensitization 抑制剂

Cyclothiazide是苯并噻二叠氮，可作为AMPA受体的增效剂，正向调节其对谷氨酸的响应（EC50 = 3.8 M）。了解更多

Bulk Inquiry
Quick View
NBMPR

Catalog No. A13701
Quick View

添加到收藏
ENT1 抑制剂

NBMPR是一种核苷类似物，可竞争性抑制平衡的核苷转运蛋白1（大鼠和人的Kd = 0.1-1.0 nM，IC50s = 4.6和3.6 nM）。了解更多

Bulk Inquiry
Quick View
Zerumbone

Catalog No. A13703
Quick View

添加到收藏
Zerumbone是一种天然单环倍半萜烯，首先从野生姜Z. zerumbet的根茎中分离出来。1它通过佛波酯（IC50 = 140 nM）有效抑制爱泼斯坦-巴尔病毒的激活。了解更多

Bulk Inquiry
Quick View
25-hydroxy Cholesterol

Catalog No. A13704
Quick View

添加到收藏
25-hydroxy Cholesterol是一种衍生自膳食胆固醇的侧链取代氧固醇，可抑制固醇调节元件结合蛋白（SREBPs）的裂解，从而抑制各种细胞类型中的内源性胆固醇合成。了解更多

Bulk Inquiry
Quick View
Bromocriptin mesylate

Catalog No. A13705
Quick View

添加到收藏
dopamine D2 receptor 激动剂

Bromocriptin mesylate是一种有效的多巴胺受体激动剂，它以最高的亲和力（Ki = 2.5 nM）与D2受体结合。了解更多

Bulk Inquiry Free Sample
Quick View
O6-Benzylguanine

Catalog No. A13706
Quick View

添加到收藏
MGMT 抑制剂

O6-Benzylguanine是DNA烷基转移酶的有效底物和有效灭活剂。O6-苄基鸟嘌呤是MGMT的抑制剂。了解更多

Bulk Inquiry Free Sample
Quick View
K-252a

Catalog No. A14001
Quick View

添加到收藏
K-252a是最初从诺卡氏菌属（Nocardiopsis sp.）的培养液中分离的代谢产物。实验表明，在高浓度下，该化合物是ATP竞争性环核苷酸依赖性蛋白激酶的抑制剂。了解更多

Bulk Inquiry
Quick View
Genkwanin

Catalog No. A14787
Quick View

添加到收藏
Genkwanin是源自沉香叶片的抗肿瘤成分。了解更多

Bulk Inquiry Free Sample
Quick View
L-Stepholidine

Catalog No. A15145
Quick View

添加到收藏
L-Stepholidine是天然存在于草药Stephania intermedia中的化合物。L-Stepholidine是双重D2受体拮抗剂和D1受体激动剂。了解更多

Bulk Inquiry
Quick View
SCH 563705

Catalog No. A15234
Quick View

添加到收藏
CXCR2/CXCR1 拮抗剂

SCH 563705是有效的双重CXCR2（IC50 = 1.3 nM)/CXCR1（IC50 = 7.3 nM）拮抗剂。了解更多

Bulk Inquiry
Quick View
UK 370106

Catalog No. A15316
Quick View

添加到收藏
MMP-3/MMP-12 Inhiibitor

UK 370106是一种高度选择性的MMP-3和MMP-12抑制剂。了解更多

Bulk Inquiry
Quick View
TC-H 106

Catalog No. A15357
Quick View

添加到收藏
HDAC 抑制剂

TC-H 106是一种慢速，紧密结合的I类HDAC（组蛋白脱乙酰基酶）抑制剂。了解更多

Bulk Inquiry
Quick View
4-HQN

Catalog No. A15370
Quick View

添加到收藏
PARP 抑制剂

4-HQN已显示抑制PARP（聚（ADP-核糖）合成酶），该酶催化NAD+的ADP-核糖部分与各种蛋白质的共价结合。了解更多

Bulk Inquiry
Quick View
GSK2879552

Catalog No. A15547
Quick View

添加到收藏
LSD1 抑制剂

GSK2879552是一种可逆的赖氨酸特异性脱甲基酶1（LSD1）抑制剂，具有潜在的抗肿瘤活性。了解更多

Bulk Inquiry
Quick View
E7820

Catalog No. A15456
Quick View

添加到收藏
lpha-2-integrin 抑制剂

E7820是一种小分子芳香族磺酰胺衍生物，具有潜在的抗血管生成和抗肿瘤活性。E7820通过抑制整合素α2（一种在内皮细胞上表达的细胞粘附分子）来抑制血管生成。了解更多

Bulk Inquiry
Quick View
AZ-33

Catalog No. A13341
Quick View

添加到收藏
LDHA 抑制剂

AZ33是LDHA抑制剂。了解更多

Bulk Inquiry
Quick View
PF-3274167

Catalog No. A13754
Quick View

添加到收藏
Oxytocin 拮抗剂

PF-3274167是一种高亲和力非肽催产素受体（OTR）拮抗剂，Ki为9.5 nM。了解更多

Bulk Inquiry
Quick View
CID 797718

Catalog No. A13809
Quick View

添加到收藏
PKD1 抑制剂

CID797718是CID755673（Adooq目录号A13804）的结构类似物。它是效力降低10倍的PKD1抑制剂，IC50值为7.0+/-0.8 uM。了解更多

Bulk Inquiry
Quick View
CL-387785 (EKI-785)

Catalog No. A13146
Quick View

添加到收藏
EGFR 抑制剂

CL-387785是EGFR的不可逆抑制剂，IC50为370+/-120 pM；能够在功能水平上克服由T790M突变引起的抗药性。了解更多

Bulk Inquiry
Quick View
BML-210

Catalog No. A15935
Quick View

添加到收藏
HDAC 抑制剂?

BML-210是HDAC抑制剂。BML-210诱导宫颈癌细胞中的生长抑制和凋亡并调节HDAC和DAPC复合物的表达水平。了解更多

Bulk Inquiry Free Sample
Quick View
Naloxegol Oxalate

Catalog No. A15972
Quick View

添加到收藏
Opioid 拮抗剂

Naloxegol Oxalate是用于治疗阿片类药物引起的便秘的外周选择性阿片类药物拮抗剂。了解更多

Bulk Inquiry
Quick View
FLT3-IN-1

Catalog No. A16249
Quick View

添加到收藏
FLT3 抑制剂

FLT3-IN-1是一种新型的有效选择性Flt3抑制剂，IC50为10 nM。抗表达FLT3-ITD的MV4-11细胞，IC50为6 nM。了解更多

Bulk Inquiry
Quick View
CI 976

Catalog No. A16370
Quick View

添加到收藏
ACAT/SOAT 抑制剂

CI 976是肝和肠酰基辅酶A胆固醇酰基转移酶（ACAT）和固醇O-酰基转移酶（SOAT）的三甲氧基脂肪酸苯胺抑制剂。Cl 976降低非高密度脂蛋白（non-HDL）胆固醇并增加HDL-胆固醇浓度。了解更多

Bulk Inquiry
Quick View
Azlocillin sodium salt

Catalog No. A16422
Quick View

添加到收藏
Azlocillin sodium salt是一种具有广泛抗细菌作用的氨苄青霉素。了解更多

Bulk Inquiry
Quick View
BRD2 Human

Catalog No. AP1370
Quick View

添加到收藏
Bromodomain Containing 2 Human Recombinant 了解更多

Bulk Inquiry
Quick View
CAPS Human

Catalog No. AP0370
Quick View

添加到收藏
Calcyphosine Human Recombinant 了解更多

Bulk Inquiry

联系我们

Not your Region? View all Distributors

ADOOQ 产品质量保证

Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.