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3-Methyltoxoflavin
Catalog No. A19466 PDI inhibitor3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM. 了解更多 -
Inarigivir
Catalog No. A19351 Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. 了解更多 -
ONO-8590580
Catalog No. A19337 -
TRPM8 antagonist 2
Catalog No. A19329 TRPM8 antagonistTRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. 了解更多 -
CU-CPT-8m
Catalog No. A19309 -
Medronic acid
Catalog No. A19250 Medronic acid (Methylenediphosphonic acid) is a methylene-substituted bisphosphonate. Medronic acid accumulates at sites of osteoid mineralization and can be used, complexed with radioisotopes in bone imaging. 了解更多 -
KAN0438757
Catalog No. A19216 PFKFB3 inhibitorKAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM . 了解更多 -
Cariprazine
Catalog No. A21202 D3 receptor and D2 receptor partial agonistCariprazine is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). 了解更多 -
Arginase inhibitor 1
Catalog No. A21007 arginases I and II inhibitorArginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. 了解更多 -
all-trans-4-Oxoretinoic acid
Catalog No. A21978 all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs). 了解更多 -
Ralimetinib
Catalog No. A21942 p38 MAPK α/β inhibitorRalimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. 了解更多 -
AZD5153 6-Hydroxy-2-naphthoic acid
Catalog No. A21852 BET/BRD4 bromodomain inhibitorAZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM. 了解更多 -
GSK2194069
Catalog No. A21827 hFAS inhibitorGSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ?? 4.1 nM in an assay detecting released CoA. 了解更多 -
BCI hydrochloride
Catalog No. A21797 dual specificity phosphatase inhibitorBCI hydrochloride ((E)-BCI hydrochloride) is an allosteric inhibitor of dual specificity phosphatase (DUSP). 了解更多 -
Rusalatide acetate
Catalog No. A21791 regenerative peptideRusalatide acetate (TP508 amide acetate), a regenerative peptide, mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity. 了解更多 -
Kira8 Hydrochloride
Catalog No. A21780 IRE1α inhibitorKira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. 了解更多 -
Nazartinib mesylate
Catalog No. A21741 covalent mutant-selective EGFR inhibitorNazartinib mesylate (EGF816 mesylate) is a novel, covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min?1 on EGFR(L858R/790M) mutant, respectively. 了解更多 -
GSK2807 Trifluoroacetate
Catalog No. A21731 SMYD3 inhibitorGSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM. 了解更多 -
Taranabant ((1R,2R)stereoisomer)
Catalog No. A21705 CB1 receptor inverse agonistTaranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist. 了解更多 -
(1R,2R)-2-PCCA(hydrochloride)
Catalog No. A21655 GPR88 receptor agonist(1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay. 了解更多 -
Pradefovir mesylate
Catalog No. A21644 Pradefovir mesylate is a good substrate for liver CYP3A4. Pradefovir is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with a Km of 60 μM. 了解更多 -
(R)-BAY1238097
Catalog No. A21593 BET binding to histones inhibitor(R)-BAY1238097 is the R-isomer with lower activity of BAY1238097. BAY1238097 is a potent and selective inhibitor of BET binding to histones and has strong anti-proliferative activity in different AML (acute myeloid leukemia) and MM (multiple myeloma) models through down-regulation of c-Myc levels and its downstream transcriptome. 了解更多 -
IACS-8968 S-enantiomer
Catalog No. A21559 dual IDO/TDO inhibitorIACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多 -
IACS-8968 R-enantiomer
Catalog No. A21555 dual IDO/TDO inhibitorIACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多 -
Deruxtecan
Catalog No. A21522 Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. 了解更多 -
Prinomastat
Catalog No. A21501 metalloproteinase inhibitorPrinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. 了解更多 -
Macozinone
Catalog No. A21488 DprE inhibitorMacozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2??-oxidase) inhibitor. 了解更多 -
LYN-1604 hydrochloride
Catalog No. A21449 ULK1 activatorLYN-1604 hydrochloride is a potent ULK1 activator with an EC50 of 18.94 nM. 了解更多 -
42-(2-Tetrazolyl)rapamycin
Catalog No. A21394 mTOR inhibitor42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor. 了解更多 -
(R)-Nedisertib
Catalog No. A21375 (R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK. 了解更多 -
Tonapofylline
Catalog No. A21328 adenosine A1 receptor antagonistTonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure. 了解更多 -
Pavinetant
Catalog No. A21174 NK3R antagonistPavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist. 了解更多 -
B-Raf IN 1
Catalog No. A21055 B-Raf kinase inhibitorB-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM. 了解更多 -
RS102895 hydrochloride
Catalog No. A20918 CCR2 antagonistRS102895 hydrochloride is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1. 了解更多
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