“jwh 250”的搜索结果

产品 201 到 250 共 1231个

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  1. GNE-049

    Catalog No. A20206
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    CBP inhibitor
    GNE-049 is a highly potent and selective CBP inhibitor with an IC50 of 1.1 nM in TR-FRET assay. GNE-049 also inhibits BRET and BRD4(1) with IC50s of 12 nM and 4200 nM, respectively. 了解更多
  2. Homogentisic acid

    Catalog No. A12940
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    Homogentisic acid is a specific metabolite in urine and serum, which is used for diagnosis of alkaptonuria. 了解更多
  3. CPA inhibitor

    Catalog No. A11369
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    CPA inhibitor
    CPA inhibitor is a potent inhibitor for carboxypeptidase A (CPA). 了解更多
  4. HLY78

    Catalog No. A18402
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    Wnt/β-catenin 激活剂
    HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. 了解更多
  5. ORM-10103

    Catalog No. A18404
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    Na+/Ca2+ exchanger (NCX) 抑制剂
    ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively. 了解更多
  6. Pseudouridimycin

    Catalog No. A18520
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    RNA polymerase 抑制剂
    Pseudouridimycin (PUM), an antibiotic, is a selective bacterial RNA polymerase (RNAP) inhibitor. Pseudouridimycin is a C-nucleoside analogue that is effective against both Gram-negative and Gram-positive bacteria. 了解更多
  7. IAXO-102

    Catalog No. A18543
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    TLR4 antagonist
    IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. 了解更多
  8. Taurodeoxycholate sodium salt

    Catalog No. A18577
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    Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholate (TDCA) inhibits various inflammatory responses. 了解更多
  9. TD-106

    Catalog No. A18595
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    CRBN modulator
    TD-106 is a cereblon (CRBN) modulator, which can be used for targeted protein degradation. BRD4 PROTACs with TD-106 induce BRD4 degradation. 了解更多
  10. Zylofuramine

    Catalog No. A18604
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    Zylofuramine is a psychomotor stimulant. 了解更多
  11. PF-06250112

    Catalog No. A18612
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    BTK 抑制剂
    PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively. 了解更多
  12. 5'-Deoxyadenosine

    Catalog No. A18618
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    5'-deoxyadenosine, also known as 5'dAdo or 5'-dAdo, is a substrate of bacterial methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase and a product inhibitor produced by radical SAM enzymes. 了解更多
  13. Ureidopropionic acid

    Catalog No. A18625
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    Ureidopropionic acid is an intermediate in the metabolism of uracil. 了解更多
  14. BPN14770

    Catalog No. A18663
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    PDE4D inhibitor
    BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. 了解更多
  15. AKOS B018304

    Catalog No. A18719
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    AKOS B018304 is an arylalkylidene derivative, with polar substitution at para-position. 了解更多
  16. BMS-986165

    Catalog No. A18726
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    TYK2 抑制剂
    BMS-986165 is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. 了解更多
  17. NCT-502

    Catalog No. A18751
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    PHGDH inhibitor
    NCT-502 is an inhibitor of human 3-phosphoglycerate dehydrogenase (PHGDH). 了解更多
  18. DSP-0565

    Catalog No. A18753
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    DSP-0565 is a strong, broad-spectrum anti-epileptic drug (AED) candidate with unique GABAergic function. 了解更多
  19. (-)-(S)-B-973B

    Catalog No. A18761
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    α7 nAChR modulator
    -)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity. 了解更多
  20. Bromperidol

    Catalog No. A18254
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    Bromperidol, also known as Impromen and R-11333, is used as a means of long-term maintenance treatment of schizophrenia. Bromperidol is a close structural analogue of haloperidol. C3435T polymorphism is associated with some therapeutic response to bromperidol in schizophrenic patients, possibly by different drug concentration in the brain. 了解更多
  21. Taltirelin

    Catalog No. A18250
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    TRH-R agonist
    Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release). 了解更多
  22. Epristeride

    Catalog No. A18231
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    5 alpha-reductase inhibitor
    Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. 了解更多
  23. Nifurtimox

    Catalog No. A18227
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    Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH). 了解更多
  24. Icatibant

    Catalog No. A18074
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    Bradykinin B2 receptors antagonist
    Icatibant (HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. 了解更多
  25. Bendazac L-lysine

    Catalog No. A17975
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    Bendazac L-Lysine is one of agents that have been introduced for the management of cataracts, protecting the level of vision in patients, thus delaying the need for surgical intervention. 了解更多
  26. Fondaparinux Sodium

    Catalog No. A17918
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    factor Xa inhibitor
    Fondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII). 了解更多
  27. Iodixanol

    Catalog No. A17560
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    Iodixanol is a contrast agent. It is commonly used as a contrast agent during coronary angiography. It is the only iso-osmolar contrast agent, with an osmolality of 290 mOsm/kg H2O??the same as blood. 了解更多
  28. Revaprazan Hydrochloride

    Catalog No. A17506
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    Acid pump antagonist
    Revaprazan hydrochloride is a novel acid pump antagonist (APA). Revaprazan hydrochloride reduces COX-2 expression and has significant anti-inflammatory actions activities in H. pylori infection. 了解更多
  29. SSE15206

    Catalog No. A18350
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    Microtubule/Tubulin Inhibitor
    SSE15206 is a pyrazolinethioamide derivative that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. 了解更多
  30. Destruxin B

    Catalog No. A18384
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    insecticidal and anticancer
    Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. 了解更多
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    MRTX1257

    Catalog No. A17223
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    KRAS-G12C inhibitor
    MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM. 了解更多
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    AZ304

    Catalog No. A17225
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    dual BRAF 抑制剂
    AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively. 了解更多
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    Fevipiprant

    Catalog No. A17244
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    CRTh2 receptor antagonist
    Fevipiprant, also known as NVP-QAW039 or QAW039, is an oral active and potent CRTh2 receptor antagonist and potentially useful for asthma treatment. 了解更多
  31. JNJ-38877618

    Catalog No. A18325
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    c-Met inhibitor
    JNJ-38877618 is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. 了解更多
  32. Porcn-IN-1

    Catalog No. A18330
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    Potent porcupine inhibitor
    Porcn-IN-1 is potent porcupine inhibitor with an IC50 of 0.5??0.2 nM. 了解更多
  33. Trapidil

    Catalog No. A17409
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    Trapidil is a vasodilator, is an antiplatelet drug with specific platelet-derived growth factor. 了解更多
  34. Procyclidine HCl

    Catalog No. A17371
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    Muscarinic antagonist
    Procyclidine hydrochloride is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in Parkinsonism. 了解更多
  35. Piromidic Acid

    Catalog No. A17370
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    Piromidic acid is antibacterial against mainly gram negative organisms. It is used for urinary tract and intestinal infections. 了解更多
  36. Tasimelteon

    Catalog No. A17351
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    MT1 and MT2 receptor agonist
    Tasimelteon is a melatonin MT1 and MT2 receptor agonist. 了解更多
  37. Cinchonine (LA40221)

    Catalog No. A17250
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    Cinchonine prevents High-Fat-Diet-Induced Obesity through downregulation of Adipogenesis and Adipose inflammation. 了解更多
  38. GIBH-130

    Catalog No. A18333
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    Neuroinflammation inhibitor
    GIBH-130 is an effective inhibitor of neuroinflammation. GIBH-130 significantly suppresses the IL-1β secretion by activated microglia (IC50=3.4 nM). 了解更多
  39. GSK 2250665A

    Catalog No. A17191
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    Itk 抑制剂
    GSK-2250665A是pKi = 9.2的Itk抑制剂,它对Aurora B激酶和Btk(pIC50值分别为6.4和6.5)和一组其他激酶表现出对Itk的选择性。 抑制PBMC中IFNγ的产生。 了解更多
  40. AF 12198

    Catalog No. A17213
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    IL-1 receptor 拮抗剂
    AF 12198是人I型白介素1(IL-1)受体的有效选择性拮抗剂。 了解更多
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    TR-14035

    Catalog No. A17118
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    Integrin 拮抗剂
    TR-14035是α4β7和α4β1整联蛋白的双重拮抗剂。 了解更多
  41. 1M7

    Catalog No. A17133
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    RNA reagent
    1M7是RNA试剂。 了解更多
  42. GSK4112

    Catalog No. A17135
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    Rev-Erbα 激动剂
    GSK4112是选择性的Rev-erbα激动剂,EC50值为250 nM。GSK4112是小分子化学探针, 用于核血红素受体REV-erbα的细胞生物学研究。 了解更多
  43. E6446 HCl

    Catalog No. A17149
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    E6446 HCl是核酸敏感TLR的合成拮抗剂。 了解更多
  44. PF-06737007

    Catalog No. A17179
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    Trk 抑制剂
    PF-06737007是泛原肌球蛋白相关激酶(Trk)抑制剂。 了解更多
  45. AMG-333

    Catalog No. A17182
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    TRPM8 拮抗剂
    AMG-333是有效的选择性TRPM8拮抗剂,IC50为13 nM。 了解更多
  46. Antineoplaston A10

    Catalog No. A17183
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    Ras 抑制剂
    Antineoplaston A 10是Ras抑制剂,可能用于治疗神经胶质瘤,淋巴瘤,星形细胞瘤和乳腺癌。 了解更多

产品 201 到 250 共 1231个

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页面:
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  2. 4
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