CDK

FILTER BY:

购物选项

作用机制
  1. Inhibitor (抑制剂) (96)
  2. Agonist (激动剂) (1)
  3. Degrader (降解剂) (1)
靶点
  1. Aurora A (1)
  2. Aurora B (1)
  3. CDK (3)
  4. CDK4 (2)
  5. FLT3 (3)
  6. JAK2 (2)
Catalog No.Inhibitor Name CDK1CDK2CDK3CDK4CDK5CDK6CDK7CDK8CDK9CLKCDKCdcOther
A10701Palbociclib HCl
****
***
A10806Roscovitine
*
**
*
ERK2,GST-ERK1,ERK1
A10850SNS-032
*
***
*
*
**
****
GSK-3α,GSK-3β
A11129Dinaciclib
****
****
****
****
A10390Flavopiridol
***
***
***
**
*
A10093AT7519
**
**
**
***
**
*
****
GSK-3β
A11045Flavopiridol HCl
***
***
*
***
***
*
A10494JNJ-7706621
****
****
*
**
Aurora A,Aurora B,VEGFR2
A11105AZD5438
***
****
**
***
A11167MK-8776
**
Chk1,Chk2
A10716PHA-793887
**
****
**
****
****
**
GSK-3β
A10163BS-181 HCl
***
A13811Palbociclib Isethionate
****
***
A11034A-674563
**
Akt1,PKA,GSK-3β
A16386abemaciclib
****
****
A11154BMS-265246
****
****
**
A11164PHA-767491
**
**
*
***
****
****
GSK-3β,MK2,PLK1
A11047Milciclib
*
***
**
*
**
TrkA
A11190R547
****
****
****
GSK-3β
A14136NU6027
*
*
ATR,DNA-PK
A13547P276-00
**
**
**
*
*
***
GSK-3β,PKCα,c-Src
A11220Kenpaullone
*
*
*
GSK-3β,ERK2,c-Src
A15889K03861
****
A14192THZ1
****
A11313AT7519 HCl
**
**
*
**
***
**
*
****
GSK-3β
A15517Purvalanol A
***
*
****
A14437Ro-3306
***
PKCδ,SGK,ERK
A14318SU9516
***
***
**
PDGFR
A13677XL413
****
****
Pim1,CK2
A14273LDC000067
*
*
*
***
A14297ML167
**
A13721TG003
***
A13549Ribociclib
A12216Wogonin
A10471Indirubin
*
GSK-3β
A11347CGP60474
***
***
PKCα
A12352Purvalanol B
****
****
A12438NU 6102
***
****
*
A12989LY2835219 (abemaciclib)
****
***
A14025AMG-925
*
****
FLT3
A15054CVT 313
*
*
*
A15196NVP-LCQ195
****
***
****
CHK2
A15767NU2058
*
*
DNA topoisomerase II ATPase
A15823LY2857785
*
***
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 97个

每页
页面:
  1. 1
  2. 2

设置降序顺序
  1. ON123300

    Catalog No. A12584
    Quick View
    CDK4 抑制剂?
    ON123300是一种有效的多激酶抑制剂,对CDK4, Ark5, PDGFRβ, FGFR1, RET, Fyn的IC50分别为3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM和11nM,可能对脑肿瘤化学治疗有用。ON123300强烈抑制Ark5和CDK4,以及生长因子受体酪氨酸激酶,如β-型血小板衍生的生长因子受体(PDGFRβ)。 了解更多
  2. RGB-286638

    Catalog No. A13130
    Quick View
    CDK 抑制剂
    RGB-286638是一种新型CDK抑制剂,对于细胞周期蛋白T1-CDK9/细胞周期蛋白B1-CDK1/细胞周期蛋白E-CDK2/细胞周期蛋白D1-CDK4/细胞周期蛋白E-CDK3的IC50为1 nM/2 nM/3 nM/4 nM/5 nM/p35-CDK5分别;对细胞周期蛋白H-CDK7和细胞周期蛋白D3-CDK6的效力较低。 了解更多
  3. LY2857785

    Catalog No. A15823
    Quick View
    CDK9 抑制剂
    LY2857785是一种有效的选择性CDK9抑制剂。显着降低RNA聚合酶II CTD的磷酸化并显着降低MCL1蛋白水平,从而导致多种白血病和实体瘤细胞系发生凋亡。 了解更多
  4. SY-1365

    Catalog No. A18482
    Quick View
    CDK7 inhibitor
    SY-1365 is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors. 了解更多
  5. NG52

    Catalog No. A12494
    Quick View
    Cell cycle-regulating kinase 抑制剂
    NG52 (Compound 52)是细胞周期调节激酶Cdc28p(IC50 = 7 μM)和相关Pho85p激酶(IC50 = 2 μM)的有效,可渗透细胞,可逆,选择性和ATP兼容的抑制剂。 了解更多
  6. THAL-SNS-032

    Catalog No. A19088
    Quick View
    CDK9 degrader PROTAC
    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多
  7. AT7519 trifluoroacetate

    Catalog No. A15005
    Quick View
    CDK 抑制剂
    AT7519 trifluoroacetate是CDK1、2、4、6和9的多CDK抑制剂,IC50为10-210 nM,对CDK3的效力较低,对CDK7的活性较低。 了解更多
  8. FMF-04-159-2

    Catalog No. A18911
    Quick View
    CDK14 inhibitor
    FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. 了解更多
  9. CDK2-IN-4

    Catalog No. A18667
    Quick View
    CDK2 inhibitor
    CDK2-IN-4 is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM). 了解更多
  10. Abemaciclib Metabolites M2

    Catalog No. A18416
    Quick View
    CDK4/CDK6 inhibitor
    Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s in the range of 1-3 nM. Anti-cancer activity. 了解更多
  11. CDK9 inhibitor 2

    Catalog No. A15039
    CDK9 抑制剂
    CDK9 inhibitor 2 是一种新型的细胞周期蛋白依赖性激酶9(CDK9)抑制剂。 了解更多
  12. NSC 663284

    Catalog No. A13524
    Quick View
    Cdc25 抑制剂
    NSC 663284是所有Cdc25同工型的有效,细胞可渗透且不可逆的抑制剂,首选Cdc25A(对于Cdc25A,Cdc25B2和Cdc25C,IC50分别为29、95和89 nM)。 了解更多
  13. AZD5597

    Catalog No. A13506
    Quick View
    CDK 抑制剂
    AZD5597是有效的CDK抑制剂,对一系列癌细胞具有体外抗增殖作用。 了解更多
  14. MSC2530818

    Catalog No. A12644
    Quick View
    CDK8 inhibitor
    MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8. 了解更多
  15. PHA690509

    Catalog No. A13550
    Quick View
    CDK 抑制剂
    PHA690509是ATP竞争性CDK抑制剂。 了解更多
  16. Ro 3306

    Catalog No. A14437
    Quick View
    CDK1 抑制剂
    Ro 3306是一种具有ATP竞争能力的有效细胞周期蛋白依赖性激酶(cdk)1抑制剂(cdk1/cyclin B1和cdk1/cyclin A的Ki值分别为35和110 nM。 了解更多
  17. FN-1501

    Catalog No. A13559
    Quick View
    FLT3/CDK inhibitor
    FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity. 了解更多
  18. CA-224

    Catalog No. A14414
    Quick View
    CDK4 抑制剂
    CA-224是有效的CDK4抑制剂,也是fascaplysin的非平面类似物,在体外特异性抑制Cdk4-cyclin D1。 了解更多
  19. CDK4/6-IN-2

    Catalog No. A18657
    Quick View
    CDK4/CDK6 inhibitor
    CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor with IC50s of 2.7 and 16 nM for CDK4 and CDK6, respectively. 了解更多
  20. BI-1347

    Catalog No. A18769
    Quick View
    CDK8 inhibitor
    BI-1347 is a selective inhibitor of CDK8/cyclin C with an IC50 of 1.1 nM. 了解更多
  21. MC180295

    Catalog No. A18892
    Quick View
    CDK9 inhibitor
    MC180295 is a highly selective CDK9 inhibitor (IC50 = 5 nM). MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect. 了解更多
  22. Lerociclib (G1T38)

    Catalog No. A18320
    Quick View
    CDK inhibitor
    Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 1 nM, 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively. 了解更多
  23. AZD4573

    Catalog No. A18321
    Quick View
    CDK9 inhibitor
    AZD4573 is a potent and selective inhibitor of CDK9, with fast-off binding kinetics and high selectivity versus other kinases, including other CDK family kinases. 了解更多
  24. NVP-2

    Catalog No. A17022
    Quick View
    CDK9 抑制剂
    NVP-2是一种有效的选择性ATP竞争性CDK9抑制剂,IC50值为0.5 nM。 了解更多
  25. BAY-1251152

    Catalog No. A17029
    Quick View
    CDK9 抑制剂
    BAY-1251152,也称为(+)-BAY-1251152,是CDK9抑制剂。 了解更多
  26. THZ531

    Catalog No. A17036
    Quick View
    CDK12 and CDK13 covalent 抑制剂
    THZ531是CDK12和CDK13共价抑制剂。THZ531不可逆地靶向位于激酶结构域外部的半胱氨酸。THZ531导致基因表达缺失,同时延伸和过度磷酸化RNA聚合酶II缺失。 了解更多
  27. Trilaciclib

    Catalog No. A17084
    Quick View
    CDK4/6 抑制剂
    Trilaciclib是潜在的一流的短效CDK4/6抑制剂,正在开发中,可在化学疗法中保存造血干细胞并增强免疫系统功能。 了解更多
  28. SEL120-34A

    Catalog No. A17086
    Quick View
    CDK8 抑制剂
    SEL120-34A是一种有效且选择性的CDK8抑制剂,在AML细胞中具有高水平的STAT1和STAT5反式激活域丝氨酸磷酸化活性。 了解更多
  29. PF-06873600

    Catalog No. A16875
    Quick View
    CDK 抑制剂
    PF-06873600是一种口服生物利用型,细胞周期蛋白依赖性激酶(CDK)抑制剂,其对 CDK2、CDK4和CDK6的Ki值分别为 0.09 nM、0.13 nM 和 0.16 nM。具有潜在的抗肿瘤活性。 了解更多
  30. ICEC0942 HCl

    Catalog No. A16903
    Quick View
    CDK7 抑制剂
    ICEC0942 HCl,也称为CT7001,是CDK7的口服生物利用选择性抑制剂。它选择性抑制CDK7,IC50为40nM。CDK1,CDK2,CDK5和CDK9的IC50值分别高45倍,15倍,230倍和30倍。 了解更多
  31. Atuveciclib (BAY-1143572)

    Catalog No. A16810
    Quick View
    Selective PTEFb/CDK9 抑制剂
    Atuveciclib (BAY-1143572)是目前处于I期的PTEFb/CDK9的高度选择性,有效且可口服的抑制剂。 了解更多
  32. SB1317 (TG02)

    Catalog No. A13454
    Quick View
    CDK/JAK2/FLT3 抑制剂
    SB1317是细胞周期蛋白依赖性激酶(CDKs)、类FMS酪氨酸激酶-3(FLT3)和Janus激酶2(JAK2)的有效抑制剂,CDK2、JAK2和FLT3的IC50值分别为13nM、56nM和73nM。 了解更多
  33. LY2835219 methanesulfonate

    Catalog No. A16386
    Quick View
    CDK4/6 抑制剂
    LY2835219是一种有效且选择性的CDK4和CDK6抑制剂,在无细胞试验中的IC50分别为2 nM和10 nM。 了解更多
  34. LY-3177833

    Catalog No. A16325
    Quick View
    CDC7 抑制剂
    LY-3177833是CDC7(细胞分裂循环7相关蛋白激酶)的有效和选择性抑制剂。 了解更多
  35. Bohemine

    Catalog No. A15942
    Quick View
    CDK 抑制剂
    Bohemine是一种有效且选择性的,细胞可渗透的,细胞周期蛋白依赖性激酶(CDK)抑制剂,IC50 = 1,M。 了解更多
  36. K03861

    Catalog No. A15889
    Quick View
    CDK 抑制剂
    K03861是II型CDK2抑制剂,其CDK2(WT),CDK2(C118L),CDK2(A144C)和CDK2(C118L/A144C)的Kd分别为50 nM,18.6 nM,15.4 nM和9.7 nM。 了解更多
  37. bio-THZ1

    Catalog No. A18559
    Quick View
    covalent CDK7 inhibitor
    bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. 了解更多
  38. Flavopiridol HCl

    Catalog No. A11045
    Quick View
    CDK 抑制剂
    Flavopiridol HCl是细胞周期蛋白依赖性激酶的抑制剂。(-)-顺式形式诱导特定肿瘤细胞的凋亡。 了解更多
  39. JNJ-7706621

    Catalog No. A10494
    Quick View
    CDK/Aurora A/B 抑制剂
    JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂,IC50为9 nM/4 nM,并且在无细胞分析中对CDK1/2的选择性是CDK3/4/6的6倍以上。它还能有效抑制极光A/B,对Plk1和Wee1没有活性。 了解更多
  40. PHA-848125 (Milciclib)

    Catalog No. A11047
    CDK 抑制剂
    PHA-848125 (Milciclib)是一种有效的,ATP竞争性CDK抑制剂,作用于CDK2,IC50为45 nM,作用于CDK2比作用于CDK1,2,4,5和7选择性高3倍以上。 了解更多
  41. AZD5438

    Catalog No. A11105
    Quick View
    CDK 抑制剂
    AZD5438是有效的细胞周期蛋白依赖性激酶(CDK)1、2和9抑制剂(IC50值分别为16、6和20 nM)。 了解更多
  42. BMS-265246

    Catalog No. A11154
    Quick View
    CDK 抑制剂
    BMS-265246是cdk2/cyclin E和cdk1/cyclin B以及cdk4/cyclin D的强新吡唑并吡啶抑制剂。 了解更多
  43. BS-181

    Catalog No. A10163
    Quick View
    CDK 抑制剂
    BS-181 是作为CDK7抑制剂的潜在抗肿瘤剂。 了解更多
  44. AT7519

    Catalog No. A10093
    Quick View
    CDK 抑制剂
    AT7519是多种细胞周期蛋白依赖性激酶(CDK)的抑制剂,可导致细胞周期停滞,诱导细胞凋亡和抑制肿瘤细胞增殖。作用于CDK1,2,4,6和9时,IC50为10-210 nM,对CDK3作用效果稍弱,对CDK7几乎没有抑制活性。 了解更多
  45. R547

    Catalog No. A11190
    Quick View
    CDK 抑制剂
    R547是一种新型的细胞周期和转录周期依赖性激酶(CDKs)选择性抑制剂(CDK1,CDK2和CDK4分别为Ki = 1、3和1 nM),具有出色的体外细胞效价,可抑制各种细胞的生长。人肿瘤细胞系。 了解更多
  46. SNS-032 (BMS-387032)

    Catalog No. A10850
    Quick View
    CDK 抑制剂
    SNS-032(BMS-387032)是细胞周期蛋白依赖性激酶(Cdks)2、7和9的高度选择性和有效抑制剂,具有体外生长抑制作用,并具有诱导恶性B细胞凋亡的能力。 了解更多
  47. AT7519 HCl

    Catalog No. A11313
    Quick View
    CDK 抑制剂
    AT7519是多种细胞周期蛋白依赖性激酶(CDK)的抑制剂,可导致细胞周期停滞,诱导细胞凋亡和抑制肿瘤细胞增殖。 了解更多
  48. CGP60474

    Catalog No. A11347
    Quick View
    CDK 抑制剂
    CGP60474是细胞周期蛋白依赖性激酶(CDK)的有效抑制剂。 了解更多
  49. Purvalanol B

    Catalog No. A12352
    Quick View
    CDK 抑制剂
    Purvalanol B是一种细胞周期蛋白依赖性激酶抑制剂。对于cdc2/cyclin B,cdk2/cyclin A,cdk2/cyclin E,cdk4/cyclin D1和cdk5-p35的ic50值分别为6、6、9、> 10,000和6 nm。对一系列其他蛋白激酶具有选择性(IC50 > 10,000 nM)。 了解更多
  50. NU 6102

    Catalog No. A12438
    Quick View
    CDK 抑制剂
    NU 6102与CDK4/D1(IC50 = 1.6μM),DYRK1A(IC50 = 0.9μM),PDK1(IC50 = 0.8μM)和ROCKII(IC50 = 0.6μM)相比,NU6102对CDK1和CDK2具有选择性。 了解更多

产品 1 到 50 共 97个

每页
页面:
  1. 1
  2. 2

设置降序顺序
Rewards