CSF-1R

Catalog No.Inhibitor Name CSF-1ROther
A10025Linifanib
***
VEGFR1/FLT1,FLT3,VEGFR2/KDR
A10679OSI-930
**
FLT1,KDR,LCK
A11959GW2580
*
A13772CEP-32496
***
c-Kit,RET,PDGFRβ
A15520Pexidartinib
**
A15540BLZ945
****
A11472Ki 20227
****
VEGFR-2, PDGFRβ, c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. JNJ-28312141

    Catalog No. A12687
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    CSF1R 抑制剂
    JNJ-28312141是一种口服活性CSF1R抑制剂(Colony-stimulating factor-1受体,CRF1R),也是一种FLT3抑制剂。CSF1R在许多肿瘤中表达,是巨噬细胞的生长因子并介导破骨细胞分化。JNJ-28312141代表一种在急性髓样白血病中以及在依赖CSF-1的巨噬细胞和破骨细胞有助于肿瘤生长和骨骼事件的环境中具有潜在治疗活性的新药物。 了解更多
  2. AZD7507

    Catalog No. A16886
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    CSF-1R 抑制剂
    AZD7507是一种有效的选择性CSF-1R抑制剂(32 nM细胞活性),AZD7507被认为是一种很有前途的化合物,因为它保留了AZ683所需的效能和口服药代动力学特性。 了解更多
  3. PLX5622

    Catalog No. A18888
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    CSF1R inhibitor
    PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development. 了解更多
  4. JTE-952

    Catalog No. A18391
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    CSF-1R 抑制剂
    TE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. 了解更多
  5. c-Fms-IN-8

    Catalog No. A18879
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    CSF-1R, c-FMS Type II inhibitor
    c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. 了解更多
  6. Linifanib (ABT-869)

    Catalog No. A10025
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    VEGFR/PDGFR 抑制剂
    Linifanib (ABT-869)是一种结构新颖的有效RTK,VEGF和PDGF抑制剂,对人内皮细胞,PDGFR-β,KDR和CSF-1R的IC50分别为0.2、2、4和7 nM。 了解更多
  7. OSI-930

    Catalog No. A10679
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    c-Kit/VEGFR 抑制剂
    OSI-930是Kit,KDR,Flt,CSF-1R,c-Raf和Lck的有效抑制剂,IC50分别为80 nM,9 nM,8 nM,15 nM,41 nM和22 nM。 了解更多
  8. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR 抑制剂
    Pazopanib (GW-786034)是VEGFR-1,VEGFR-2,VEGFR-3,PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂,可阻止肿瘤生长并抑制血管生成。 了解更多
  9. GW2580

    Catalog No. A11959
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    CSF-1R 抑制剂
    GW2580是cFMS激酶的小分子,ATP竞争性抑制剂。 了解更多
  10. Ki 20227

    Catalog No. A11472
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    M-CSFR, CSF1R 抑制剂
    Ki 20227是c-Fms酪氨酸激酶(M-CSFR,CSF1R)的抑制剂。 了解更多
  11. CEP-32496

    Catalog No. A13772
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    Raf 抑制剂
    CEP-32496是一种口服v-raf鼠肉瘤病毒癌基因同源物B1(B-raf)丝氨酸/苏氨酸蛋白激酶抑制剂,具有潜在的抗肿瘤活性。 了解更多
  12. BLZ945

    Catalog No. A15540
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    CSF1R 抑制剂
    BLZ945是有效的选择性CSF-1R激酶抑制剂。它减弱了TAM的周转率,同时增加了浸润宫颈癌和乳腺癌的CD8+ T细胞的数量。 了解更多
  13. Pexidartinib (PLX3397)

    Catalog No. A15520
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    CSF1/Kit/FLT3 抑制剂
    Pexidartinib (PLX3397)是KIT,CSF1R和FLT3的小分子酪氨酸激酶(RTK)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  14. Edicotinib

    Catalog No. A13008
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    CSF-1 receptor inhibitor
    Edicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease. 了解更多
  15. GENZ-882706

    Catalog No. A12484
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    CSF-1R Inhibitor
    GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1. 了解更多

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