Product Data Sheet
hSMG-1 inhibitor 11j
Catalog No. A24645
hSMG-1 inhibitor 11j is a potent and selective inhibitor of the human kinase hSMG-1, exhibiting an IC50 of 0.11 nM. This compound demonstrates more than 455-fold selectivity for hSMG-1 compared to mTOR, PI3Kα/γ, and CDK1/CDK2, with IC50 values of 50 nM, 92 nM, 60 nM, and 32/7.1 μM, respectively. It is a valuable tool for cancer research, enabling the investigation of pathways associated with DNA damage response and tumorigenesis.
Chemical Information
| Catalog Num | A24645 |
|---|---|
| M. Wt | 566.07 |
| Formula | C27H28ClN7O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1402452-15-6 |
| Synonyms | |
| SMILES | O=S(C1=CC(NC2=NC=CC(C3=CC(C4=CC=C(NC(NC)=O)C=C4)=NC=C3)=N2)=CC=C1Cl)(N(CC)CC)=O |
| Storage |
Biological Activity
| Discription | hSMG-1 inhibitor 11j is a potent and selective inhibitor of the human kinase hSMG-1, exhibiting an IC50 of 0.11 nM. This compound demonstrates more than 455-fold selectivity for hSMG-1 compared to mTOR, PI3Kα/γ, and CDK1/CDK2, with IC50 values of 50 nM, 92 nM, 60 nM, and 32/7.1 μM, respectively. It is a valuable tool for cancer research, enabling the investigation of pathways associated with DNA damage response and tumorigenesis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
