Product Data Sheet
AKT-IN-3
Catalog No. A25882
AKT-IN-3 is a potent and selective AKT inhibitor that primarily targets the Akt signaling pathway, exhibiting IC50 values of 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3, respectively. This compound also demonstrates significant inhibitory activity against other AGC family kinases, including PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 is utilized in cancer research due to its ability to induce apoptosis and inhibit metastasis in cancer cells, making it a valuable tool for exploring therapeutic strategies against malignancies.
Chemical Information
| Catalog Num | A25882 |
|---|---|
| M. Wt | 526.36 |
| Formula | C23H23Cl2F2N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2374740-21-1 |
| Synonyms | |
| SMILES | CNC(C[C@H]1NC[C@@H](NC(C2=CC(C3=C(Cl)C=NN3C)=C(Cl)O2)=O)[C@H](C4=CC(F)=C(F)C=C4)C1)=O |
| Storage |
Biological Activity
| Discription | AKT-IN-3 is a potent and selective AKT inhibitor that primarily targets the Akt signaling pathway, exhibiting IC50 values of 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3, respectively. This compound also demonstrates significant inhibitory activity against other AGC family kinases, including PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 is utilized in cancer research due to its ability to induce apoptosis and inhibit metastasis in cancer cells, making it a valuable tool for exploring therapeutic strategies against malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
