Product Data Sheet
HDAC6-IN-37
Catalog No. A26409
HDAC6-IN-37 is an inhibitor of histone deacetylase 6 (HDAC6) with demonstrated neuroprotective effects. This compound has been shown to restore the morphology of hippocampal neurons and reduce the expression of amyloid-beta (Aβ), Tau, and phosphorylated Tau (p-Tau) proteins in the hippocampus of Alzheimer's disease (AD) model rats. Additionally, HDAC6-IN-37 inhibits the formation of senile plaques and neurofibrillary tangles while regulating oxidative stress and restoring neurotransmitter balance in brain tissue, making it a valuable tool for Alzheimer's disease research and therapeutic exploration.
Chemical Information
| Catalog Num | A26409 |
|---|---|
| M. Wt | 385.87 |
| Formula | C19H16ClN3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2986486-82-0 |
| Synonyms | |
| SMILES | O=C(C1=CN=C(C=C1)CN2C3=CC=CC=C3SC4=C2C=CC=C4)NO.Cl |
| Storage |
Biological Activity
| Discription | HDAC6-IN-37 is an inhibitor of histone deacetylase 6 (HDAC6) with demonstrated neuroprotective effects. This compound has been shown to restore the morphology of hippocampal neurons and reduce the expression of amyloid-beta (Aβ), Tau, and phosphorylated Tau (p-Tau) proteins in the hippocampus of Alzheimer's disease (AD) model rats. Additionally, HDAC6-IN-37 inhibits the formation of senile plaques and neurofibrillary tangles while regulating oxidative stress and restoring neurotransmitter balance in brain tissue, making it a valuable tool for Alzheimer's disease research and therapeutic exploration. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
