Product Data Sheet
WIZ degrader 1
Catalog No. A26633
WIZ Degrader 1 is a selective degrader targeting widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. This compound induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM, providing a valuable tool for research into inherited blood disorders. Its capability to modulate HbF levels highlights its potential applications in therapeutic strategies for conditions such as sickle cell disease and beta-thalassemia.
Chemical Information
| Catalog Num | A26633 |
|---|---|
| M. Wt | 473.56 |
| Formula | C25H33F2N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2839552-68-8 |
| Synonyms | |
| SMILES | FC1(F)CCC(CN2CC[C@@H](CC3=CC4=C(N5CCC(NC5=O)=O)C=NN4C=C3)C[C@@H]2C)CC1 |
| Storage |
Biological Activity
| Discription | WIZ Degrader 1 is a selective degrader targeting widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. This compound induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM, providing a valuable tool for research into inherited blood disorders. Its capability to modulate HbF levels highlights its potential applications in therapeutic strategies for conditions such as sickle cell disease and beta-thalassemia. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
