Product Data Sheet
CSRM617 hydrochloride
Catalog No. A30202
CSRM617 hydrochloride is a selective inhibitor of the transcription factor ONECUT2, serving as a critical regulator of androgen receptor activity. This compound exhibits a binding affinity with a Kd of 7.43 µM, directly targeting the OC2-HOX domain. In biological assays, CSRM617 hydrochloride has been shown to induce apoptosis, characterized by the cleavage of Caspase-3 and PARP. Its efficacy and tolerability have been demonstrated in prostate cancer mouse models, making it a valuable tool for research in cancer biology.
Chemical Information
| Catalog Num | A30202 |
|---|---|
| M. Wt | 291.69 |
| Formula | C10H14ClN3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1353749-74-2 |
| Synonyms | |
| SMILES | O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O.[H]Cl |
| Storage |
Biological Activity
| Discription | CSRM617 hydrochloride is a selective inhibitor of the transcription factor ONECUT2, serving as a critical regulator of androgen receptor activity. This compound exhibits a binding affinity with a Kd of 7.43 µM, directly targeting the OC2-HOX domain. In biological assays, CSRM617 hydrochloride has been shown to induce apoptosis, characterized by the cleavage of Caspase-3 and PARP. Its efficacy and tolerability have been demonstrated in prostate cancer mouse models, making it a valuable tool for research in cancer biology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
